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Immunology
Test 2
82
Biology
Undergraduate 4
06/29/2010

Additional Biology Flashcards

 


 

Cards

Term
The type of immunity acquired following the recovery of a communicable disease like measles is
Definition
Natural Active
Term
Immunity gained due to the introduction of the live poliomelitis vaccine is
Definition
Artificial Active
Term
Artificial passive immunity is employed for
Definition
tetanus antitoxin given for a dirty wound, Rh- mother giving birth to a Rh+ baby, exposure to infectious hepatitus
Term
The harmful AB/AG reaction is termed as
Definition
Allergy and Infection
Term
In a suseptible person, anaphylaxis may occur following
Definition
Injection of penicillin, bee sting, injection of an allergen
Term
Terms synonymous with cellular immunity
Definition
Delayed hypersensitivity and tuberculin hypersensitivity
Term
The increase in vascular permeability in man and guinea pigs in cutaneous anaphylactic reactions is mainly due to
Definition
liberation of histamines
Term
What anti-inflammatory cell is most characteristic of lesions produced by ag-ab complement complexes
Definition
polymorphonuclear neutrophils
Term
The organ most easily affected in chronic immune complex diseases both in experimental animals and in man is
Definition
Kidney
Term
MIF refers to
Definition
Migration Inhibitory Factor in Macrophages
Term
The mode of action of antihistamines in relieving symptoms of allergy is by
Definition
blocking histamine binding to cell membrane
Term
Which of the following is not produced by sensitized T(DH) lymphocytes: TF, CF, IL1, or INF-G
Definition
IL1
Term
All RBC and WBC orginate here
Definition
Bone Marrow
Term
Universal Blood donor type is
Definition
O
Term
Measure of strength of interation between Ab and its epitope
Definition
affinity
Term
Most important mediator released by mast cells in immediate hypersensitivity reaction
Definition
histamine
Term
Most important memory cell type in tumor immunity
Definition
CTL
Term
Hemolytic disease of the newborn is primarily caused by this Ab class
Definition
IgG
Term
Ab are found in this specific plasma protein fraction
Definition
Gamma Globulin
Term
Fetus and newborn are best able to synthesize this Ig class
Definition
IgM
Term
Synonym for class when referring to immunoglobulin
Definition
isotype
Term
Ag specificities which are different in different groups of individuals within a species
Definition
allotypes
Term
Peculiar to a single Ab type made in a single individual or a given species to a single determinant
Definition
idiotype
Term
Cytokine most central to development of adaptive immune response
Definition
IL2
Term
Fetal cell layer found at placental interface between fetus and maternal host
Definition
trophoblast
Term
Very high density of microvilli by EM are seen on the surface of this lymphocyte
Definition
B cell
Term
Substance that is not immunogenic but can react with Ab of appropriate sensitivity
Definition
hapten
Term
Lymphokine toxic to tumor cells in immunological surveillance
Definition
TNF
Term
Most predominant type of lymphocyte found in blood
Definition
t cell
Term
Substance (antigen) that causes an allergic response
Definition
allergen
Term
Used to detect presence of nonhemoagglutinating IgG on surface of human RBC
Definition
antihuman IgG
Term
Ab class important in system anaphylaxis
Definition
IgE
Term
A large molecular weight Ag can have many different ___ ___ molecules bound to it.
Definition
Ab-specific
Term
Immunological memory can last ____ years of longer in humans.
Definition
20
Term
Human t-cells form rosettes with uncoated ____ RBC.
Definition
sheep
Term
____ capable of responding to a specific Ag are already present within a lymphoid tissue prior to exposure to the Ag.
Definition
B cells
Term
Rhematoid factor is IgM directed against the Fc of IgG results in __
Definition
autoimmune disease
Term
The Fc of IgG has cytophillic properties and can activate ___
Definition
the complement system
Term
F (ab')2 can be produced from IgG with ___ treatment.
Definition
pepsin
Term
Penicillin is a ____ that can bind to IgE if specific.
Definition
hapten
Term
The ____hypersensitivty skin test peaks in about 48 hours in humans.
Definition
delayed
Term
In the ____ reaction, neutrophils can be found intradermally.
Definition
Arthus
Term
The delayed hypersensitivity skin test is cell mediated by __
Definition
mononuclear cells
Term
Fish produce on the ____ antibody class.
Definition
IgM
Term
The _____ lymphokine, produced by T(DH), is required for the activation of macrophages to kill tumor cells by direct contact
Definition
MAF
Term
__________ both recruit uncommitted T-cells to a specific Ag.
Definition
IL2 and TF lymphokines
Term
______ is a monokine produced by activated macrophages.
Definition

TNF (alpha)

 

(I think this one is alpha!  I will double check it later!)

