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Immune Modifying drugs and selected (HTR) associations
usmle review
30
Medical
Graduate
05/14/2009

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Cards

Term
Cyclosporine
Definition
blocks the activation of T cells by inihibiting calcineurin. preventing the production of IL-2 and it's receptor. Clinical use: organ rejection , and a few auto immune disorder. TX: viral infections and lymphoma at risk for. nephrotoxic, preventible with mannitol diuresis.
Term
Tracolimus
Definition
similar to cyclosporine, binds to FK-binding porteins, inhibiting secretion of IL-2, and other cytokines. organ transoplant receptors. Tx- significant nephrotoxicity, peripheral neuropathy, hypertension, plerual effusion, hyperglycemia
Term
Azathioprine
Definition
mech: antimetabolite precrusor of 6-mercaptopurine that interferes with the metabolism and syntehsis of neucleic acids. tx to proliferating lymphocytes. clnical use: kidney transplantation, auto immune disorders. including glomeronephrritis and hemolytic anemia (both are type II). tx: bone marrow supression. active metabolite is metablized by xanthine oxidase which is inhibited by allpurinaol so allourinol makes tx worse.
Term
OKT3
Definition
muromonab. monoclonal antibody that binds to CD3 (episolon chain on t cells. blcoks cellular interaction taht lets T cells divide. Clinicl use: kidney transplant. tx- cytokine release syndrome (give tyelenol) allergy
Term
sirolimus
Definition
binds to mTOR inhibits T cell proliferation in response to IL-2. immuno supression after kidney transplant in combo with cyclosporine and corticosteroids. tx- hyperlipidemia, htombocyto penia and leukopenia
Term
myecolophenolate mofetil
Definition
mech: inhibits de notvo guanine synth and blocks lympthoctye production
Term
daclizumab
Definition
monoclonal antibody with high affinity for Il-2 receptors on activated immue T cells
Term
IL2
Definition
renal cell carcinoma, metastatic melanoma. makes em feel like crap
Term
filgastrim
Definition
granulocyte macrophage colony stimulating facotr recovery of bone marrow after chemo
Term
alpha inteferon
Definition
Hepatitis b, c kaposi's sarcoma (hhv2) leukemias, melanoma
Term
beta interferon
Definition
multiple sclerosis (type IV hypersenstivity)
Term
thrombopoetin
Definition
thrombocytopenia
Term
Job's syndrome
Definition
lack of production of Ifn-y and lack of response of neutrophils to chemotactic agents. leads to bacterial infections. FACIES. cold staph abscesses. retained primary teeth. IGE, dermatologic problems
Term
Wiskott-aldritch
Definition
no igm production, causes up reg of iga and ige: WIPE infections, thrombocytopnic purpura, and eczema.
Term
hyper igm
Definition
lack of cd40
Term
burtons
Definition
bkt gene problem, plenty of pro bs. not enough mature b's. x linked. shit hits fan at 6mos when moms crap runs out. lots of bacterial infections
Term
ataxia telangientasia
Definition
lack of iga
Term
anti centromere
Definition
scleroderma crest
Term
anti-scl-70
Definition
scleroderma diffuse
Term
anti-desmoglein
Definition
pemphigus vulgaris (some blistering thing)
Term
anti-ss-a
Definition
sjogrens syndrome. dry everthing, inflamed parotitds, aurthritis.
Term
anti-u1 rnp
Definition
mixed connective tissue disorder
Term
antihistone
Definition
drug induced sle
Term
A3
Definition
hemochromatosis
Term
b27
Definition
pair
Term
b8
Definition
graves
Term
dr2
Definition
multiple sclerosis, hay fever, sle good pastures
Term
dr4
Definition
ra, diabetes
Term
dr5
Definition
pernicious anemia, hashimotiots
Term
dr7
Definition
steroid responsive nephrotic syndrome.
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