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Histology Midterm
definitions
160
Veterinary Medicine
Graduate
09/23/2007

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Term
Parenchyma
Definition
cells which make the functional units of an organ
Term
Stroma
Definition
the connective tissue framework associated with the epithelium
Term
Serosa
Definition
specialized epithelia and its associated connective tissue which line the external surfaces of body tubes with an external connection and secrete a watery-type secretion
Term
Mucosa
Definition
specialized epithelia and its associated connective tissue which line the luminal surfaces of body tubes with an external connection and secrete thick viscous fluid
Term
Functions of epithelium
Definition
Protection, absorption, excretion, secretion, surface reception, reproduction
Term
Mesothelium
Definition
line the inner surfaces of some body cavities, and outer surfaces of internal organs
Term
Glycocalyx
Definition
a coating of glycoproteins and other complex sugars which cover the external surface of the apical plasma membrane
Term
Axoneme
Definition
a cylindrical array of microtubules, consisting of 9 “doublets” of microtubules around two single centrally located microtubules
Term
Reticular cells
Definition
function as “fixed” (not readily mobile) fibroblasts which synthesize reticular fibers (type III collagen); in lymphoid organs
Term
Pericytes
Definition
capable of migrating away from the vessel and differentiating into other CT cells (fibroblasts /smooth muscle cells)
Term
Type I collagen
Definition
Collagen type found in skin, bone, tendons, ligaments, and other interstitial spaces (course fibers)
Term
Type II collagen
Definition
Collagen type found in cartilage, nucleus pulposus (spinal column), and the vitreous body (eye)(fine fibers)
Term
Functions of Connective Tissue Proper
Definition
connect, suspend, form, thermodynamically insulate and mechanically cushion, site of food storage (energy), & important in repair and regeneration
Term
Functions of Adipose Tissue
Definition
conservation of heat and mechanical cushioning, also an important energy store (more energy pr gm); fat metabolism
Term
Perichondrium
Definition
region which separates from and physically binds the cartilage to the surrounding non-collagenous tissue; like a “capsule” in other organs
Term
Osteon
Definition
structural unit of bone formed by concentric layers around a central canal
Term
Central Canal
Definition
a center of osteon – contains blood vessels, vasomotor nerves, and lining cells called endosteum
Term
Lamellae
Definition
Concentric layers of bony matrix
Term
Perforating Canals
Definition
act to interconnect longitudinally arranged central canals with each other and the internal medullary cavity of the bone (lined with endosteum)
Term
Interstitial Lamellae
Definition
fragments of partially degraded, no Haversian Canal
Term
Sarcolemma
Definition
plasmalemma of a muscle cell
Term
Sarcosome
Definition
mitochondria of muscle cells
Term
Myofibril
Definition
group of muscle myofilaments
Term
Myofiber
Definition
a single muscle cell, made up of multiple myofibrils, which are in turn made up of myofilaments
Term
Sarcomere
Definition
Structural and contractile unit of muscle
Term
Red Fiber
Definition
slow twitch or type I fiber (slower contractile cycles)
Term
White Fiber
Definition
fast twitch or typeII fiber (rapid contraction cycles)
Term
Caveolae
Definition
Invaginations of the plasma membrane in smooth muscle to facilitate movement of Ca in and out of cell
Term
Endomysium
Definition
CT fibers and matrix surrounding each individual myofiber
Term
Perimysium
Definition
surrounds bundles (groups) of myofibers, call fascicles
Term
Epimysium
Definition
surrounds organized groups of fascicles (anatomically discrete muscles) – referred to as fascia
Term
Nerve
Definition
Nerve cell processes in the PNS
Term
Tract
Definition
Nerve cell processes in the CNS
Term
Nuclei
Definition
Collection of nerve cell bodies in the CNS
Term
Ganglia
Definition
Collection of nerve cell bodies in the PNS
Term
Neuropil
Definition
a complex network of nerve cell processes and connective tissue in which nerve cell bodies of the CNS are embedded
Term
What do euchromatic nuclei look like and are they active or inactive
Definition
They are light staining with basic dyes and are active
Term
What do heterochromatic nuclei look like and are they avtive or not
Definition
Tightly coiled chromosomal material that stains deeply during interphase and is believed to be genetically inactive.
Term
intramembranous bone formation
Definition
bone that is formed within embryonic connective tissue without a cartilaginous model precursor, replacement of loose connective tissue
Term
endothelium
Definition
type of epithelium that lines vessels and is simple squamous epothelium
Term
mesothelium
Definition
type of epithelium that lines all body cavities, and is simple squamous epithelium
Term
all serosal surfaces of the small intestine are lined by what
Definition
mesothelium lines all serosal serfaces in the small intestine
Term
goblet cells are also called what, and what do they secrete
Definition
called unicellular glands, and secrete mucus
Term
what purpose does mucus serve
Definition
lubricate the passage of ingesta
Term
Brush border
Definition
microvilli lining the simple columnar epithelium of the proximal renal tubules of the kidneys is referred to as the brush border.
