Use: suppress organ rejection after transplant, selected autoimmune disorders

Mech: binds to cyclophilins -- inhibits calcineurine --prevents production of IL-2 and it's receptor -- blocks differentiation of Tcells

Tox: viral infections, lymphoma, neprotoxic (prevent with mannitol diuresis)

Use: immunosuppressive used in organ transplant recipients

Mech: binds to FK-binding protein and inhibits secretion of IL-2 and other cytokines

Tox: BAD! nephrotoxicity, peripheral neuropathy, hypertension, pleural effusion, hyperglycemia

Use: Kidney transplant, glomerulonephritis, hemolytic anemia

Mech: antimetabolite of precursor of 6-mercaptopurine -- interferes with metabolism of nucleic acids -- toxic to prolifereating lymphocytes

Tox:bone marrow supression, toxic effects inc by allopurinol bc metabolized by xanthine oxidase

Use: immunosuppression after kidney translpant

Mech: Monoclonal AB that binds to CD3 on surface of Tcells and blocks signal transducion

Tox: cytokine release syndrome, hypersensitivity reaction

Use: kidney translpant

Mech: binds mTOR and inhibits Tcell prolif in response to IL-2

Tox: Hyperlipidemia, thrombocytopenia, leukopenia