DISBRANCH CHIA COIN

D: Destroy proliferating lymphoid cells

I: IM

S:Strands of DNA, and RNA bound together

B: cross BBB

R: Renal excretion

A: Amenorrhea (SE)

N: N/V

C: Cardio-toxic

H: Hemorrhagic cystitis

C: Cross linking strands

H: Hepatic Metabolism

I: IM

A: Alkylating Agent

C: Cyclophosphamide

O: Oral

I: Intracavity
N: NON-cycle specific

Bubba Chopping A Scab

B: Busulfan

U: Urine excretion

B: Break DNA via cross linking

B: Bifunctional

A: ALkylating Agent

C: CML tx

H: Hepatic Metabolism

O: Oral

P: Pulmonary Fibrosis

P: hyper-Pigmentation

I: IV

N: Non-cycle specific

G: GI distress

A: Across the BBB

S: Stystemic absorption leads to

C: Carbonium Ions

A: Allergic reaction

B: Bone marrow suppresion

Very reactive chemial moity binds to bases of DNA causing dmamge thats hard to repair (sometimes irreparable)

Busulfan, Cyclophosphamide

Nuceloside triphosphates = too polar to enter cell thus must take the drugs into cell as prodrugs then activate them

All are structural analogs of normal bulding blocks of DNA (either incorrectly incorporated into DNA to halt production or inhibit enzymes inovled in syntehsis of DNA building blocks)

ONLY work during S phase of cell cycle

Methotraxate, 6-Mercaptopurine, 5-FU

BADMAN BANDANA

B: Brompton's Cocktail

A: Agonist partial: buprenorphine

D: DPT (meperidine, promethazine and chlopromazine)

M: Meperidine

A: Agonist-Antagonists: pentazocine, butorphanol, nalbuphine

N: Naloxone

B: Barbituates

A: Anxiolytics alone: benzodiazepine

N: Naltrexone

D: DPT (meperidine, promethazine and chlorpromazine)

A: Avoid in CA

N: Nalbuphine

A: Avoid some opiods, ag-ant, partial ags, ants, combos, anxilytics alone, sedatives/hypnotics alone

CAMELBACK

C: Clonidine, Calcitonin

A: Anticonvulsants

(M: Methylphenydate)

E: Extra help for pain

L: Local anesthetics

B: Bisphosphonates

A: Antidepressents

(C: Corticosteroids)

(K: Ketamine)

Phase Non-Specific: CN PANDA

C: Cis-platin

N: Non-specifics

(Think Cycle Non-specific..he he)

P: Procarbazine

A: Alkylating agents

N: Nitrosurea

D: Dacarbazine

A: Anti-tumor Antibiotics

S specific: Cytosine arabinose, hydroxyurea (inhibit ribonucleotide reductase)

S phase self-limiting: 6 mercaptopurine, methotraxate

M Phase: Vincristine (neurotoxic), Vinblastine, Paclitaxel (stabilizs microtubules)

My (mitosis) VIN (vin crist and blast) TAX (paclitaxel)

"Cl ones": all have CL chloro-ethyl group attached

Nitrogen mustards (1st chemo tx): meChLoroethamine HL,

Melphalan (L-phenylalanine, L-PAM)

ChLorambucil,

cyCLophosphamide (Ifosfamide)

Nitrosureas:

Carmustine

Lomustine

Others: Cisplatin (Nephrotoxicity, peripheral neurop) Carboplatin, Busulfan, Davarbazine (DTIC), Procarbazien, Triethylene-thiophosphoramide (THIOTEPA)

CARBB

C: Carcinogenic

A: Alkylating Agents

R: toxic to Rapidly dividing cells

B: Bifunctionality (covalent cross-linkes from anti-tumor alkylating agent w/one cross link inhibiting progress of DNA repliaction)

B: bind nucelophilic group on cell and NT