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How Cells Divide
Mitosis and Meosis
57
Biology
Undergraduate 2
03/06/2006

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Term
What depends on cell division?
Definition
Growth and reproduction.
Term
In cell division, what must parent cells provide ?
Definition
Their daughter cells DNA and enough cytoplasmic machinery to start up their own operation.
Term
What are the types of cell division in eukaryotic cells?
Definition
Mitosis and Meiosis
Term
What is the type of cell division in prokaryotic cells?
Definition
Prokaryotic fission
Term
Cell division in prokaryotes takes place in two stages, what are they?
Definition
1. The DNA is replicated

2. The cell elongates, then splits into two daughter cells

The process together is called binary fission

Term
Why is cell division in eukaryotes more complex than in prokaryotes?
Definition
1. Eukaryotic contain far more DNA

2. Eukaryotic DNA is packaged differently

Term
How is eukaryotic DNA packaged?
Definition
It is in linear chromosomes compacted with proteins.
Term
Eukaryotic cells divide in one of two ways and with different cells...what are they?
Definition
Mitosis : Occurs in somatic (non-reproductive) cells

Meiosis: Occurs in germ (reproductive) cells

Term
What does Meosis produce?
Definition
Results in the production of gametes
Term
What increase...and what duplicates in the cell cycle?
Definition
During cycle, cell increases in mass and duplicates its chromosomes.
Term
Cell Cycle Diagram
Definition
[image]
Term
What are the stages of a Eukaryotic cell?
Definition
G1 phase: Primary growth phase

S phase: DNA replication

G2 phase: Microtubule synthesis

M phase: Chromosomes pull apart

C phase: Cytoplasm divides

Term
What are the 4 characteristics of interphase?
Definition
1. Usually longest part of the cycle

2. Cell increases in mass

3. Number of cytoplasmic components doubles

4.DNA is duplicated

Term
What are the stages of interphase?
Definition
G1: Interval or gap after cell division
S: Time of DNA synthesis (replication)
G2: Interval or gap after DNA replication
Term
What are the stages of mitosis?
Definition
Prophase

Metaphase

Anaphase

Telophase

Term
What is mitosis usually followed by?
Definition
cytoplasmic division
Term
Hwo many chormosomes are in each species?
Definition
The number of chromosomes varies enormously from species to species.
Term
What is the name of the chromosmal pair?
Definition
Chromosomes exist in somatic cells as pairs also called homologous chromosomes or homologues.
Term
Chromosomes
Definition
Chromosomes are molecules of DNA complexed with proteins (histones).

Between divisions, each threadlike chromosome is duplicated to form sister chromatids.

Chromatids are joined by a centromere—the region where the chromosome will attach to microtubules during nuclear division.

Term
What are Diploid cells ?
Definition
Have two copies of each chromosomes
Term
What are the chromosomes held topgether by?
Definition
A centromere
Term
How many chromosome do humans have?
Definition
Humans have 46 chromosomes

The 23 pairs of homologous chromosomes can be organized by size

This display is termed a karyotype

Term
What are chromosomes made of?
Definition
Chromosomes are composed of chromatin

Complex of DNA (~ 40%) and proteins (~ 60%)

A typical human chromosome contains about 140 million nucleotides in its DNA

In the cell, however, the DNA is coiled

Term
What are histones?
Definition
The DNA helix is wrapped around positively-charged proteins, that the DNA helix is wrapped around.
Term
What is a nucleosome ?
Definition
200 nucleotides of DNA coil around a core of eight histones.
Term
Solenoids
Definition
What the nucleosomes coil
Term
Looped Domains
Definition
What solenoids are organized into.
Term
What is the eukaryaotic stages?
Definition
Interphase
Mitosis
Division of the nucleus, also termed karyokinesis
Subdivided into Prophase, metaphase, anaphase, telophase.
Cytokinesis - division of the cytoplasm
Term
Spindle Apparatus
Definition
Consists of two distinct sets of microtubules - Each set extends from one of the cell poles.

