Term
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Definition
ADP inhibitor
-inhib the G-ptn PY12 (Gi) signaling to increase cAMP levels (inhibitory in platelets) |
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Term
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Definition
ADP inhibitor
-inhib the G-ptn PY12 (Gi) signaling to increase cAMP levels (inhibitory in platelets) |
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Term
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Definition
| Blocks conversion of arachindonate -->PGG2 by acetylating COX1 irreversibly |
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Term
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Definition
| Targets Xa for anticoagulation (Xa activates prothrombin with Va cofactor) |
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Term
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Definition
| targets VKORC (Vit K epoxide reductase) so Vit K can't be reduced back to its active form |
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Term
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Definition
Acenocoumarol, phenprocoumon, dicoumarol
-Target VKORC (Vit K epoxide reductase) so vit K can't be reduced back to its active form |
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Term
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Definition
Thrombin inhibitors
-used to treat HIT (heparin-induced thrombocytopenia) |
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Term
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Definition
Rx for HUS and TTP
Binds C5, blocks formation of C5a and MAC (C5b-9)
C3a still made - weak anaphylatoxin, immune complex clearance, opsonization
Co-administer prophylactic Abx since meningococcal infection still possible |
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