Term
What are some characteristics of an 'ideal' injectable anesthetic?
(there are 6)
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Definition
- rapid onset of recovery
- lack of tissue toxicity
- lack of adverse cardiovascular and resp effects
- rapid metabolism even in animals with deficient liver and kidney function
- provides analgesia
- provides muscle relaxation
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Term
Barbiturates:
list the 4 representative drugs |
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Definition
Thiopental
Methohexital
Pentobarbital
Phenobarbital |
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Term
| all barbiturates are derivatives of what type of acid? |
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Definition
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Term
Ultrashort-acting drug:
name the representative drug |
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Definition
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Term
| methohexitol has what effect? |
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Definition
it has high lipid solubility, target organ is brain, and brain is highly lipid
drug goes from brain to body fat. once gone from brain, anesthesia is over |
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Term
Short-acting drug:
name the representative drug |
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Definition
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Term
| thiopental has what kind of effect? |
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Definition
rapid effect
brief duration of action |
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Term
Intermediate-acting drug
name the representative drug |
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Definition
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Term
| pentobarbital has what kind of effect? |
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Definition
slow to take effect- less solubility
length of anesthesia and recovery prolonged |
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Term
long-acting drugs
name a representative
(used as sedatives/ anticonvulsants, not as anesthetic drugs) |
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Definition
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Term
| phenobarbital has what kind of effect? |
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Definition
long time for effect
lasts much longer |
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Term
| What types of drugs would be used for general anesthesia? |
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Definition
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Term
| what types of drugs would be used for anticonvulsant therapy? |
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Definition
| pentobarbital, phenobarbitol |
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Term
| what type of drug would be used for sedation? |
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Definition
| phenobarbitol- (not often used) |
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Term
| what type of drug would be used for euthanasia? |
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Definition
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Term
| what factors effect uptake and distribution of drugs on the body? |
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Definition
solubility of the drug in fat
dose and rate of administration
plasma protein level
high TP=less for drug to bind to,+high free drug=high potency |
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