Term
| What is the major Ig in blood? What else is there to know about it? |
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Definition
-IgG (80%)
-Also the only Ig that can cross the placenta
-The main Ig of secondary B cell response
-Half life of 23 days
-Fixes compliment |
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Term
| IgA types, location, half-life, compliment fixing ability? |
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Definition
-Can be serum IgA, a monomer
-But is much more commonly secretory IgA, dimer containing a J chain and found in tears, saliva, and mucous
-Secretory chain attached in epithelial cell makes it resistant to proteolytic cleavage in mucous
-Low activation of compliment
-Half life of 5.5 days |
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Term
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Definition
-On mature naive B cells
-Function unknown
-Low half life at 2.8 days |
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Term
| IgE, where found, what does it do, and half-life? |
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Definition
-It D and G are all monomers
-Very little in serum. Mostly on surface of mast cells and basophils, bound via an FcE receptor (binds Fc region of IgE)
-Does parasites and allergic/anaphylactic responses (makes sense to be on mast and basophils)
-Half life is only 2 days
-Does not fix compliment |
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Term
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Definition
-Refers to the allelic changes within a species, typically in heavy chain
-Compair to isotype (IgM vs IgG, etc.), and idiotype (antigen specificity) |
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Term
| How do cells interact with free Ig bound to microorganisms? |
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Definition
| -Via Fc domain and Fc receptors |
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Term
| Which Igs activate compliment? |
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Definition
| -IgM strongly, IgG does okay, IgA weakly |
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Term
| IgM; when is it secreted, compliment fixing, agglutination capacity, half-life? |
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Definition
-It often is a pentamer
-It is the first Ig secreted by B cells in primary response
-It is very good at fixing compliment and agglutination
-Half-life is 5 days |
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Term
| Which Ig can cross placenta? |
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Definition
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Term
| What Ig crosses epithelium? |
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Definition
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Term
| Which Igs sensitize mast cells? |
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Definition
| -Mosly IgE, but IgG can weakly |
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Term
| Interacts best with NK cells, best at opsonization, and best at neutralization? |
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Definition
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Term
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Definition
-immunoreceptor tyrosine-based activation
-On inside of cell attached to CD3 (T cell signal transducer) |
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