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Human Physiology
Physiology Power Point 3 Membrane Dynamics
33
Physiology
Undergraduate 2
03/15/2013

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Cards

Term
Cell membrane structures and functions
Definition

Membranes form fluid body compartments

Membranes are barriers and gateways

Membranes distribute water and solutes in cells and the body

Chemical and electrical imbalances

Membrane permeability and changes

Term
Fluid Mosaic Model Contains
Definition

Phospholipids

Integral Proteins

Peripheral Proteins

Glycoproteins - MHC and Glycolipids

Cholesterol

Term
Inorder for something to pass through the phospholipid bilayer
Definition

It needs to be very small

Needs to be a lipid - nonpolar

Term
Integral Proteins
Definition

are gate, channel pores

5 protein glob

can pass medium size molecular weight

water - polar molecules

ions

Term
Second Messenger System
Definition

1. Protein hormones bond to the peripheral protein causing a shape change

2. When the integral protein changes shape the internal 3. peripheral protein changes shape

4. Adenylate Cyclase converts ATP

ATP converts to CAMP + PO4

Term
Single solid protein
Definition
Peripheral Protein
Term
Cycocalyx
Definition

glycolipid

glycoprotein

Term
Adenylate Cyclase
Definition
When the internal peripheral protein changes shape
Term
MHC
Definition
Major Histocompatability Complex
Term
3 types of passive transport
Definition

1. Simple diffusion

2. Osmosis

3. Facilitated diffucion (mediated transport)

Term
3 types of active transport
Definition

1. co-transport

2. vesicular transport

3. receptor mediated transport

Term
Concentration from high to low across a semi permiable membrane, no external energy needed?
Definition
Simple diffusion is from high to low concentration
Term
Properties of simple diffusion
Definition

uses energy of the concentration gradient

movement occurs till equilibrium is reached

direct correlation to temp

indirect correlation to molecule size

slower diffusion with increased distance

lipophilic molecules can diffuse through the phospholipid bilayer

Term
In ..... diffusion the protein gate helps push the molecule across the membrane.
Definition
Facilitated Diffusion
Term
Tonicity
Definition
The number of particles in a solution
Term
The movement of water from high concentration to low concentration
Definition
Osmosis
Term
Low concentration of particles to high concentration of particles
Definition
Osmosis
Term
Crenated?
Definition
Dehydrated
Term
Isotonic solution
Definition
no change in cell
Term
Hypertonic solution
Definition
cell shrinks
Term
Hypotonic solution
Definition
cell expands
Term
Pure water solution is ?
Definition
Hypotonic
Term
Active transport
Definition

Moves from low concentration to high concentration

ATP is needed

creates a state of disequilibrium

 

Term
1 degree active transport
Definition

ATP energy directly fuels transport

uniport and antiport

Term
2 degree indirect active transport
Definition

uses concentration gradient for energy

symport and antiport

Term
Symport
Definition

molecules are carried in same direction

examples Glucose and Na

Term
Antiport
Definition
Molecules are carried in opposite directions
Term
Vesicular Transport
Definition
Movement of macromolecules across cell membrane
Term
Properties of Vesicular Transport
Definition

1. Phagocytosis - macrophage or phagocytes

2. Pinocytosis - cell drinking

3. Receptor mediated endocytosis - down regulation

4. Exocytosis

Term
Properties of Phagocytosis
Definition

requires energy

cell engulfs particle into vesicle via pseudopodia formation

vesicles formed are larger than those formed by endocytosis

phagosomes fuse with lysosome

Term
Endocytosis
Definition

nonselective - pinocytosis for fluids and dissolved substances

selective - receptor mediated endocytosis via clathrin coated pits. ie. LDL cholesterol and familial hypercholesterolemia

Term
Receptor Mediated Endocytosis
Definition

No 1. uptake method in most cells

receptors and the substance is internalized

clathrin coated vesicle

down regulated

Term
Exoxytosis
Definition

intracellular vesicle fuses with cell membrane

requires ATP and Ca2+

used on waste removal

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