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Hematology
Peripheral Vascular Disease
77
Biology
Undergraduate 2
02/29/2008

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Term

Peripheral Vascular Disease

 

Definition

Peripheral Vascular Disease

  1. •Problems related to arteries, veins, capillaries and lymph vessels-distal to heart
  2. •Chronic Problems
    1. –Associated with other diseases
Term
Arteries
Definition

Arteries

  • •Consist of 3 Layers
    1. –Intima-smooth inner layer
    2. –Media-muscular medial layer
    3. –Adventitia-fibrous outer layer
  • •Must be patent
  • •Must be able to constrict and dilate
Term

Arterial Disorders/Problems

Definition

Etiology

Atherosclerosis

Arterial spasms

Structural defects

Trauma

Blood clots

Failure of Artery= IschemiaTissue necrosis and death

Term
Veins
Definition

Same layers as arteries, but with minimal muscular layer

Can stretch more than arteries

Depend on valves and skeletal muscle surrounding them to move blood back to the heart

Must be patent, have valves that function, and muscles around them that work!

Term
Hypertension
Definition
  • Artery-Capillaries-VeinsHypertension
  • 11
  • Hypertension
  • •Dx as: Persistent high blood pressure
  • •Almost 60 million people in the United States have elevated blood pressure
  • •Occurs primarily in people between 25 to 55 years
  • •Responsible for over 30,000 deaths each year
  • •Called the "silent killer"-lack of specific symptoms
Term

Hypertension

Factors to Determine

Definition
  • Two factors determine blood pressure
    • –Cardiac output
    • •The volume of blood pumped by the heart
    • –Peripheral vascular resistance
    • •Force in the blood vessels that the left ventricle must overcome to eject blood from the heart
    • –Hypertension
    • –Diameter of the blood vessels
    • –Blood viscosity
Term

Hypertension

Classification

Definition
  • •Classification of B/P
    • –Diastolic
    • •90 -99 –mild
    • •100 -109 –moderate
    • •110 –119-severe
    • •> 120-hypertensive crisis
    • –Systolic pressure >140
    • •Pressure exerted during ventricular contraction (CO)
    • –Diastolic pressure
    • •Pressure during ventricular relaxation (PVR)
Term

Hypertension

Diagnosis

Definition
  • Diagnosis
    • –Based on 3 or more B/P readings
  • •Often the first symptoms are secondary disease complications
    • –MI
    • •Increased workload combined with decreased blood flow to the coronary arteries
    • –CAD
    • –Angina
    • –CHF
    • –Peripheral atherosclerosis
Term

Hypertension

Secondary Disease Complications

Renal

Definition
  • Secondary Disease-Complications
  • Renal
  • Glomerulus deprived of blood supply
  • Renal Failure
  • Stroke
  • Cerebral hemorrhage
  • Decreased blood flow and oxygen supply
  • Weakened vessel walls
Term

Hypertension

Secondary Disease Complications

Retinal

Definition
  • •Secondary Disease-Complications
    • –Retinal complications
    • •Narrowing of retinal arteries
    • •Retinal hemorrhages
    • •Papilledema
    • –Edema of the optic nerve
    • •Blindness
    • –CAD and MI
    • –Aneurysms
Term

Prolonged Hypertension

Definition
  • •With prolonged hypertension
    • –Elastic tissue in the arterioles is replaced with fibrous collagen tissue
    • –Thickened arteriole & decreased distensible
    • –Increased resistance to blood flow
    • –Which increases the blood pressure
Term
Hypertension Manifestations
Definition
  • •Manifestations
    • NON SPECIFIC-(Screening important)
    • –Fatigue
    • –AM HA (occipital)
    • –Blurred vision
    • –Epistaxis
    • –Lightheadedness
    • –Dizziness
    • –Palpitations
Term
Hypertension Types
Definition
  • •Essential/Primary Hypertension
    • –Etiology
    • •Unknown
    • OR
      • •Multifactorial
      • –Smoking
      • –Diet
      • –Chronic stress
Term