Two sets overlap at spindle equator Moves chromosomes during mitosis

Term
What happens to chromosomes during interphase?
Definition
Chromosomes replicate and begin to condense.
Term
What happens during prophase?
Definition
Nuclear envelope breaks down

Chromosomes condense further

Spindle apparatus is formed

Term
What happens during metaphase?
Definition
Chromosomes align along the equatorial plane

Spindle fibers attach at the kinetochores

On opposite sides of the centromeres

Term
What happens during anaphase?
Definition
Sister chromatids separate

They are drawn to opposite poles by shortening of the microtubules attached to them

Term
What happens during telophase?
Definition
Nuclear envelope reappears

Chromosomes decondense

Spindle apparatus is disassembled

Term
Cytokinesis
Definition
Two diploid daughter cells form
Term
Cleavage furrow
Definition
Pinches the cell in two. In an animal cell.
Term
Cell plate
Definition
Divides the cell in two.
Term
Gametes (chromosomes)
Definition
(Eggs and sperm) contain half the complement of chromosomes found in other cells
Term
What is the fusion of gametes called? And what does it create?
Definition
Fertilization or syngamy

It creates the zygote, which contains two copies of each chromosome

Term
What does sexual reproduction contain?
Definition
Involves the alternation of meiosis and fertilization., however Asexual reproduction does not.
Term
What does the life cycles of all sexually-reproducing organisms include?
Definition
It follows the same basic pattern.

Haploid cells or organisms alternate with diploid cells or organisms

Term
What stages does meoisis seperate?
Definition
Meiosis I
Separates the two versions of each chromosome

Meiosis II
Separates the two sister chromatids of each chromosome

Term
What deoes meoisis do to the number of chromosomes?
Definition
Meiosis halves the number of chromosomes
Term
List all the stages of meoisis?
Definition
Meiosis I

Prophase I
Metaphase I
Anaphase I
Telophase I
Meiosis II

Prophase II
Metaphase II
Anaphase II
Telophase II

Term
What does each stage of meiosis 1 do?
Definition
Prophase I
Homologous chromosomes pair up and exchange segments

Metaphase I
Homologous chromosome pairs align at random in the equatorial plane

Anaphase I
Homologous chromosomes separate and move to opposite poles

Telophase I
Individual chromosomes gather together at each of the two poles

Term
What are the characteristics of Meiosis I and Prophase I?
Definition
The longest and most complex stage of meiosis
Term
What does homologous chromosomes undergo?
Definition
Synapsis, they pair up along their lengths.

Crossing over occurs.

Term
What happens after Meiosis I?
Definition
A brief interphase----No DNA synthesis occurs
Term
Meiosis II is similar to mitosis, but what are the two main differences?
Definition
1. Haploid set of chromosomes

2. Sister chromatids are not identical

Term
What are the stages of Meiosis II?
Definition
Prophase II
Brief and simple, unlike prophase I

Metaphase II
Spindle fibers bind to both sides of the centromere

Anaphase II
Spindle fibers contract, splitting the centromeres Sister chromatids move to opposite poles

Telophase II
Nuclear envelope reforms around four sets of daughter chromosomes

Term
Let's compare meiosis and mitosis?
Definition
Meiosis and mitosis have much in common

However, meiosis has two unique features

1. Synapsis
Homologous chromosomes pair all along their lengths in meiosis I

2. Reduction division
There is no chromosome duplication between the two meiotic divisions This produces haploid gametes

Term
Let's compare meiosis and mitosis?
Definition
Meiosis and mitosis have much in common

However, meiosis has two unique features

1. Synapsis
Homologous chromosomes pair all along their lengths in meiosis I

2. Reduction division
There is no chromosome duplication between the two meiotic divisions This produces haploid gametes

Term
What are the evolutionary consequences of sex?
Definition
Sexual reproduction increases genetic diversity through three key mechanisms

1. Independent assortment

2. Crossing over

3. Random fertilization

Term
What is Independent assortment?
Definition
In humans, a gamete receives one homologue of each of the 23 chromosomes

Humans have 23 pairs of chromosomes

223 combinations in an egg or sperm 8,388,608 possible kinds of gametes

Term
Crossing over
Definition
DNA exchanges between maternal and paternal chromatid pairs

This adds even more recombination to independent assortment that occurs later

Term
Random fertilization
Definition
The zygote is formed by the union of two independently-produced gametes

Therefore, the possible combinations in an offspring

8,388,608 X 8,388,608 =

70,368,744,177,664
More than 70 trillion!
And this number does not count crossing-over

Term
Importance of Generating Diversity
Definition
Genetic diversity is the raw material that fuels evolution

And no genetic process generates diversity more quickly than sexual reproduction

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