Term
striated border
Definition
The microvilli lining the simple columnar epithelium of the small intestine is referred to as the striated border
Term
mesenchyme cells
Definition
pleuripotntial stem cells that can develop into any connective tissue cell
Term
extracellular matrix
Definition
made up of fibers (collagen, elastic and reticular) and amorphous ground substance
Term
what type of cells secrete extracellular matrix
Definition
connective tissue cells
Term
appositional growth
Definition
chondroprogenitor cells in cellular layer of the perichondrium give rise to chondroblasts that secrete extracellular matrix onto preexisting cartilage
Term
interstitial growth
Definition
chondrocytes out in the matrix undergo division
Term
what is elastic cartilage
Definition
composed of hyaline cartilage frame that is reinforced with elastic fibers
Term
what is fibrocartilage
Definition
lacunae are key to recognizing it, found in carious location, particularly areas of transition from hyaline cartilage to tendons or ligaments
Term
telodendria
Definition
extensive branching at the termination of an axon
Term
grey matter
Definition
nervous tissue at CNS containing nerve cell bodies
Term
endoneurium
Definition
collagenous fibers and CT matrix between individual, adjacent nerve fibers
Term
choroid plexus
Definition
specialized ependymal cells ing the ventricles that contribute to the formation of the cerebrospinal fluid
Term
3 anatomic classifications of neurons and describe how different
Definition
unipolar- one axon that bifricates
bipolar- two axon processes
multipolar- several axons and dendrites
Term
3 apical surface modifications and describe their function
Definition
cilia- aid in the movement of material
stereocilia- increase surface area and absorption
microvilli- increase surface area and absorption
Term
plasma cell
Definition
the cell chiefly responsible for synthesizing circulating antibodies
Term
collagen type IV
Definition
specific type of fiber (lattice) located exclusively in basement membranes, adhesive in properties, not fibrillar
Term
mesenchymal cells
Definition
referred to as an undifferentiated, stellate shaped cell, these cells are pleuripotent and have the ability to differentiate into other CT cells
Term
meninges
Definition
collective term for the connective tissue coverings around the central nervous
Term
t-tubule
Definition
the structure responsible for bringing the action potential to the level of each sarcomere (activate the sarcoplasmic reticulum)
Term
osteoid
Definition
the organic substance first laid down by an osteoblast before it is infiltrated with hydroxyapatite
Term
erosion lacunae
Definition
space between osteoclast and the bony surface
Term
dense bodies
Definition
attachment points for bundles of smooth muscle myofilaments, this is analogous to the Z line in skeletal and cardiac muscle
Term
myoconducting fibers
Definition
modified cardiac muscle fibers- longer and paler staining, conduct nerve impulses within the myocardium
Term
list luminal structures an O2 molec would pass, starting from larynx to type I pneumocyte in the lung.
Definition
larnyx..trachea.. bronchi.. bronchial.. alveolar duct.. alveolar sac.. pulmonary alveolus
Term
list 3 catergories of arteries and describe their structure and function
Definition
arterioles- primary control of systemic blood pressure (control the distribution of blood to capilary)
elastic- conducting, large amounts of elastic fibers and function to maintain even flow and constant blood pressure
muscular- distributing, internal elastic membrane is usually highly convoluted, and functions to regulate volume in response to functional demand
Term
three types of cells found in specialized sensory epithelium and the vomeronasal organ
Definition
sustenacular (supportive)
basal (progenitor)
olfactory (neurosensory)
Term
lymph flows into a lymph node by way of a ..... lymphatic vessel
Definition
afferent
Term
the lymph enters the ..... space/sinus just bebeath the limiting connective sissure border of the node.
Definition
subcapsular
Term
the lymph then flows through the ..... between lumphatic nodules to the ..... which is bound by the medullary cords rich in..... lumphocytes.