Hypertension

Secondary Hypertension

Caused by other disease process

Definition
  • Secondary Hypertension
    • –Caused by other disease process
    • •Chronic nephritis
    • •Diabetic nephropathy
    • •Hyperthyroidism
    • •PIH
    • •Alcohol
    • •Drugs
Term
Modifiable Risk Factors
Definition
  • 21Modifiable Risk Factors
  • •Obesity
  • •Smoking
  • •Diet -sodium, cholesterol
  • •Alcohol
  • •Stress
  • •Activity level
  • •Blood glucose level
Term
Non-Modifiable Risk Factors
Definition
  • •Age
  • •Sex (males)
  • •Race (African-American)Family history
    • –2x as high for individuals with family history
  • •Diabetes Mellitus
Term
Hypertension treatment
Definition
  • •Nonpharmacologic
    • –Weight reduction
    • –Diet
    • –Low sodium, low cholesterol, high potassium diet
    • –Smoking cessation
    • –Restrict alcohol and caffeine
    • –Relaxation techniques
    • –Monitor B/P -same time every day
    • –Exercise
Term

Hypertension Treatment

what we would like to use

Definition
  • Well-if we had the "Ideal drug"
    • –No long term toxic or unpleasant side effects
    • –Once daily medication
    • –Would not require complex dosing formulas & trial periods-works great right away
    • –Reduce the number of hypertension related serious illnesses & death
    • –Moderately priced
Term

Hypertension Treatment

What we Really Use

Definition
  • Instead we use Trial and Error
  • •Pharmacologic Agents
    • –Diuretics
    • –Beta Blockers
    • –Vasodilators-Apressoline
    • –ACE inhibitors-Capoten, Vasotec, Zestril
    • –Calcium Channel Blockers
    • –Alpha blockers-Minipress
    • –Sympatholytics-Catapress
Term
Hypertension Nursing
Definition
  • Ht & Wt
    • –Fluid retention
  • Edema
  • B/P assessment
    • –Both arms
    • –Supine, sitting, standing
    • –Appropriate size cuff
Term
Hypertension Teaching
Definition

•Disease process

•Diet –dietician

•Exercise program

•How to take B/P and pulse

  1. •Medications
    1. –How to take
    2. –Action
    3. –S/E
    4. –Take at the same time every day
    5. –Change positions slowly
    6. •Orthostatic hypotension

 

Term

Hypertension Teaching

Diuretics

Definition
  • Diuretics
    • –Avoid night time dose
    • –High potassium foods
    • •Unless it is K+ sparing (Aldactone)
    • –Cautious use of cold & sinus medications
    • –Know SE
    • •Hypovolemia
    • •Hypokalemia
    • •Hyponatremia
    • •Hypomagnesium
    • •Hypotension
Term

Hypertension Medications

Ace Inhibitors

Definition
  • Ace Inhibitors
  • •Action
    • –Inhibits conversion of Angiotensin I to Angiotensin II
    • –Decreases the secretion of Aldosterone
    • –Reduces peripheral vascular resistance
    • –S/E
    • •Hypotension
    • •Proteinuria (renal damage)
    • •Chronic cough
    • •Dizziness
    • •HA
    • •Fatigue
Term

Venous Disorders/Problems

Etiology

Definition
  • Venous Disorders/Problems
  • •Etiology
    • –Valve defects
    • –Thrombi
    • –Thrombophlebitis-DVT
  • •Failure of valve= blood pooling in the periphery which allows accumulation of media for bacterial growth.
  • •Eventually this leads to stasis ulcers
Term

Venous Disorders/Problems

Focused Assessment - Objective

NV Assessment

Definition
  • •NV assessment
    • Color
    • Pallor
    • •Cyanosis
    • Temp
    • •Cool
    • •Warm
    • Pulses
    • •Compare bilaterally
    • •Strong/diminished
    • •Palpable/ Doppler
    • Edema
    • •Amount
    • •Location
    • •Pitting
    • Sensation
    • •Sharp/dull
    • •Cool/ warm
    • •Paresthesia
    • •Pain
    • Movement
    • •Passive/active
Term