Term
The IL2 Lymphokine, produced by Th1, activates ___
Definition
cytotoxic t-cells
Term
___ refers to binding strength of a Fab for its specific antigen determinant
Definition
Affinity
Term
The hypervariable regions of V(H) and V(L) are important in ___
Definition
determining specificity of an Ab molecule
Term
RBC contain blood group ___ for the RBC typing needed for transfusion of blood.
Definition
Ag
Term
___ ____ and ___ are all polymorphoneuclear leukocytes and granulocytes
Definition
basophils, eosinophils, and neutraphils
Term
Neutrophils increase during _____, whereas T-cells increase during ___.
Definition
bacterial infections; viral infections
Term
____ and ___ are agranular mononuclear leukocytes.
Definition
Monocytes and T-lymphocytes
Term
NK cells are ___cells and are large granular lympocytes
Definition
null
Term
The ___ __ is an obligatory precursor substance to which the A and B groups are attached in the ABO blood group system.
Definition
H substance
Term
Anti A and Anti B antibodies (ABO system) are mainly ____ antibody.
Definition
IgM
Term
The _____ reaction is an attack on the donor RBC by the recipient antibody.
Definition
transfusion
Term
IgE shows cytophillic affinity for ___.
Definition
mast cells
Term
Histamine is derived by the ____ of histadine and causes the contractions of smooth muscles
Definition
decarboxylation
Term
Secretory IgA is important in ___ ___ immunity.
Definition
passive natural
Term
In the __ __ response, donor T-lymphocytes attack the recipient cells
Definition
Graft vs. Host
Term
Mast cells have a crucial role in allergies caused by ___.
Definition
IgE
Term
Hemolytic disease of a newborn is due to production of maternal IgG specific for _____________
Definition
fetal erythrocyte Rh antigen
Term
In the early stages of inflammatory response, the predominant cell type infiltrating tissues is the ___.
Definition
neutrophil
Term
The tuberculin (TB) skin test is an example of an ___ hypersensitivity skin test.
Definition
delayed
Term
____ rather than ____ is most likely evolved from animals.
Definition
IgM; IgG
Term
The mast cell is non-phagocytic but has Fc receptors for ___.
Definition
IgE
Term
Macrophages found in the liver are called
Definition
Kupffer cells
Term
The intrauterine fetus is actually an __
Definition
allograft
Term
The blocking AB in ______ therapy against atopic allergies is IgG.
Definition
desensitization
Term
____ ____ would involve an RH+ fetus and an RH - maternal host.
Definition
Erythroblastosis Fetalis
Term
In the _____ reaction, you are in Ab excess and IgG is involved
Definition
Arthus
Term
In______, you are in Ag excess and IgG is involved.
Definition
Serum Sickness
Term
_____ affinity IgG is found in a secondary Ab response.
Definition
High
Term
Poison ivy is an example of ____ hypersensitivity.
Definition
delayed
Term
___ receptors on neutrophils and macrophage surface bind Ab-coated bacterium
Definition
Fc
Term
___ are antibody or complement components that bind to pathogens and thereby facilitate and enhance their phagocytosis.
Definition

Opsonins--(IgG and C3b)

 

I think IgG and C3B are the answer?!

Term
Neutraphil or macrophage cell membranes surround bacteria and fuse, creating a membrance bound vessicle or ___.
Definition
phagosome
Term
___ occurs first during phagocytosis with the generation of toxic oxygen metabolites.
Definition
respiratory burst
Term
_____, containing digestive enzymes, fuse second with the intracellular vesicle.
Definition
lysosomes
Term
____ at the site of an infection is initiated by the chemotactic response of phagocytic cells migrating into the tissues.
Definition
Inflammation
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