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Immunosuppression Drugs
Induction and Maintenance
9
Pharmacology
03/31/2011
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Term
Antithymocyte Globulin
 Definition
Induction Therapy
Rabbit/horse Antibodies to Human T Cells
Prevent Acute Rejection
Term
Muromonab
 Definition
Induction Therapy
Anti-CD3
Term
Daclizumab
 Definition
Induction Therapy
Anti-IL-2R
Term
Cyclosporine
 Definition
Maintenance Therapy
Calcineurin Inhibitor
Prevents IL-2 transcription
Term
Tacrolimus
 Definition
Maintenance Therapy
Calcineurin Inhibitor (100x more potent)
Prevents IL-2 transcription
Term
Sirolimus (Rapamycin)
 Definition
Maintenance Therapy
mTOR Inhibitor
Inhibit Lymphocyte Growth/Metabolism
Term
Everolimus
 Definition
Maintenance Therapy
mTOR Inhibitor
Inhibit Lymphocyte Growth/Metabolism
Term
Mycophenolate Mofetil
 Definition
Cytotoxic Drug
Inhibits IMPD
Blocks de novo Purine Synthesis
Term
Azathioprine
 Definition
Cytotoxic Drug
Metabolites inhibit de novo Purine Synthesis and DNA Synthesis