Focused Assessment Objective

Varicose Veins

Cellulitis

Definition
  • •Varicose veins
    • –Deep or superficial
  • •Cellulitis
  • •Trophic Changes
    • –Thickened nail beds
    • –Appearance of skin
    • –Hair growth (sparse)
    • –Skin Color
    • •Rubor-red/brown (arterial)
    • •Brown-venous stasis (venous)
  • •Bruits
  • •Lesions or Stasis ulcers
Term

Focused Assessment - Subjective

 

Definition
  • •Homan’s sign
    • –+ may be DVT -but unreliable
    • –Rarely done in practice
  • •Leg cramps/ aching calves
  • •Numbness/ tingling at rest
  • •Intermittent Claudication
    • –May indicate arterial occlusion
    • –=Pain of perfusion
    • –=pain with activity and pain with rest
  • •aresthesia
    • –Altered sensation
    • –"Gone to sleep"
Term

Focused Assessment - Subjective

Pain

Definition
  • •Pain
    • –Sharp/throbbing
    • –Tenderness
    • –Fullness
    • –Heavy
    • –Continuous/Intermittent
    • –What starts it
    • –What relieves it
Term

Focused Assessment - Subjective

History

Definition
  • •History
    • –Nicotine and Etoh use
    • •Constricts
    • –Diabetes
    • •Microcirculation damage
    • –HTN
    • •Damage to vessels
    • –Thrombophlebitis
    • •Immobility
Term
Arterial    Venous
Definition

 

Arterial

Venous

Absence of hair

Small painful ulcerations –lateral malleolus

Thick, shiny skin

Thick toenails

Brown skin

Broad shallow ulcers –medial malleolus

Varicosities

Eczema, stasis dermatitis

Nocturnal aching

Intermittent claudication

Cramping with elevation

Decreased sensation

Itching, thingling, numbness

Legs elevated –decreases pain

"Heavy" legs –end of day

Pruritus

Job history –standing, multiple pregnancies

Term
Diagnostic Tests
Definition
Term
Doppler Ultrasonography
Definition
  • Doppler Ultrasonography
  • •Measures amount of blood flowing through a vessel by use of soundwaves
  • •No preparation
  • •Non invasive
Term
Venogram
Definition
  • Venogram
  • •Injection of radioactive dye followed by x-rays reveals size and location of blood clot
Term
Angiogram
Definition
  • Angiogram
  • •Injection of radioactive dye into artery followed by x-rays to determine circulation
  • •Extensive post-procedure care
    • –Frequent vitals
    • –Assess bleeding at site
    • –Neuro-vascular checks distal to injection site
    • –Monitor for emboli/pressure dressing
    • –Keep leg immobile
Term
Lung/Nuclear Scan
Definition

Lung/Nuclear Scan

Diagnostic of pulmonary emboli

Compares pulmonary circulation with pulmonary ventilationRadiographic isotope injected and “tracked” by geiger counter–At the same time isotope is inhaled and tracked as well to determine if areas of the lung are being ventilated

Rapidly being replaced by pulmonary angiography

Term

Arterial

Aneurysms (Aortic)

Definition

Arterial Aneurysms (Aortic)

Medial layer of artery weakens and causes other layers to bulge

Pulsation pressure and blood pressure enlarge the defect

Especially dangerous in patients with HTN

Term

Aneurysms

Etiology

Definition
  • Etiology
    • –Congenital
    • –Hypertension
    • –Atherosclerotic plaque
  • •Types
    • –Fusiform
    • •Tubular swelling of arterial wall
    • –Saccular
    • •Weak area on one side of artery
    • –Dissecting
    • •Blood is pushed between artery wall layers causing separation & necrosis
Term

Aneurysms

Common Locations

Definition

Aneurysms

Common locations

Thoracic Aorta

Abdominal Aorta

Cerebral

Circle of Willis

Term

Aneurysms

S/S

Definition
  • Aneurysms
  • •S/S-depends on location
    • –Pulsating mass
    • –Bruit
    • –Visual changes
    • –Frequent headaches
    • –Mostly silent until rupture
Term

Aneurysm - RUPTURE!!

