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HHD Ventilation Perfusion Rela
west chapter 5 and kao
17
Medical
Professional
04/08/2009

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Term
______ is responsible for most of the defective gas exchange in pulmonary diseases
Definition
mismatch of ventilation and blood flow
Term
two causes of impairment of gas exchange
Definition
hypoventilation and shunt
Term
by the time oxygen enters lung what is its pp
Definition
150 mmHG
Term
by the time the oxygen has reached the lungs what is the partial pressure of hemoglobin?
Definition
Term
the rate of PO2 in the alvoli is relatively stable from breath to breath due to the fact that
Definition
tidal volume is a relatively small portion of the total lung volume
Term
rate of alveolar PO2 is largely determined by the level of alveolar ventilation
Definition
Term
Four causes of hypoxemia
Definition
hypoventilation
diffusion limitaiton
shunt
ventilation-perfusion inequality
Term
when the systemic arterial blood reaches the tissue capillaries, o2 diffuses to the mitochondira, wher ethe PO2 is much
Definition
lower
Term
causesof hypoventilation
Definition
morphine and barbituate
damaget ot chest wall
paralyiss of respiratory muscles
high resistance to breathing
Term
respiratory exchange ration R
Definition
co2/o2
Term
ventilation increases____ from top of lung to bottom

blood flow increases more
Definition
slowly
rapidly
Term
v/q ration high or low at top of lung
Definition
high
Term
upper lung values of
pco2, po2, v/q, o2 in, co2 out, R ration
Definition
upper lung ph 7.51,
PO2 134
pCO2 20
V/Q high 3 something
02 in 4
CO2 out 8
R=2
Term
lower lung values of
pco2, po2, v/q, o2 in, co2 out, R ration
Definition
po2, 54
pco2 45
V/Q low fractional
co2 out 30
o2 in 60
R=.5
Term
uniformly ventilated and prefused lugn would tranfer more/less o2 and po2
Definition
more
Term
if the same amount of gas are beign trasnfereed the lung with ventilation-perfusion inequality cannot maintain as high an arterial PO2 or as low and arterl Pco2 as homogenous lung
Definition
Term
if you have a low v/q ration you are going to drop teh po2 of the blood more htan a high v/q ratio will raise it
Definition
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