AVAST me BIRDBATH CLAMS

B: Bowel CA

I: IV

R: rhuMAB = recomb humanized monoclonal AB to VEGF

D: Diarrhea

B: Blood clots and strokes

A: Angiogenesis inhibitor

T: T 1/2 = 17 - 21 days

H: HTN

C: Colorectal CA

L: Lung CA

A: Avastin

M: Monoclonal AB

S: Stomatitis

Commet Infant with it's flapping limbs

C: Constipation

O: Originally for preggers

M: Myelosuppresion

M: Multiple Myeloma

E: anti-Emetic @ first

T: Teratogenic

I: Immunomodulator

N: Neuropathy

F: Fatigue

A: Angiogenesis inhibitor possibly

N: use in Newly diagnosed Multiple Myeloma (vs Lenalidomide in pts that have already tried something else)

T: Thalidomide

abort the INAPT PUMP

I: IkB not degraded

N: Novel Tx

A: monoclonal Ab

P: Peripheral neuropathy

T: Thrombocytopenia

P: Proteosome (26s) is inhibited

U: Ubiquinated proteins are not proteolysed

M: Multiple Myeloma

P: p53 not degraded

Get fit @ TIP OF my AGENDA

T: TK inhibitor

I: Interstital lung disease = rare

P: p450s

O: use when Other tx have failed

F: Fecal

A: Acne like rash

G: Gefitinib

E: EGF-R Tk inhibitor

N: Nonsmall cell lung CA

D: Diarrhea and Nausea

A: monoclonal Ab

Dasani is an AMBATCHES GOD (type of egyptian tree)

A: AML

M: Melena

B: Bone marrow suppresion

A: Arrythmias

T: TK inhibitor

C: CML (blast crisis)

E: Edema

S: SRC/ABL imit resistant ones

G: GI stromal tumors

O: Oral

D: Dasanitib

I might be BETTING ON CHIFF

B: BRC-ABL!!!

E: Edema

T: Thrombocytopenic

T: TK inhibitor

I: Imitinib

N: Nausea and vomitting

G: GI stromal tumors

O: Oral

N: Neutropenia

C: CML in blast crisis

H: Hepatotoxic

I: Impair confirmation of ABL kinase = resistance

F: Fluid retention

F: Fecal

Take bisphosphonates as palliative care OR BOMB your bone

O: Osteonecrosis of Jaw

R: Renal dysfunction and GI sx

B: Bone problems: osteoporosis, pagets of bone, bone fragility, etc...

O: Osteoclast inhibitor: can't chew up the bone :-)

M: Myliple myeloma

B: Bone mets (esp w/breast CA)

I said RETUX that BRICABRACA PANFISH yea!

B: B cell apoptosis

R: Rituximab

I: IV

C: Chills

A: Arythmias

B: Bronchospasm

R: Rumor lysis syndrome (acute renal fail, hyperkalemia, hypocalcemia, hyperuricemia, hyperphosphatemia)

A: Angioedema
C: CLL
A: monoclonal Ab against CD20 on B's

P: Post-transplant lymphoma
A: ADMIN SLOWLY!!!
N: NHL
F: Fever
I: Immunosuppression
S: SLOWLY ADMIN
H: Hypotension

BITCHING APACHE

B: no cross BBB

I: IV

T: Traztumab

C: Cardiomyopathy (decrease LV fxn, CHF)

H: Her2+ Breast CA

I: Induces endocytosis of receptor
N: NK recruitment
G: Growth factor blocked

A: monoclonal Ab to EGF receptor (decrease angiogenesis and Her2 function)
P: PTEN deficiency = resistance (50% of breast cancers are PTEN deficient)
A: Antracyclins and cyclophos makes cardiomypoathy worse
C: Chills
H: H/D/N/V
E: Estrogen INDEPENDENT breast cancers

 a HALF HAKIM (egyptian folk singer)

BD TIC

H: Hairy cell LK

A: Alpha
L: Leukocytic
F: Follicular

H: Hep B and C
A: Anti-Viral
K: Karposis Sarcoma
I: IFN
M: Melamona

T: T lymphos (delta)

I: IFN

C: CT (MS in beta)

DIMWITS CARMEN LAFIA

D: Depression (alpha)
I: IV
M: Malaise
W: Wt loss
I: IM
T: THrombocytopenia

C: increase Cytotoxicity of lymphocytes
A: Activate lots
R: RNA-ase
M: MO
E: when binds makes Enzyme
N: NKs

L: Leukopenia
A: Alopecia
F: Fever w/chills
I: IFN
A: Antiviral w/little renal excretion

Bypass blocked DHFR enzyme to replenish folate pool

Admin to prevent really back SE's of long-term methotrexate or 5-FU use