Definition
  • Aneurysm-RUPTURE!!
  • •MEDICAL EMERGENCY
  • •Excessive blood loss leads to shockand rapidly progresses to death
  • •Immediate medical intervention is the patient’s only hope of survival
Term

Aneurysm - RUPTURE

S/S

Definition
  • Aneurysm-RUPTURE!!
  • S/S
  • Sharp pain
  • Chest pain
  • Dyspnea
  • Intense headache
  • Visual changes
  • Photophobia
  • Extreme rise in BP
Term

Aneurysms

Diagnosis

Treatment

Definition

Aneurysms

•Diagnosis

–X-ray

–US

–Chest/ Abdominal CT

–Angiogram

•Treatment

–Graft replacement

•Triple A

•Organs distal cut off from blood flow

–Coil embolization or "coiling"

–Clipping

•Prevention

–Antihypertensives

Term

Aneurysms

Nursing

Definition

Aneurysms

•Nursing management

–Monitor vitals

•Shock

–Pulses

•Distal

–Tissue perfusion

–Pain meds

DO NOT PALPATE A PULSATING MASS!!!

Term
Arteriosclerosis
Definition

Arteriosclerosis

•Thickening, loss of elasticity or plaque formation in the intima or medial layers of the artery

•Obstructs blood flow

•Etiology-Unknown

–Hypertesion

–Aging

–Hyperlipidemia

–Diabetes

Term

Arteriosclerosis

Risk Factors

Definition

Arteriosclerosis

•Risk Factors

–Age

–Sedentary

–Family hx

–Uncontrolled HTN

–Poor diet

•Elevated lipids

–Chol and triglycerides

–Smoking

–Diabetes Mellitus

Term

Arteriosclerosis

Symtoms

Definition

Arteriosclerosis

•Symtoms

–Claudication (intermittent)

–Pain at rest

•Burning

•Decreases with dangling

–Distal to occlusion

•Coolness

•Color-mottled

•Decreased pulses to absent-COMPARE

•Ulceration/ gangrene

Term

Arteriosclerosis

Treatment

Definition

Arteriosclerosis

•Treatment

–Stop smoking

–Diet

•Decrease sat fat and chol

–Control HTN

–Vasodilators   Blood pressure

–Surgery

•Graft by-pass

•Endarterectomy

•Amputation of extremity

–Multiple nursing concerns

Term

Buerger-Allen exercises

Definition

Buerger-Allen exercises

•Increases peripheral blood circulation

–Lay supine

–Elevate legs above heart for 2 min or until blanched

–Lower legs and flex and extend feet for three min until pink

–Lay flat for 5 min

–Repeat X6 TID or QID

Term
Raynaud's Disease
Definition

Raynaud’s Disease

•Abnormal vasoconstriction of extremities (especially the hands)

•Primarily effects females 18-40 y/o

•S/S-r/t exposure to cold or emotional distress

•Hx of symptoms for 2 years to properly diagnose

Term

Raynaud's Disease

S/S

Definition

Raynaud’s Disease

•S/S

–Chronic cold hands and feet

–Attacks of pallor to cyanosis to digits

–Numbness and pain

–Followed by

•Intense redness

•Tingling

•Throbbing (reactive hyperemia

Term

Raynaud’s Disease

Treatment

 

Definition

Raynaud’s Disease

•Treatment

–Keep warm

–Decrease stress

–Stop smoking

–Vasodilators

–Ca++ channel blockers

•Cardizem, Verapamil, Procardia

–Extreme cases

•Amputation or Sympathectomy

Term

Arterial Embolism

Definition

Arterial Embolism

•Sudden occlusion of an artery by a foreign substance or blood clot

•Cuts off blood flow

–#1-blood clot

–Air

–Fat

–Catheter

Term

Arterial Embolism

S/S

 

Definition

Arterial Embolism

•S/S

–Sudden onset of pain

•Coldness

•Numbness

–Burning or aching in extremities

–Decreased or absent pulses

–Pallor or cyanosis

–Sharp line of color and temp demarcation

Term

Arterial Embolism

Treatment

 

