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Human Behavior
Anxiety and Somatization
48
Medical
Graduate
10/08/2009

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Term
What are the basic classifications of anxiety?
Definition
It is universal, normal and adaptive; it is hardwired - separation, strangers, falling, typical threats; it is acquired - conditioned responses; it is linked to two systems: fight flight freeze and vigilance, persistent arousal
Term
How do we deal with a stimulus?
Definition
notice (alert), assess, and react
Term
Where does anxiety happen in the brain?
Definition
Perception: periphery to frontal cortex; evaluation: subcortical structures (amygdala, hippocampus); reaction: brain stem centers
Term
What is paroxymal anxiety?
Definition
SNS revs up, PNS turns off; cortisol produced; regulated by serotonin
Term
What is persistent anxiety?
Definition
low grade elevation of SNS, often with low cortisol
Term
How is anxiety regulated?
Definition
cortisol reduces central NE, negative auto feedback, GABA, serotonin, cortical modulation (thought, defenses)
Term
What is the "end organ" anxiety symptomatology?
Definition
Brainstem is telling organs that something is wrong, so patients complain of heart, lung, or gi system problems.
Term
What can persistent stress cause?
Definition
ulcers, arteriosclerotic cardiovascular disease (ASCVD), immune mediated disorders (lupus), depression
Term
What are the psychological aspects of stress?
Definition
􀁻 Sudden or unrelenting demand
􀁻 Subjective helplessness
􀁻 Ominous meaning
􀁻 Anticipation of negative
consequences
􀁻 Lack of coping skills, immature
defenses
􀁻 Both triggers for and manifestations
of stress responses
Term
What are the common elements of DSM anxiety disorders?
Definition
anticipation, arousal, and avoidance
Term
What is panic disorder?
Definition
Uncued panic,
catastrophic interpretation of
physical sensation, anticipation and
agoraphobic avoidance
Term
what is social phobia?
Definition
panic + blushing,
expectation of humiliation or hurt,
yearning and social isolation
Term
What needs to be right in the anxiety disorder diagnosis?
Definition
patient, symptoms, genes, right back story, natural history, typical response to treatment, no medical reason
Term
What are the validators of social phobia?
Definition
􀁻Sensitizing social experiences
􀁻 Discipline through humiliation
􀁻 Rejection by peers
􀁻 Disfigurement
􀁻 Interpersonal victimization or
trauma
Term
What are the social phobia pearls?
Definition
􀁻 Unusual sex ratio—men seek
treatment more than women
􀁻 Related to cultural pressure to be
gregarious or sequestered
􀁻May be a problem in professional
training
􀁻 Risk factor for Alcohol abuse
Term
What are the validators for panic disorder?
Definition
􀁻 Less clear role of development
􀁻 Rely more on full symptom picture,
demographics, family history
􀁻 Agoraphobic avoidance and
relational behavior
Term
What are the panic disorder pearls?
Definition
􀁻 Accounts for enormous unnecessary
medical expense
􀁻 Not clearly associated with suicide
EXCEPT when panic attacks occur
with depression
􀁻 Panic+Depression:Malignant suicide
predictor
Term
What are some general characteristics of PTSD?
Definition
􀁻 Combat, rape, accident and natural
disaster
􀁻 Exposure: equal but sequelae seen
in women slightly more than men
􀁻 Triad of intrusive, numbing and
arousal symptoms
􀁻 Physical symptoms often less
patterned than those of panic,
medically unexplained physical symptoms (MUPS)
Term
What is anticipation?
Definition
this element is cognitive, and involves the affected individual as judging a particular situation as frightening or dangerous
Term
What is arousal?
Definition
this is the panic one feels in response to the scary/dangerous situation.
Term
What is avoidance?
Definition
This is the behavioral component to anxiety
Term
What is a panic attack?
Definition
discrete period in which there is a sudden onset of intense apprehension, fearfulness, or terror, often associated with feelings of impending doom. During these attacks, symptoms such as shortness of breath, palpitations, chest pain or discomfort, choking or smothering sensations, and a fear of “going crazy” or losing control are present
Term
What is a panic disorder (with and without Agoraphobia)
Definition
characterized by recurrent panic attacks about which there is persistent concern. May be present in the context of Agoraphobia – meaning that the fear of having a panic attack in public becomes so great that the individual is afraid to leave “comfortable” situations (i.e. the home, may be afraid to go places alone, etc)
Term
What is a specific phobia?
Definition
characterized by clinically significant anxiety provoked by exposure to specific fear object of situation, often leading to avoidance behavior.
Term
What is generalized anxiety disorder (GAD)?
Definition
characterized by at least 6 months of persisent and excessive worry and anxiety. It is not limited to any one aspect of individual’s life…rather it is generalized
Term
How does one evaluated PTSD?
Definition
􀁻 Social history should include enquiry
about stress and trauma, esp if person
describes functional symptoms (cardiac,
GI, pain, respiratory and dizzyness)
􀁻 Specific symptom enquiry: nightmares,
forced recollection, amnesia, distance,
loss of future orientation, startling,
irritability, disrupted sleep
Term
What should happen in primary care in respect to paroxysmal anxiety disorders?
Definition
recognize, educate, encourage,
self-help. Monitor outcome and refer if higher
level of care needed
Term
What drugs are good for paroxysmal anxiety disorders?
Definition
antidepressants and antianxiety
medications in particular.
Term
What should be counseled against in paroxysmal anxiety disorder?
Definition
substance abuse and avoidance
Term
What is non-paroxysmal anxiety disorder?
Definition
􀁻Generalized anxiety
􀁻 Persistent arousal: Tension, disrupted
sleep, appetite and gi disturbance, aches
and pains, sighing, jumpiness
􀁻 Promiscuous worry: everything is
threatening, catastrophic interpretations
􀁻 Negative expectations
􀁻 Helplessness
􀁻 High comorbidity with depression
􀁻 Panic if present not prominent
Term
What does treatment of generalized anxiety disorder look like?
Definition
some different meds than paroxysmal, tries to enhance sense of control, confronts catastrophic thinking, extends range of function, uses psychotherapy and support
Term
What is somatization?
Definition
􀁻 Bodily manifestations of emotion
􀁻 Worldwide, taken for granted
􀁺 European cultures, more psychologizing
􀁻 May prompt request for relief
􀁺 Relief of symptom vs addressing cause
􀁺 Context affects emotional expression,
often hard to change
Term
What are the DSM somatoform disorders?
Definition
􀁻 Somatizaton disorder
􀁻 Conversion disorder
􀁻 Factitious disorder
􀁻 Malingering
􀁻 Body dysmorphic disorder
􀁻 Pain disorder
Term
What is somatization disorder?
Definition
* Polysymptomatic disorder that begins before 30 that is characterized by a combination of pain, GI, sexual, & pseudoneurologic symp. That cannot be explained fully by any known general medical condition or substance