Definition
cortical sinus
medullar sinus
b-lumphocytes
Term
lymph exits the lumph node via ..... lymphatic vessels
Definition
efferent
Term
list the 3 types of granular leukocytes and the basic differences between them ( what is the dye affinity of each, not the color)
Definition
neutrophil- neutral, no color
eosinophil- acidic, acidiophilic, red/pink
basophil- basic, basophilic, blue/purple
Term
two architectural types of bone
Definition
spongy,cancelous, trabecular

compact, cortical
Term
the primary cell type that makes up the bulk of the cells in the parenchyma of the thymus
Definition
t-cells
Term
t-cells are supported by a cellular scaffolding within the parenchyma, these cells are called
Definition
epithelio-reticular cells
Term
4 classifications of connective tissue proper
Definition
dense irregular connective tissue
dense regular connective tissue
loose irregular connective tissue
adipose tissue
Term
an organized collection of nerve cell processes that form a definable anatomical structure is called a __ peripherally PNS and a __ centrally CNS. nerve cell bodies are often found in clusters or groups and have common functions. inside the CNS these coll
Definition
nerve
tract
nuclei
ganglia
Term
two major components that make up the matrix of cartilage
Definition
fibers (type II collagen)
proteoglycans (chondroitin sulfate)
Term
reticular cells
Definition
large, stellate shaped cells located in lymphoid organs and bone marrow which synthesize type III collagen
Term
artifact
Definition
the structure which is not normally part of a tissue but is created during the making of the slide, a false structure
Term
dendrites
Definition
extensions of nerve cell body, and act to increase its surface area and enhance points of contact with other neurons (input region)
Term
mast cells
Definition
very large cell usually round but sometimes fusiform depending upon tissue site contains large amounts of heparin, histamine granules, plus proteases and esterases
Term
perichondrium
Definition
region which separates from and physically binds the cartilage to the surrounding non-collagenous tissue, like a capsule in other organs composed of dense irregular CT surrounds all hyaline cartilage except articular surfaces
Term
canaliculi
Definition
connect adjacent lacunae and enable cell-cell contact between osteocytes
Term
skeletal muscle: location of nuclei? fiber shape? innervation?
Definition
peripherally located
unbranched
voluntary
Term
cardiac muscle: location of nuclei? fiber shape? innervation?
Definition
centrally located
branched
involuntary
Term
smooth muscle: location of nuclei? fiber shape? innervation?
Definition
centrally located
fusiform
involuntary
Term
red pulp sinus
Definition
high concentration of red cells
Term
PALS
Definition
surrounds central arteries
Term
thymic corpuscles
Definition
acidophilic whorls unique to the thymus
Term
splenic trabeculae
Definition
often contains smooth muscle
Term
splenic nodule
Definition
germinal centers in spleen
Term
splenic cords
Definition
in between sinuses of red pulp
Term
subcapsular space
Definition
inflow space of node from afferent lymphatic
Term
secondary nodule
Definition
germinal center
Term
arrange in order according to direction of blood flow through the spleen: ventral artery, venous sinus, trabecular artery, sheathed artery, splenic artery
Definition
splenic artery
trabecular artery
central artery
sheathed artery
venous sinus
Term
intramembranous ossification
Definition
replacement of loose CT with bone, no cartilage model/template
Term
endochondral ossification
Definition
replacement of hyaline cartilage template with bone
Term
4 supportive cells of the CNS (central glial cells)
Definition
astrocytes
microglia
oligodendrocytes
ependymal cells
Term
if you were to prepare a blood smear from a healthy dog the two most common leukocytes expected to find would be...
Definition
neutrophil
lymphocyte
Term
if you were to prepare a blood smear from a healthy bovine the two most common leukocytes expected to find would be...
Definition
lymphocyte
Term
lumen
Definition
space contained within a tube, cylinder or sphere
Term
6 functions of epithelium
Definition
protection
absorption
excretion
secretion
surface reception
reproduction
Term
3 types of intercellular junctions
Definition
anchoring
occluding
communicating
Term
4 types of surface modifications
Definition
microvilli
stereocilia
cilia
flagella
Term
axoneme
Definition
a cylindrical array of microtubules, consisting of 9 doublets of microtubules around two single centrally located microtubules
Term
connective tissue components
Definition
cells, fibers, ground substance
Term
types of collagen fibers
Definition
type I
type II
type III
type IV
type V
Term
type I collagen fibers
Definition
coarse fibers, most abundant, 90% body collagen, found in skin, bone, tendons, ligaments and other interstitial spaces
Term
type II collagen fibers
Definition
fine fibers, found in cartilage, nucleus pulposus and vitreous body(eye)
Term
type III collagen fibers
Definition
reticular fibers, not easy to see without special stain, synthesized by epithelial cells, fibroblasts and smooth muscle cells
Term
type IV collagen fibers
Definition
lattice, located exclusively in basement membranes, synthesized by epithelial cells
Term
endochondrial ossification
Definition
replacement of hyaline cartilage
Term
4 zones of endochondral ossification
Definition
resting cartilage
zone of proliferation
zone of hypertrophy
