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Histology block 1
Nucleus
17
Other
Professional
05/22/2007

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Term
Heterochromatin
Definition
aggregated chromatin- nuclei inactive- dark stain
fibroblast
Term
Euchromatin
Definition
Transcriptionally active- nuclei active- light stain
fibrocyte
Term
Components of nucleus
Definition
nuclear envelope
nuclear matrix
nucleolus
chromatin
Term
neoplasm
Definition
new growth- malignant/benign - TUMOR
Term
nuclear envelope
Definition
2 parallel unit membranes around perinuclear cisterna

inner layer= lamins a, b, c - breakdown when cell in division-phosphorylation of lamina by lamin kinase during prophase mitosis initiate nuclear disassembly into small vesicle

outer layer- ribosomes attached- continuous with RER- sythesized proteins temp stored in perinuclear cisterna
Term
Nuclear Pore Complex
Definition
in nuclear envelope- where inner/outer layers fuse together

form circ gaps - 3 parts each with 8 subunits

cytoplasmic ring- Protein transport
mucleoplasmic ring- form nuclear basket with fibers extended in nucleoplasmic margin- RNA transport

middle ring- interposed between the two

receptor mediated transport- naterials have nuclear localization segments recognized by NPC: requires exporin/imporin proteins
**regulated by G protein- Ran
Term
chromatin
Definition
basophilic- responsible for RNA sythesis

dispersed/peripheral/nucleolus

condense for division- composed of 2 coiled DNA strans- 2 proteins/histones/nonhistones (reg DNA function)

Solenoid- 6 nucleosomes around axis
Term
sex chromatin
Definition
in females- one X chromosome is inactive- heterochromatic

Barr body- planoconvex mass on peripherary of inner surf nuclear membrane

drumstick- white blood cells
nucleolar satellite-neurons (mass round nucleolus)
Term
DNA
Definition
long- double strand
deoxyribose sugar, phosphate,base (pyrimidine ct purine ag)
h bonds between base pairs
Term
exons- genes
Definition
dna regions - segments- code special region
Term
intron
Definition
between exons- no code for RNA
Term
codon
Definition
3 base sequence for single aa code
Term
genome

karyotype
Definition
total genetic complement of individual in chromosome

number/characteristics of individ chromosomes
Term
nucleolus
Definition
round- basophilic- rich in RNA/protein

disappear in cell division- imp in rRNA synthesis

pars granulosa contain precursor granules of RS

pars fibrosa contain fine filament- precursor of rRNA

nucleolar organizer regions- transcript RNA
Term
nuclear matrix
Definition
amorphous- same chem as cytoplasm

ribonucleioproteins particles
nucleoskeleton- continuous fibrillar structure
Term
Meiosis
Definition
replicate 1- divide 2

prophase of M1: leptotene, zygotene, pachytene, diplotene,
DIAKINESIS- dna segment crossover occurs
Term
Disorders of chromosome
Definition
Klinefelter- 47xxy
turner - 46 xo
down (trisomy #21) - 3 #21 chromosomes
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