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HIV Meds SE
HIV meds and their important side effects
31
Pharmacology
Graduate
03/08/2014

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Cards

Term
Abacavir
Definition
Hypersensitivity reactions
Term
Didanosine
Definition
Peripheral Neuropathy
Pancreatitis
Take on empty stomach
Term
Emtricitabine
Definition
Skin hyperpigmentation
Term
Lamuvidine
Definition
None bolded
Term
Stavudine
Definition
Peripheral neuropathy
Pancreatitis
Term
Tenofovir
Definition
Decreased bone marrow density
Renal Dysfunction (Faconi Syndrome)
Term
Maraviroc
Definition
Hepatotoxcity
Infection
Malignancy
Tropoism Testing
CYP3A4 substrate only
Term
Enfuviritide
Definition
SQ admin - local injection site rxn
Broken down in blood
Term
Zidovudine
Definition
HA
Anemia
Neutropenia
Term
NRTIs
Definition
Lactic acidosis
Severe hepatomegaly with steatosis
TEAL have least risk
Term
Efavirenz
Definition
CNS problem - empty stomach QHS
Rash
Pregnancy category D
Term
Etravirine
Definition
Rash
Hypersensitivity
Term
Neviripine
Definition
Rash
Hepatotoxicity (do not give if CD4 > 250 in females, >400 in males)
Term
Rilpivirine
Definition
Rash
Hepatotoxicity
Term
NNRTIs
Definition
Rash
Do not need renal adjustment
Term
Raltegravir
Definition
Myopathy/CPK elevation
Rash
Term
Elvitegravir
Definition
Decreased bone marrow density
Only in combo Stribild (emtricitabine, tenofovir, and cobicistat - inhibit 3A4 for increased levels)
Term
Dolutegravir
Definition
Hypersensitivity (rash)
Must increase to BID dosing if given with potent UGT or 3A4 inducer or integrase inhibitor resistance mutations
Term
Atazanavir
Definition
Indirect hyperbilirubinemia
Nephrolithiasis
Prolonged PR interval
Term
Darunavir
Definition
Rash (sulfa allergy)
Always given with ritonavir
Term
Fosamprenavir
Definition
Rash
Nephrolithiasis
Term
Indinavir
Definition
Nephrolithiasis
Give on empty stomach
Term
Lopinavir/Rigonavir
Definition
Kaletra
GI intolerance
Prolonged PR/QT interval
Term
Nelfinavir
Definition
Give with food
Diarrhea
Term
Ritonavir
Definition
Only given as PK booster
Parsthesias
Term
Saquinavir
Definition
With Food
Always with ritonavir
Prlonged PR/QT interval
Term
Tipranavir
Definition
Always with ritonavir
With Food
Increased LFTs
Rash
Rare intracranial hemorrhag
Term
Protease Inhibitors
Definition
Hyperglycemia
Fat maldistribution
Lipid abnormalities
Increased bleeding episodes
(Metabolic syndrome)
AFI drugs - adequate hydration
Term
Drugs not to use with rifampin
Definition
Nevirapine
Etravirine
Rilpivirine
Maraviroc
Elvitegravir/Cobicistat
Term
Drugs that interact with warfarin
Definition
Efavirenz
Nevirapine
Etravirine?
Elvitegravir/Cobicistat
Term
Zidovudine Interactions
Definition
Co-trimoxazole/Ganciclovir
Possible synergistic bone marrow toxicity
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