Protease inhibitor

Dose:  400/100mg bid

SE:  hyperlipidemia (TG), increased liver enzymes

refridgerator

Protease Inhibitor

Dose:  1400mg + RTV 200mg daily

SE:  Rash, hyperlipidemia

Caution in sulfa-allergic patients

TPV

Protease Inhibitor

Dose:  500mg + ritonavir 200mg bid

SE:  rash, hepatitis, transaminitis

NFV

Protease Inhibitor

Dosing:  1250mg bid or 750mg tid

SE:  transaminitis

Protease Inhibitor

Dosing:  1000mg + RTV 100mg bid

SE:  PR and QT prolongation, hepatotoxicity, transaminitis

Protease Inhibitor

SE:  crytaluria causing AKI (crystalizing in kidney)

Drink lots of water!!

RAL

Integrase Inhibitors

Dose:  400mg bid

SE:  myalgias, CPK elevations

MVC

CCR5 Antagonists

Dosing:  300mg bid or 150mg bid with 3A4 inhibitors

SE:  hepatoxicity, coughing spells, fever and rash

Have to do Tropism testing prior (make sure they have the CCR5 virus before you give this)

Stribild (Quad)

What 4 drugs?

Cobicistat

MoA?

Inhibits metabolism of elvitegravir

Makes elvitegravir work better

Fusion Inhibitors

Dose:  90mg SQ bid

SE:  injection site reactions, increased risk of bacterial pneumonia

SubQ!

TDF

Nucleoside reverse transcriptase inhibitors

Dose:  300mg daily

SE:  nephrotoxicity, reduced bone mineral density

stopping therapy may cause HBV flares

FTC

Nucleoside reverse transcriptase inhibitors

Dose 200mg daily (capsule), 240mg daily (solution)

SE:  hyperpigmentation of palms/soles

Stopping therapy may cause HBV flares

AZT

Nucleoside reverse transcriptase inhibitors

Dose:  300mg bid or 200mg tid

SE:  BMS (macrocytic anemia or neutropenia), hyperpigmentation, lactic acidosis

renally cleared

ABC

Nucleoside reverse transcriptase inhibitors

Dose:  300mg bid or 600mg daily

SE:  life-threatening rash with fever, respiratory distress, GI, SOB

Test for HLA-B 5701, if + do not use due to increase risk of hypersensitivity reaction

Not used in patients with baseline viral load > 100k

3TC

Nucleoside reverse transcriptase inhibitors

Dosing:  150mg bid or 300mg daily

SE:  pacreatitis

stopping may increase HBV flare

ddl

Nucleoside reverse transcriptase inhibitors

Dosing:  >60kg:  400mg daily, <60kg:  250mg daily

SE:  pancreatitis, peripheral neuropathy, optic neuritis

d4t

Nucleoside reverse transcriptase inhibitors

Dosing:  >60kg:  40mg bid, <60kg:  30 bid

SE:  fatal lactic acidosis, lipodystrophy, peripheral neuropathy, hyperlipidemia, DM, rapid neuromuscular weakness

Rash

Resistance to one = resistance to class

EFV

non-nucleoside reverse transcriptase inhibitors

SE:  insomnia, vivid nightmares

CI in 1st trimester of pregnancy

NVP

non-nucleoside reverse transcriptase inhibitors

Dosing:  200mg daily for 14 days then 200mg bid

SE:  life-threatening rash, hepatotoxicity

CI in women with CD4 > 250 or men >400

ETV

non-nucleoside reverse transcriptase inhibitors

Dose:  200mg bid

SE:  peripheral neuropathy, rash including SJS

RPV

non-nucleoside reverse transcriptase inhibitors

combined with tenofovir and emtricitabine = Complera

Dose:  25mg daily

SE:  depression, insomnia, fat redistribution

ATV

protease inhibitors

Dosing:  300mg of ATV + ritonavir (RTV) 100mg daily

SE:  hyperbilirubinemia, rash, prolong QT, fat redistribution, nephrolithiasis

Do not give with PPIs due to decrease absorption (>20mg of omeprazole)

DRV

protease inhibitors

Dosing:  800mg plus ritonavir (RTV) 100mg daily

SE:  rash including SJS, DM, liver enzymes

has sulfonamide moiety

protease inhibitors

Dose:  400mg/100mg bid

SE:  hyperlipidemia, liver enzymes

FPV

protease inhibitors

Dose:  1400mg + ritonavir (RTV) 200mg daily

SE:  rash, oral paresthesias, hyperlipidemia, hypertriglyceridemia, fat redistribution

TPV

protease inhibitors

Dose:  500mg + ritonavir 200mg bid

SE:  rash, hepatitis, transaminitis

NFV

protease inhibitors

Dose:  1250mg bid or 750mg tid

SE:  transaminitis, phenylketonuria

SQV

protease inhibitors

Dose:  1000mg + ritonavir 100mg bid

SE:  PR and QT prolongation, hepatotoxicity, transaminitis