Term
| Metastatic bone disease treatment |
|
Definition
-bisphosphonates
-Denosumab
-calcitonin |
|
|
Term
|
Definition
-human monoclonal antibody for metstatic bone disease
-NOT for multiple myeloma
-AE-hypocalcemia, ostenecrosis of jaw, nausea, anemia, dyspnea, fatigue, constipation |
|
|
Term
| Treatment for Hypercalcemia of Malignancy |
|
Definition
-Hydration
-furosemide
-bisphosphonates
-calcitonin
-corticosteroids
-IV phosphate
-Cinacalcet |
|
|
Term
|
Definition
-bisphosphonate (moderate to severe)
-more potent than pamidronate--more patients achieve normal calcium
-use carefully if SCr > 4.5 |
|
|
Term
|
Definition
-bisphosphonate (moderate to severe)
-effective & well tolerated
SE-fever, flu-like symptoms, venous irritation |
|
|
Term
|
Definition
-for ACUTE control of calcium levels
-rapid onset
-mild to moderate hypercalcemia |
|
|
Term
|
Definition
-useful in lymphoproliferative malignancies for hypercalcemia of malignancy
-used for Ca++ refractory to bisphosphonates |
|
|
Term
|
Definition
| -used in hypercalcemia of malignancy if unresponsive to other agents |
|
|
Term
|
Definition
| -used in hypercalcemia of malignancy if unresponsive to other agents. |
|
|
Term
|
Definition
-uused in treatment of hyperuricemia
AE-anaphylaxis, hemolysis (G6PD deficiency), methemoglobinemia |
|
|