zone of calcification
Term
3 types of cartilage
Definition
hyaline cartilage
elastic cartilage
fibrocartilage
Term
lacunae
Definition
found in cartilage and bone, cavity containing chondrocytes, cells divide and form isogenous groups or cell nests
Term
canaliculi
Definition
microchannels withing the matrix that allow contact with adjacent osteocytes/blasts
Term
endosteum
Definition
inner cellular covering of bone, covers all inner surfaces- including the trabeculae and osteonal canals
Term
periosteum
Definition
outer covering of bone- highly vascularized and innervated (pian)
Term
most predominant cell type in periosteum
Definition
fibroblast
Term
Z line of sarcomere
Definition
acts to anchor actin filaments, dark thin lines
Term
A band of sarcomere
Definition
composed of centrally overlapping actin an myosin filaments at either end of the band and myosin alone in the center
Term
I band of the sarcomere
Definition
composed of the Z line and the actin filament ends at either pole of two adjacent sarcomeres, (space on either side of a Z line)
Term
H band of sarcomere
Definition
composed of myosin only in the center of the sarcomere
Term
M line of sarcomere
Definition
center or sarcomere, composed of tails of thick myosin filaments
Term
endomysium
Definition
CT fibers and matrix surrounding each individual myofiber
Term
perimysium
Definition
surrounds bundles of myofibers called fascicles
Term
epimysium
Definition
surrounds organized groups of fascicles
Term
perikaryon
Definition
portion of the cell body immediately surrounding the nucleus, typically highly granular and basophilic
Term
dendrites
Definition
extensions of the nerve cell body and act to increase its surface area and enhance points of contact with other neurons, generally much shorter than axons
Term
neuropile
Definition
term used to describe complex network of nerve cell processes and connective tissue in shich nerve cell bodies of the CNS are embedded, typicaly organized into functional groups called TRACTS which occupy specific regions of CNS
Term
neurolemmocytes
Definition
responsible for the formation of myelin
Term
astrocytes
Definition
very large nucleus, numerous thick processes, lie adjacent to blood vessels
Term
oligodendrocytes
Definition
neurolimmocyte equivalent in the CNS. smaller than astrocyte, few processes
Term
microglia
Definition
origin appears to be the nonocyte,
Term
ependymal cells
Definition
specialized epithelial cells that line the neural canal of the spinal cord and the 4 ventricles of the barain.
Term
4 memingial layers
Definition
dura matter
arachnoid
pia matter
blood brain barrier
Term
tunic pattern for blood vessels
Definition
tunica interna-intima, internal elastic membrane
tunica media- smooth muscle in circular pattern
tunica externa-adventicia, external elastic membrane, blends into surrounding CT
Term
three types of capillaries
Definition
continuous- continuous BM, lacks pores
fenestrated- fluid transport
sinusoidal- swiss cheese, discontinuous in BM, parenchyma of liver
Term
list the different tunics of the respiratory system
Definition
tunica mucosa- lamina epithalialis, lamina propria, lamina muscularis
tunica submucosa
tunica muscularis
tunica adventitia- when blended with trachea
Term
what is the propria submucosa
Definition
when no real definition between layer of smooth muscle for the lamina muscularis
Term
4 parts to the nasal cavity
Definition
vestibular region
respiratory region
olfactory region
volmeronasal organ
Term
what are the major changes that occur from the bronchi to the bronchioles
Definition
no cartilage, less smooth muscle, epithelium changes, no glands
Term
air pathway from trachea
Definition
trachea, bronchi, bronchioles, terminal bronchiole, respiratory bronchiole, alveolar duct, alveolar sac, pulmonary alveolus, type I pneumocyte, type II pneumocyte
Term
3 cells of the immune system
Definition
lymphocytes, stromal cells, antigen presenting cells
Term
GALT
Definition
gut associated lymphoid tissue, peyers patches of the young of certain species
Term
primary lymphoid organs
Definition
bone marrow, thymus
Term
secondary lymphoid organs
Definition
lumph nodes, spleen, MALT mucosa associated lymphoid tissue
Term
what is the significance of the pig lymph node
Definition
the organization is reversed, nodules in center, cords peripheral, flow inters the hillus and emerges in the capsular regions
Term
what is the flow within the lumph node
Definition
enters afferent lumphatics into subcapsular sinus into coritcal sinuses (in between nodules) to medullary sinuses (which are continuous with cortical sinuses) out via the efferent lymphatica at the hillus
Term
what is the arrangement of the medulla in the lymph node
Definition
diffuse lymphoid tissue organized into branching lymphatic strands or medullary cords which are rich in B-lymphocytes, cords are surrounded my medullary sinuses
Term
functions of lymph nodes
Definition
produce lymphocytes, filter lymph and produce antibodies
Term
flow through the vasculature of the spleen
Definition
splenic artery, trabecular arteries, central arteries, penicillus
Term
three types of spleen
Definition
defensive
storage
intermediate
Term
functions of spleen
Definition
immunologic defense- lymphocytes and antibodies
storage of red blood cells
filter blood- removal of worn out RBCs
Term
MALT structures
Definition
palatine tonsil
lingual tonsil
phanyngeal tonsil
peyers patches (GALT)
cloacal bursa
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