Term
| These drugs are transport inhibitors |
|
Definition
cholestyramine
colestipol
colsevelam |
|
|
Term
| mech of action for resins |
|
Definition
increase bile acid synth (this enhances HMG coA red
LDL rec. (uptakeing LDL) |
|
|
Term
|
Definition
decrease LDL
increase VLDL and triglyceride |
|
|
Term
|
Definition
| **heterozygous** familial and polygenic hypercholesterolemia |
|
|
Term
| What should resins be used in combination w/ if pt. has HIGH triglycerides |
|
Definition
|
|
Term
| This resin is effective for treating post-cholecystectomy diarrhea, and C. difficile diarrhea |
|
Definition
|
|
Term
|
Definition
malabsorption of ADEK
Hyper Cl met acidosis |
|
|
Term
|
Definition
| hypertriglyceridemias, diverticulitis |
|
|
Term
| Mech of action for Ezetimibe |
|
Definition
| inhibits uptake of cholesterol by interfering w/transporter |
|
|
Term
| Overall effect of ezetimibe |
|
Definition
decrease LDL-C
increase HDL-C |
|
|
Term
| Ezetimibe can act w/what to lower LDL |
|
Definition
|
|
Term
| clinical use of Ezetimibe |
|
Definition
Primary hypercholesterolemia
phytosterolemia |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| effect of resins on ezetimibe |
|
Definition
| intestinal absorption of ezetimibe is reduced. |
|
|
Term
|
Definition
partially inhibit HMG coA reduc.
induces LDL receptor
**small INCREASE in HDL**
**decrease in triglycerides** |
|
|
Term
| the pleiotrophic effects of cholesterol |
|
Definition
reduced inflammation
stabilization of plaques
reduced thrombogenic response |
|
|
Term
|
Definition
pts. at risk CAD
polygenic or familial HC
*prescribe these after CV events* |
|
|
Term
|
Definition
severe rhabdomyolysis, myoglobinuria, acute renal failure
impair mitochondria function |
|
|
Term
|
Definition
lactation and pregnancy
secondary to rhabdomyosis |
|
|
Term
| statins + fibrates cause what toxicity? |
|
Definition
|
|
Term
|
Definition
inhibit FA release from stores
decrease VLDL apolipoproteins
decrease chylos and LDL |
|
|
Term
|
Definition
all types of hyperlipoproteinemia
EXCEPT ***hypertriglyceridemia**** |
|
|
Term
|
Definition
atrial fibrillation
incr. uric acid
flushing |
|
|
Term
|
Definition
DM
peptic ulcer
gout
hepatic dz |
|
|
Term
| Niacin does what to anti HTN's |
|
Definition
|
|
Term
|
Definition
|
|
Term
| mech of action for fibrates |
|
Definition
ligand for PPARa
decr VLDL and tri's,
LDL and cholesterol to a lesser extent
***increases HDL**** |
|
|
Term
| What are fibrates used for |
|
Definition
very HIGH serum triglyceride [ ]
DOC |
|
|
Term
|
Definition
cholelithiasis and cholecystitis
flu like syndrome |
|
|
Term
|
Definition
| anticoag effect of warfarin. |
|
|
Term
| what are some inducers of CYP3A4 |
|
Definition
| Carbamazepine, phenytoin, phenobarbital, rifampin, St. John's wort |
|
|
