Term
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Definition
Oral corticosteroid with various uses which primarily reduces circulating lymphocyte levels
cause Cause
GROWTH RETARDATION
CUSHINGS
PEPTIC ULCERS
AVASCULAR NECROSIS
HIRUSITISM |
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Term
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Definition
IV corticosteriod used in the prophylaxis and management of acute rejection in organ transplants
GREATER THAN 75% SAVED IN REJECTION
Primarily reduces circulating lymphocyte levels and cytokine production
hepatic metabolism |
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Term
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Definition
Calcineurin inhibitor via IMMUNOPHYLIN A (inhibits NFAT --> inhibit cytokines--> inhibits lymphocyte)
Prophylaxis organ rejection during induction and maintenance PREVENTATIVE ONLY and treat inflammatory disorders
slow incomplete absorbtion, metabolized via CYP450
NEPHROTOXIC, GINGIVAL HYPERPLASIA, HIRSITUISM |
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Term
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Definition
Calcineurin inhibitor via FKB-12 (inhibits NFAT --> inhibit cytokines--> inhibits lymphocyte)
Prophylaxis organ rejection during induction and maintenance PREVENTATIVE ONLY and treat inflammatory disorders
slow incomplete absorbtion, metabolized via CYP450
NEPHROTOXIC, HYPERGLYCEMIC
1000X stronger than cyclosporin |
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Term
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Definition
Calcineurin inhibitor via FKB-12 (inhibits NFAT-->inhibits IL2/4-->inhibits lymphocytes)
used to treat mild to moderate atopic dermatitis
Not really used systemically for adverse effects |
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Term
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Definition
Inhibits glutamine PRPP amidotransferase in formation of IMP and Purine salvage pathway therefore ANTIMETABOLITE (IMP imposter)
prophylaxis of organ reject during induction and maintainence PREVENTATIVE ONLY
Converted to 6MP in liver by XANTHINE OXIDASE THEREFORE AVOID ALLOPURINOL
only 50% bioavailable
POLYMORPHISM OF TPMT = toxicity
leukopenia, thrombcytopenia |
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Term
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Definition
Inhibits IMP dehydrogenase (stops GMP formation)
used in prophylaxis organ rejection PREVENTATIVE ONLY
converted to acid, 95% bioavailable with ENTEROHEPATIC RECYCLING THEREFORE AVOID CHOLECYSTIRAMINE and MG containing compounds
similar side effects of azothioprine |
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Term
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Definition
FBK-12 binder inhibits mTOR
PREVENTATIVE AGAINST REJECTION ONLY
locks cells in G1 phase; metabolized in liver
HYPERCHOLESTEROLEMIA |
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Term
| Anti-thymocyte immunoglobulin (ATGAM) |
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Definition
polyclonal antibody prepared from hyperimmune serum of a variety of mammals
Can lead to leukopenia and thrombcytopenia and CRS
ATGAM from horses
Both bind to T cell surface proteins and lead to depletion of T and B cells
Good for induction and tx rejection of solid organ transplants (esp. kidney)
NEVER MAINTAINENCE |
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Term
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Definition
Mouse hybridoma produced antibody to T-cell marker
potential severe CYTOKINE RELEASE SYNDROME side effect (tx steroid) and/or CNS problems
Leads to T cell depletion and impaired T-cell receptors
Good for induction and tx rejection of solid organ transplants
NEVER MAINTAINENCE and HIGHER RISK INFECTION |
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Term
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Definition
Mouse/human chimeric protein that binds to the alpha subunit of IL2 thereby preventing T/B differentiation and proliferation
T1/2>Basiliximab
Good for induction and tx rejection of solid organ transplants ESPLUNG
NEVER MAINTAINENCE |
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Term
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Definition
Humanized monoclonal antibody that binds to the alpha subunit of IL2 thereby preventing T/B differentiation
Good for induction and tx rejection of solid organ transplants ESP LUNG
NEVER MAINTAINENCE |
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Term
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Definition
mouse/human chimeric monoclonal AB against both soluble and membrane bound TNFa
this dampens the production of cytokines and other inflammatory factors
used to treat a variety of inflammatory and autoimmune disorders |
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Term
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Definition
Fusion protein of TNFa receptor and IgG1 against both soluble and membrane bound TNFa
this dampens the production of cytokines and other inflammatory factors
used to treat a variety of inflammatory and autoimmune disorders |
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Term
Interferon gamma
Interleukin 2
IL-4 |
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Definition
INFgamma = activates macrophage
IL2 = proliferation of B and T cells
IL4 = secreted Th to prolif B |
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Term
| Rho(D)immunoglobulin Rhogam |
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Definition
Antibody against the Rh(D) antigen on red blood cells derived from human plasma
prevents sensitization of mother to RD antigen |
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Term
| CI inhibitors interactions |
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Definition
increase CYP3A4 inhibition
Antibiotics
antivirals
antifungals
cardiac |
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