Term
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Definition
- Originate in the bone marrow & circulate through lymphoid tissues
- Granulocytes (Neutro-, Eosino-, Baso- phils)
- Agranulocytes (Lymph- & Mono- cytes)
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Term
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Definition
- Neuts: main pathogen-fighting cells (most) Live 4-5 days in body tissues
- Eos: help control allergic responses & fight parasites Live 3 weeks
- Basos: release heparin, histamine, & other inflammatory mediators Live 3-7 days
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Term
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Definition
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•Lymphs:antigen-recognition & immune response; can live many years, 3 types
•B: make antibodies
•T: control immune response; cell-mediated immunity
•NKC: kill antigenic cells
•Monos: antigen-presenting cells; live 3-7 days, make inflammatory mediators (largest)
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Term
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Definition
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•↓ WBC: Neut <1500/μL
•mild (1000/μL)
•moderate (500-1000/μL)
•severe (<500/μL)
•@ Risk for gram (+) & (-) bacteria & fungi infections
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Term
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Definition
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•↑ WBC 12,000-18,000/μL (60% lymphs)
•Self-limiting B-cell lymphoproliferative disorder; Epstein Barr virus (EBV) or non-EBV link
•Life-time symptom-free infection
•Mainly adolescents/ young adults
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Term
Neutropenia
(s/s, treatment, testing)
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Definition
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•Diagnostic (Dx) testing – WBC diff
•Symptoms (S/S)
•From asymptomatic to frequent infections & fever
•Usual treatment
•Antibiotics
•G-CSF
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Term
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Definition
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•Risk factors
•Crowded conditions
•Direct close contact
Etiology
Tainted saliva
Dx testing – WBC Diff, heterophil antibodies
S/S
•Insidious onset, incubation 4-8 weeks
•Prodrome (malaise, anorexia, chills), followed by fever, pharyngitis, lymphadenopathy
•Hepato/spleno -megaly
•Usual treatment
•Bed rest & analgesics
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Term
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Definition
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•S/S – Type & stage related
•Indolent (slow-growing)
•Painless lymphadenopathy
•Aggressive (fast-growing)
•Fever, chills, night sweat
•Wt loss, pruritis
•Infection susceptibility
•Chest discomfort
•Usual treatment
•Local radiation, combination chemo
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Term
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Definition
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•Risk factors
•Radiation, benzene & chemo expo
•Genes (Down, Neurofibroma, Fanconi)
•Dx testing
•Blood/bone marrow
•Cytogene studies
•Imaging
•S/S
•anemia, fatigue, fever, night sweats, Wt loss, bleeding, bone pain & tenderness
•Usual treatment
•Chemo
•Bone marrow/stem cell transplant
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