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Immunology Problem Set 1
Immunology first packet
38
Medical
Professional
03/08/2009

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Term
mechanism of innate immunity
Definition
consitutively active
complement system
physical
low specificity
Term
adaptive immunity
Definition
high specificity
must be activated
Term
response time frame for adpative and innate immunity
Definition
adaptive immunity-slow
innate immunity-quick
Term
cellular effectors in innate immunity
Definition
toll like receptors
macrophages
NK cells
monocytes
neutrophils
Term
cellular effectors of adaptive immunity
Definition
T cells and B cells
follicular dendritic antigen presenting cells
Term
surface receptor molecules for innate and for adaptive
Definition
for innate: TLR
nuclear cell receptor
inflamasome

surface receptor T cell
B cell receptors
MHC I and II
Term
innate protects against
Definition
bacteria fungi
Term
adaptive protects against
Definition
bacteria fungi virus
Term
example of innate immunity
Definition
neutrophil and bateria
Term
example of adaptive immunity
Definition
vaccine
Term
clonal expansion
Definition
a variety of different t cells makes multiplications of itself
Term
primary lymphoid tissues
Definition
thymus and bone marrow
Term
secondary lymph tissues
Definition
lymph nodes
peyer's patches
tonsils
spleen
mucosal
MALT
GALT
Term
CD8 tcells
Definition
effector cells
MHC I
cause apoptosis
cytotoxic
Term
CD4 T cells
Definition
co stimulate B cells
MHC II
secretes cytokines
Term
CD4 Th1 cells
Definition
bacterial macrophages
helps B cells against intracellular parasites
Term
CD4-Th2
Definition
parasites Ige
eosinophils
extracellular parasites
Term
CD4-Th17
Definition
IL 17
automimmunity
bacteria
fungi
Term
CD4 T follicular
Definition
helps B cells
Term
Draw a T cell receptor and MHC I and II molecule
Definition
Term
each t cell close expresses 1
Definition
t CELL RECEPTOR
Term
Each t cell recognize ______ type of antigen bound to MHC
Definition
one
Term
signal transduction to the intracellular domain
Definition
CD3
Term
steps in VDJ recombination
Definition
1) germline
2) somatic recombination rag 1/2 endonucleases cleave recombination signal sequence
3) generation of hair pins
4) release of haripins to create the P nucleotides
5) N nucleotides added via Terminal deoxynucleotideal transssssraae
6) pairing of strands
7) NHEL
Term
cdr
Definition
complementary determining regions
Term
cdr1 and 2
Definition
encoded within V
Term
cdr 3
Definition
encoded junction of VDJspecificity of antigen comes from this complimentaritty determining region.
Term
sTRECs
Definition
by product of recombination
signal joiny t cell reeptor exxcision circles

useful for measuring the output of T cells by the Thymus
Term
SCID
Definition
failure of the recombination process of TCRs and Ig

results in arrested development of T cells and B cells.
Term
what kind of t cells do you get in the subscapular space
Definition
doube negative
Term
what kind of t cells do you get in the thymoc cortex
Definition
double positive
Term
what kind of t cells do you get into the thymic medulla
Definition
single positive
Term
double positive T cells have death by ________
Definition
default
Term
When does a t cell graduate from the subscapular space?
Definition
when it has acheived a sucesful b chain rearrangement

b chain succesfully expressed with a pre-T aplpha chain
Term
When does a t cell graduate from the thymi cortex?
Definition
When it expresses CD4/CD8
undergoes interaction with MHC I or MHC II
Term
What kind of sepection occurs in the thmyic cortex
Definition
positive
Term
What kind of selection goes on in thymic medulla?
Definition
negative
Term
order of t cell receptor rearrangmenet
Definition
b rearrangement stops
cell proliferates
CD4/CD8 induction
a rearrangement begins
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