Term
|
Definition
| Rh mismatch between mother and fetus leads to a Type II hypersensitivity hemolytic anemia in the fetus. Hepatosplenomegaly, elevated bilirubin, petechiae |
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Term
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Definition
| Localized Type III hypersensitivity |
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Term
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Definition
| Type IV hypersensitivity to gliadin leading to villous atrophy in the small bowel and malabsorption |
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Term
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Definition
| autoreactive B and T cells destroy nicotinic acetylcholine receptors in the neuromuscular junction |
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Term
|
Definition
| anti-TSH receptor antibodies causes hyperthyroidism |
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Term
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Definition
| anti-platelet antibodies cause bruising and hemorrhage |
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Term
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Definition
| antibodies against the kidneys leads to glomerulonephritis, a Type II hypersensitivity reaction |
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Term
|
Definition
| Type IV destruction of the beta islet cells of the pancreas leads to inability to produce insulin. May be precipitated by a Coxsackie viral infection. |
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Term
|
Definition
| Type II hypersensitivity against epidermal cadherin leads to a blistering skin rash |
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Term
|
Definition
| anti-nuclear autoantibodies implicated in lupus and Sjogren's syndrome |
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Term
|
Definition
| lgM, IgA, IgG1 and IgG3 produced against peripheral nerve gangliosides. May be caused by antigenic cross reactivity of C. jejuni lipooligosaccharides, Mycoplasma pneumoniae, EBV, and CMV |
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Term
|
Definition
| affects more men than women, certain HLA B27 alleles increase risk |
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Term
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Definition
| Type II hypersensitivity initiated by Strep infections that attacks cardiac muscle |
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Term
|
Definition
| Type III and IV hypersensitivity mediated by IgG-rheumatoid factor complexes |
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|
Term
| Systemic lupus erythematosus |
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Definition
| Type III hypersensitivity mediated by anti-dsDNA antibodies |
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Term
|
Definition
| Type IV hypersensitivity against myelin basic protein |
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Term
|
Definition
| antibodies against anti-thyroglobulin, anti-microsomal antibodies |
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Term
|
Definition
| livedo reticularis, a lacy patterned rash that is associated with SLE and scleroderma |
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Term
|
Definition
| Type I hypersensitivity reaction leading to bronchial constriction |
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Term
|
Definition
| Type I hypersensitivity reaction leading to edema of the nasal conjunctiva |
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Term
|
Definition
| systemic autoimmune disease caused by anti-centromere antibodies |
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Term
| Bruton's Agammaglobulinemia |
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Definition
| Defective tyrosine kinase gene blocks B-cell maturation, causing failure of opsonization and recurrent bacterial infection. X-linked inheritance. |
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Term
|
Definition
| Characterized by recurrent Gram+ infections e.g. staphylococcus, increased susceptibility to Type III Hypersensitivity Reactions |
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Term
| Chronic Granulomatous disease |
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Definition
| Lack of NADPH oxidase, few reactive species, no respiratory burst. Susceptibility to catalase-positive infection. |
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Term
| Chronic Mucocutaneous candidiasis |
|
Definition
| T-cell dysfunction causes pathognomic skin infection |
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Term
| Common Severe Immune Deficiency |
|
Definition
| Multiple recurrent infections. IL-2 Receptor downregulated in X-linked disease. |
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|
Term
| Common Variable Immune Deficiency |
|
Definition
| Defects in B-cell maturation, increased risk of AI disease and lymphoma. |
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Term
|
Definition
| 22q11 deletion and failure of the 3rd and 4th pharyngeal pouches to develop, recurrent viral and fungal infections, thymic aplasia. |
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Term
|
Definition
| Caused by C1 Inhibitor Deficiency |
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Term
|
Definition
| Defect in Th1 response, decreased IFN-gamma, disseminated mycobacterial infection. |
|
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Term
| Late Complement Deficiency |
|
Definition
| Characterized by recurrent Gram- infections e.g. neisseria |
|
|
Term
| Leukocyte Adhesion Deficiency (Type 1) |
|
Definition
| Defect in CD18, delayed separation of umbilicus, neutrophilia and recurrent intracellular infection. |
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|
Term
| Neutropenia and Hyposplenism |
|
Definition
| Quantitative defects in phagocytic cells |
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