Term
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Definition
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Term
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Definition
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Term
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Definition
| Bodily Humors-yellow bile |
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Term
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Definition
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Term
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Definition
-innate immunity
-adaptive immunity |
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Term
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Definition
-born with it
-natural-everyone has it
-same in most people
-epithelial barriers
-phagocytes
-natural killer cells
-responds initially to a threat; quickly |
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Term
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Definition
-acquired; have to encounter before becomes adaptive
-B lymphocytes-->antibodies (humoral)
-T lymphocytes-->Effector T cells |
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Term
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Definition
| Extra cellular microbes-->B lymphocytes-->secreted antibodies |
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Term
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Definition
| ability to recognize and respond to many different microbes |
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Term
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Definition
| enhanced responses to recurrent or persistent infections |
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Term
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Definition
| responses to distinct microbes are optimized for defense against these microbes |
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Term
| Cells of Immune System (IS) |
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Definition
-lymphocytes
-Antigen-presenting cells
-Effector Cells
-Lymphoid tissues |
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Term
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Definition
-small lymphocytes
-large lymphocytes |
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Term
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Definition
-8-10 micrometers
-B-cells
-T-lymphocytes |
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Term
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Definition
-bursa of Fabricus
-bone marrow-derived cells
-produce antibodies
-antigen specific
-increase in number-secondary response
-antigen receptors on their surface |
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Term
| T-lymphocytes=thymus (heart) |
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Definition
-regulate to protein antigens ONLY
-increase in numbers
-effector cell for cell mediated immunology (CMI)
-antigen receptors on surface
-secrete cytokines=hormones of IS |
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Term
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Definition
| -natural killer cells (NK cells) |
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Term
| Natural Killer Cells (NK cells) |
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Definition
-non T/non B markers
-part of the innate IS
-eliminate tumor cells/virus infected cells
-antibody-dependent cell cytotoxicity (ADCC) |
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Term
| Antigen-presenting cells-accessory cells |
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Definition
-capture of antigens for display to lymphocytes
-mononuclear cells
-macrophages
-dendritic cells |
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Term
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Definition
-phagocytes in innate immunity
-bone marrow derived
-release cytokine
+monocytes (10-15 micrometers)
+bean-shaped nucleus
-circulating |
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Term
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Definition
-fixed in tissues
+Kupfer cells (liver)
+microglea
+osteoplast |
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Term
| dendritic cells (DC-accessory cells) |
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Definition
-trap antigens send lymphnodes (T/B cells)
-interdigitating dendritic cells (1st line of defense
+respiratory, skin, oral
-follicular DC-germinal centers of lymphoid tissues
+help activate lymphocytes |
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Term
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Definition
| -granulocytes-contain cytoplasmic granules-not accessory cells |
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Term
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Definition
-neutrophils
-eosinophils
-basophils/mast cells |
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Term
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Definition
-polymorphonuclear (PMN)
-phagolytic cell
-multiple lobed nucleus
-predominant cell type in acute inflammation |
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Term
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Definition
-receptor for IgE (allergic rxns)
-allergic rxns/killing helminths (worms) |
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Term
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Definition
-IgE receptors
-mediate immediate hypersensitivity
+anophylactic shock |
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Term
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Definition
-tissues on organs in which lymphocytic cells originate, mature and differentiate
-primary lymphoid tissues
-secondary lymphoid tissues |
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Term
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Definition
-central/generatice tissues
-bone marrow
+hematopoiesis
+B cell maturation occurs/ no T cell
maturation
-thymus-cortex/medulla
+T cell maturation=T cell "education" |
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Term
| Secondary lymphoid tissues |
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Definition
-segregation between B and T cells
-lymph node |
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Term
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Definition
-T and B cells
-FDC
-macrophages
-bean shaped
-lie along lymphatics
-neck, axillae, groin, aorta
-"sample lymph"; looking for protein
antigens
-lymphatic vessels-drain fluid from
tissues
-anything that enters a tissues will go
through a lymph node |
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Term
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Definition
-phagocytic-filter/phagocytize particular
matter
-antigen presenting cells (APC)-present
antigens to B/T cells |
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Term
| Structures of Lymph Nodes |
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Definition
-cortex/germinal centers/follicles-B cells
-Paricortex-next to the cortex; T cells
-medulla-macrophages |
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