Term
| tissues and organs w/o lymphatic drainage |
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Definition
CNS
Bone Marrow
Inner Ear
eye
Cartilage |
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Term
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Definition
| connectie tissue framework in which various "lymphoid" cells are suspended. |
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Term
| connective tissue framework is made up of ... |
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Definition
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Term
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Definition
fibroblasts which produce reticular fibers (type III - collagen)
characteristic of lymphoid tissues |
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Term
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Definition
made up of reticular fibers
secreted from reticular cells
lymphoid tissue |
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Term
| list lymphoid cells (cells found in lymphoid tissue) |
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Definition
reticular cells
T and B-lymphocytes
plasma cells
macrophages (APCs) |
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Term
| non-encapsulated lymphatic tissue |
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Definition
lamina propria (CT of digestive, urinary, and respiratory systems)
solitary lymph nodule (spherical mass of lymphatic tissue; not permanent |
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Term
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Definition
infiltration of lymphocytes into the LP of the digestive, urinary, and respiratory systems
non-encapsulated lymphatic tissue |
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Term
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Definition
non-encapsulated lymphatic tissue
dense aggregates of lymphatic tissue forming spherical mass
contains reticular cells, reticular fibers and lymphocytes
usually found in loose CT assoc with epithelium; line passageways continuous with the external environment
their size and/or numbers increase during humoral responses |
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Term
| solitary lymph nodule - locations ?? |
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Definition
*present in LP of non-encapsulated lymphatic tissues*
lamina propria of GI system (GALT)
urinary system
respiratory system (MALT and BALT) |
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Term
| solitary lymph nodule - structure?? |
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Definition
MANTLE (cortex): outer, densely-staining region; has small T and B lymphocytes
GERMINAL CENTER: reactive center; lighter staining region; large cells undergoing proliferation and lymphoblast transformation (B cells, PCs & RCs) |
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Term
| DARK zone (germinal center) |
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Definition
non-activated B cells
centroblasts
T-Cells
Dendritic Cells |
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Term
| LIGHT ZONE (germinal center) |
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Definition
centroblasts --> centrocytes
follicular dendritic cells
macrophages
(activate B cells here with FDC) |
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Term
| brief summary of B cell maturation process in nodule |
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Definition
centroblast (dark zone) --> migrate to light zone centroblasts --> centrocytes (in light zone) centrocyte activated by FDCs in light zone - B cell becomes activated |
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Term
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Definition
APCs of the skin
when presented with foreign antigen, they migrate to distant nodules where they become dendritic cells
interact in dark zone with T-cells and immature B-cells (centroblasts) |
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Term
| aggregates of nodules called... |
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Definition
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Term
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Definition
aggregates of nodules
groups of solitary lymph nodules
characteristically found in lamina propria of the ileum opposite the attachment of mesentery.
GALT |
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Term
| Partially-encapsulated lymphatic organs |
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Definition
tonsils
organs surrounded by a CT capsule AND partially by the epithelium lining the oral cavity.
the tonsils drain by efferent vessels primarily into the deep cervical lymph nodes |
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Term
| describe tonsils in general |
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Definition
they are partially-encapsulated lymphatic organs
internal connective tissue framework (TRABECULAE)
infoldings of the surface epithelium
3 types --> palatine, lingual, pharyngeal
function of tonsils = lymphopoiesis, antibody production |
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Term
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Definition
location: (btwn palatoglossal arch and palatopharyngeal arch)
lymphatic tissue - dense and nodular
surface covering - stratified squamous epithelium which invaginates into the tonsil as multiple CRYPTS
CT - hemi-capsule from which trabeculae partition the tonsil itself
assoc mucous glands - drained by ducts bypassing the tonsilar crypts to empty directly onto the surface |
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Term
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Definition
| the three tonsilar groups form ring around entrance to the throat |
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Term
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Definition
location: root of the tongue posterior to the row of vallate papillae
lymphatic tissue: dense and nodular lymphatic tissue
surface covering: stratified sqyamous epithelium which invaginates as a SINGLE crypt into each lingual tonsil.
CT - hemi-capsule
assoc mucous glands - drained by duct draining directly into the single tonsillar crypt |
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Term
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Definition
location: posterior wall of nasopharynx (pharyngeal recess
lymphatic tissue: dense and nodular
surface covering: pseudostratified columnar epithelium which invaginates into the tonsil as multiple folds (NO CRYPTS0
CT - hemi-capsule
assoc seromucous glands: drained by ducts emptying into the epithelial folds |
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Term
| encapsulated lymphatic organs |
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Definition
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Term
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Definition
lymph sinuses - channels for the movement of ymph through the node; no endothelium; loose areas of LT interlaced by many reticular cells/fibers
cortex - lymph nodules;paracortical region/deep cortex
medulla - medullary cords and sinuses
lymphatic vessels - afferent/efferents
blood vessels - enter at HILUS; in trabeculae
nerves - only vasomotor (sm. m.)
funciton - lymphopoiesis; antibody prod; filter lymph
medulla
lymphatic vessels
blood vessels
nerves
function |
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Term
| spleen (general characteristics) |
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Definition
complete connective tissue capsule
parenchyma - white and red pulp
blood supply: splenic a. --> capsular a. --> trabecular a --> central arterioles --> penicilliary arterioles --> sinusoids --> postcapillary venule --> trabecular veins --> splenic vein |
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Term
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Definition
| splenic a. --> capsular a. --> trabecular a --> central arterioles --> penicilliary arterioles --> sinusoids --> postcapillary venule --> trabecular veins --> splenic vein |
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Term
| margination and subsequent diapedesis |
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Definition
| cytokines stimulate margination of arterioles in spleen |
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Term
white pulp of spleen
what are PALSs? |
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Definition
T cells surrounding the central arterioles (brought be cytokine stimulation)
reactive B cells form nodules with reactive centers
central arterioles displaced peripherally by these nodules (called eccentric central arterioles
Periarteriolar lymphatic sheath (PALS) - mass of T cells around central arterioles in spleen |
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Term
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Definition
| barrel-sphated splenic SINUSOIDS surrounded by macs, reticular cells, lymphocytes. |
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Term
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Definition
filters blood (phags and cords of billroth)
hematopoiesis (mainly lymphocytes and monocytes)
phagocytosis of RBCs
antibody production
blood reservoir |
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Term
| thymus general characteristics |
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Definition
bi lobed
complete capsule
cortex and medulla in juvenile but not in adult
NO NODULES - no B cells!
epithelial reticular cells (APCs; thymopoietin)
Hassall's corpuscles (adult only; degenerating epithelial reticular cells) |
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Term
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Definition
composed of epithelial reticular cells (ERCs)
ERCs are APCs and function to support and isolate the thymocytes they surround; they synthesize and secrete thymopoietin and other paracrine factors to regulate T cell development
no nodules |
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Term
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Definition
thicker ERCs = reduced density of lymphatic tissue (T cells)
degenerating ERCs result in Hassall's corpuscles |
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Term
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Definition
blood distributed via septae to capillaries in parenchyma
HEVs represent sites of margination and diapedesis of immature T cells |
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Term
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Definition
lymphopoiesis (esp fetus/infant)
maturation of T cells
removal at birth will cause severe lack of lymphocytes and immune response in the infant |
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Term
type of lymphatic vessels in lymph nodes??
afferent, efferent, both? |
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Definition
| both afferent and efferents |
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Term
type of lymphatic vessels in spleen??
afferent, efferent, both? |
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Definition
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Term
type of lymphatic vessels in thymus??
afferent, efferent, both? |
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Definition
EFFERENTS ONLY
like spleen |
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