- the Fas (CD95) receptor and its ligand belong to this family

tumor necrosis factor family

Although Fas is present on both B and T cells, Fas Ligand is not present on which one?

B cells

- this problematic use of Fas and Fas L allows this group of cells to survive pathologically

Tumor cells bearing Fas L

- the most famous of the immune privelige sites

- the site of the easiest transplantation

Eye

- the cell death receptor pathway used in apoptosis is activated by this cysteine dependent aspartate protease family

Caspase 8

- the two caspases that are directly activated by the death receptor pathway

Caspase 3 and 7

- the four ways in which Fas/Fas L can kill a cell

"point blank" (direct Fas/Fas L binding)

"suicide" (cell produces Fas L to bind to its own Fas)

" sharpshooting" (soluble Fas L binding to Fas far away)

"weapons of mass destruction" (with other means like perforin and granzymes)

- lymphadenopathy and splenomegaly are two primary symptoms of this Fas/Fas L mutational disorder

Autoimmune lymphoproliferative disorder (ALD)

- the two primary mechanisms of protection that immune priveliged sites utilize

secretion of anti-inflammatory cytokines

killing of inflammatory cells with Fas L

- these cells of the eye produce Fas L

Retinal pigment cells

Corneal endothelial cells

- this surface receptor resembles CD28 in that it binds B7, but it dampens T cell activation instead

CTLA4 (CD86)

- T cells are not activated when "self" antigens are presented under these conditions

Non-inflammatory conditions

- these molecules have to be present for T cell activation to occur

Co-stimulatory molecules

- these T cells become anergic, stop making IL-2, and become unreactive to subsequent antigen presentation after co-stimulatory molecules are blocked or absent

Tolerized T cells

- B cells require these cells to be activated

T helper cells

- Tregs express this surface receptor and inhibit CD4 and CD8 T cells

CD25

- Tregs express this transcription factor that is vital in keeping the immune response under control

Foxp3

- Tregs release these immunosuppresive cytokines

IL-10, IL-35, TGF-beta

- the four mechanisms of Treg regulation

Inhibitory cytokines

Cytolysis (granzymes)

Metabolic disruption

Modulation of DC function (CTLA4, LAG-3)