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HIV docking
Dr. David Senchina, Drake University, Medical Microbio virus unit
6
Microbiology
02/12/2010
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Term
What are the two important glycoproteins in HIV docking?
 Definition
gp41 and gp120
Term
gp 120
 Definition
Docks first onto CD4, then onto coreceptor X4 or 125
Term
gp41
 Definition
"Hypodermic needle" shaft that enters the T cell to unload its genetic material after gp120 has bound
Term
BMS805
 Definition
Bristol-Myers Squibb
Blocks gp120 from binding to CD4
Term
SCH-C
 Definition
Schering-Plough
Blocks gp120 from binding to coreceptor
Term
T20
 Definition
FDA-approved in March 2003
Blocks gp41 from binding to host cell membrane