Term
|
Definition
| Defective pluripotent stem cells. The patient has no lymphoid or myeloid cells and is anemic. |
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Term
|
Definition
-Deficiency of lymphocytes
-Secondary to a defect of ADA
-JAK 3 gene mutation |
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Term
|
Definition
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Term
|
Definition
Congenital abornmality in organs derived from the 3rd and 4th pharyngeal pouches including thymus. Results in a lack of T cells
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|
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Term
| Chronic Mucocutaneous Candidiasis |
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Definition
| Failure of T cells to generate a receptor for the Candida antigen |
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Term
|
Definition
| defective viral and intracellular bacterial immunity. Recognized by accumulation of large cytoplasmic granules in phagocytes with deficient lysosome activity. Also NK function is impaired. |
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Term
| Chronic Granulomatous Disease |
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Definition
|
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Term
X-Linked Agammaglobulinema
Burton's Agammaglobulinemia |
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Definition
Btk defect
Affects B cell development from pre to immature stage |
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Term
| Transient Hypogammaglobulinemia |
|
Definition
| IgG, IgA, and IgE deficiency due to decreased Th cytokine production needed for isotype switching |
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Term
| Common Variable Hypogammaglobulinemia |
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Definition
| defective antibody production following infection. Individuals have normal numbers of periperal blood B cells but there may be a block at the immature stage or a defective antigen-induced differentitation. |
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Term
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Definition
|
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Term
| Paroxysmal Nocturnal Hemoglobinuria |
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Definition
|
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Term
| Leukocyte Adhesion Deficiency (LAD) |
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Definition
|
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Term
|
Definition
Type II Hypersensitivity Response
-Antibodies directed against alpha-3 portion of type IV collagen in basement membrane of lung and kidneys |
|
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Term
| Pernicious Anemia (Type II Hypersensitivity) |
|
Definition
| -Antibodies directed against parietal gastric cells that secrete IF |
|
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Term
| Pernicious Anemia (Type III Hypersensitivity) |
|
Definition
| -Antibodies directed against the Intrinsic Factor |
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Term
|
Definition
-Antibodies bind to TSH receptor and activates it.
-Causes hyperthyroidism |
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Term
|
Definition
-Antibodies to the Ii glycoprotin on RBC
-Only manifests at temp below 37C |
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Term
| Systemic Lupus Erythematosus (SLE) |
|
Definition
-Type III Hypersensitivity
-Immune complexes are formed and deposited on basement membrane of kidneys, skin, synovia of joints,.
-Causes polyclonal B cell activation |
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Term
|
Definition
Type III Hypersensitivity
-Immune complexes on synovia of joints |
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Term
|
Definition
| -Antibodies to myelin basic protein (MBP) |
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Term
|
Definition
Type IV Hypersensitivity
-Thyroid gland destruction and production of anti-thyroglobulin antibodies
-Leads to hypothyroidism |
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