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Immunopharmacology
Pharmacology
21
Medical
Professional
10/23/2011

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Cards

Term
which suppresses immune function by cytotoxicity?
Definition
nonspecific agents
cyclophosphamide
Term
how is tolerance developed?
Definition
small quantities of antigen are administered gradually...this increases IgG which neutralizes binding to E
Term
This drug causes hemorrhagic cystitis, alopecia
Definition
cyclophosphamide
Term
this toxic drug causes hepatic dysfunction
Definition
AZT
Term
Corticosteroid function
Definition
proliferation

tissue injury prevention

inhibit Phospholipid A2
Term
mech of action of corticosteroids results in?
Definition
decreased T and B cells, monocytes, eosinophils and basophils.
Term
function of cyclosporine
Definition
proliferation and differentiation synthesis
Term
this is important for preventing transplant rejection
Definition
cyclosporine
Term
this drug binds to cyclophilin and inactivates T cell activation
Definition
cyclosporine
Term
This macrolide ab has same mech of act as cyclosporine
Definition
tacromilus FK 506
Term
Which one is more potent, tacromilus or cyclosporine
Definition
tacromilus
Term
site of action for AZT (anti metabolite)
Definition
proliferation (inhibits DNA synthesis)
Term
this cytotoxic alkylating agent blocks proliferation
Definition
cyclophosphamide
Term
antilymphyocyte Ab's site action
Definition
antigen specificity
proliferation
differentiation and synthesis
Term
This allows very specific delivery of cytotoxic agents
Definition
ricin
Term
Trastuzumab
Definition
eGFR Her 2 down regulation
Term
Rituximab
Definition
non-Hodgkin's lymphoma
Term
This IL activates lymphocytes
Definition
IL-1
Term
T cell growth factor cytokine
Definition
IL-2

renal cell carcinoma
metastatic melanoma
Term
Interferon action
Definition
stimulation of macrophages and T cells to inhibit viral replication
Term
GM-CSF
Definition
faster recovery of bone marrow
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