Pt. has:
* 4 pain symptoms (history of pain related to 4 diff. sites of function)
* 2 GI symptoms (e.g. nausea, diarrhea, food intolerance)
* 1 sexual symptom (e.g. sexual dysfunc., menstrual abnormalities)
* 1 pseudoneurologic symptom (e.g. impaired coordination, localized weakness, double vision)
Term
What is conversion disorder?
Definition
* Unexplained symptoms affecting voluntary motor or sensory function that suggest a neurological or other general medical condition

* Psychological symptoms are associated with symptoms

* Clear relationship found between stressor & the initiation of symptom
Term
What is factitious disorder?
Definition
A self inflicted illness for "primary" (unconscious) gain
Term
What is malingering?
Definition
Feigned illness for “secondary” gain
􀁺 Escape
􀁺 Disarm aggression, prevent abandonment, elicit
care, compensation
􀁺 Drug seeking
􀁺 Common in military and prison populations
Term
What are known stress related syndromes?
Definition
􀁻 Migraine Headaches
􀁻 Irritable bowel
􀁻 Fibromyalgia/chronic fatigue
􀁻 Pelvic pain
􀁻 Obesity
􀁻 Major depression
Term
What is the epidemiology of stress syndromes?
Definition
􀁻 Female predominance 2:1
􀁻 Early age of onset
􀁻 Extensive comorbidity
􀁻 Role of stress, both current and
prior
􀁻 Social roles that discourage open
expression of emotion
Term
What is the Dx, Tx, and referral for stress syndromes
Definition
􀁻 Any suspected symptom or disorder
should prompt search for others (add
mood, energy to review of systems)
􀁻 Genetic/family history of depression,
anxiety or substance use
􀁻 Evaluate of current stress (cause and
consequence of symptoms)
􀁻 Evaluate of sensitizing experiences: loss,
trauma, illness in self or family
Term
What are bad reasons for testing?
Definition
􀁺 Anger, frustration on part of HCP
􀁺 Desire to prove others wrong
􀁺 Cultural insensitivity
􀁺 Patient demand without other grounds for test
Term
What is hypochondriasis?
Definition
* Preoccupation with the fears of having or the belief that one has a serious disease as a result of misinterpreting bodily symptoms & functions

* Fear or idea of having a disease despite medical reassurance; the belief is NOT of delusional intensity
Term
What is body dysmorphic disorder?
Definition
* Preoccupation w/an imagined or exaggerated defect in physical appearance

* Non-delusional, however, in that they can acknowledge that their concerns may be exaggerated

* If delusional intensity pt. may be diagnosed with Delusional Disorder Somatic Type
Term
What is pain disorder?
Definition
* Pain in one or more sites is the predominant focus of the clinical presentation

* Psychological factors have important role in the onset, severity, exacerbation, or duration of the pain

* Three subtypes: pain assoc. psychological factors, with psychological factors & medical condition, and with a General Medical Condition (not a mental disorder)
Term
Obsessive-Compulsive Disorder
Definition
characterized by obsessions (persistent ideas, thoughts, impulses, or images that are experienced as intrusive and which cause marked anxiety or distress) and/or by compulsions (repetitive behaviors of which the goal is to prevent or reduce anxiety or distress – NOT to provide pleasure or gratification). It is important to note that the obsessions and compulsions may be related (i.e. obsessions of cleanliness/germs, compulsion of handwashing) or not related (i.e. obsessions of blasphemous thoughts; compulsions of counting to ten forwards and backwards)
Term
Undifferentiated Somatoform Disorders
Definition
Same as somatization disorder, but less stringent criteria

3 pain symptoms instead of 4
Term
Somatoform Disorder Not Otherwise Specified
Definition
Somatoform disorders that do not meet criteria for other diagnosis

E.g. Pseudocyesis: false belief of being pregnant that is assoc. w/signs of pregnancy (including abdominal enlargement, reduced menstrual flow, amenorrhea, etc.)
Term
Alexithymia
Definition
the inability to express emotion
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