Definition

Arterial Embolism

•Treatment

–Bedrest

–Anticoagulants

–Thrombolytics

–Treat shock if necessary

–Embolectomy

–Chronic

•Vena cava umbrella (filter)

Term

Pulmonary Embolus

Definition

Pulmonary Embolus

•Obstruction of the pulmonary artery or its branches

•Etiology

–Sudden onset

–Usually caused by embolus from thrombus in lower extremity (DVT)

Term

Pulmonary Emboli

•S/S -primary

Definition

Pulmonary Emboli

•S/S -primary

–Sharp chest pain

–Dyspnea

–Cyanosis

–Confusion

–Hemoptysis

–Fever

–Tachycardia

Term

Pulmonary Emboli

Diagnostics

Definition

Pulmonary Emboli

•Diagnostics

–Pulmonary angiogram

–VQ scan

–EKG

–ABG

Term

Pulmonary Embolus

Treatment

 

Definition

Pulmonary Embolus

•Treatment

Notify the Physician!!!

–Thrombolytics

•TPA-Tissue plasminogen Activator

•Streptokinase

•Urokinase)

–Emergency Surgery

•Embolectomy

•Vena Caval filter

Blood flow must be restored

Term

Pulmonary Embolus

Nursing Care

Definition

Pulmonary Embolus

•Nursing Care

–Stay calm (you AND the patient)

–Prevention

•TEDs

–Off 20 min twice a day

•SCDs

•Leg exercises

•Hydration

•Don’t place things behind knees

Support respiratory function

Elevate HOB

O2/ Ventilate if needed

ABG’s

BEDREST

Term

Thrombolytics

Definition

Thrombolytics

•Actually dissolves blood clots involving

–Coronary artery thrombi

–Deep vein thrombi

–Pulmonary embolism

–Cerebral artery thrombi

•Binds to fibrin

–Converts plasminogen to plasmin and degrades fibrin

Term

Thrombolytics

Uses

Definition

Thrombolytics

•Used with risk to major organs

–Heart

–Lung

–Kidney

–Brain

•High Risk for Bleeding

–Dissolves ALL clots

–Hemorrhagic CVA

–Intracranial Bleed

•HA

•N/V

•Confusion

Term

Varicose Veins

Pathophysiology

Definition

Varicose Veins

•Pathophysiology

–Enlarged veins

–Engorged with blood

–Incompetent Valves

–Vessel wall weakness

Term

Varicose Veins

Etiology

Definition

Varicose Veins

•Etiology: 40-60 y/o female

–Congenital absence of valves

–Increased pressure

•pregnancy/ tumor/ ascites

–Prolonged standing

–Constrictive clothing

–Obesity

•Deep varicose veins create venous stasis resulting in venous insuffiency

Term

Varicose Veins

S/S

Definition

Varicose Veins

•S/S

–Darkened swollen veins

–Heavy feeling in legs

–Pain/fatigue

–Muscle cramps

–Edema

–Brown discoloration of skin

Term

Varicose Veins

Dx

Definition

Varicose Veins

•Dx

–Venogram

–Doppler US

–Brodie Trendelenburg method

Term

Varicose Veins

Brodie

Definition

Varicose Veins

•Brodie-Trendelenburg Method

–Lie flat and elevate the affected leg to empty blood from vessels

–Apply soft tourniquet to upper thigh to restrict venous filling

–Stand and walk around then release tourniquet

–Compare before and after

Term

Varicose veins

Treatment

Definition

Varicose Veins

•Treatment

–Elevate legs whenever possible at least q 2-3 hours

–Elastic stockings-support vessels

–Lose weight

–Elevate legs when sitting

–Exercise

Term

Varicose Veins

Treatments

 

Definition

Varicose Veins

•Treatments

–Vein ligation/stripping

•Saphenous vein is tied at femoral junction

•Vein is stripped/ligated from ankle to groin

–Sclerotherapy

•Inject superficial veins with a sclerosing solution (hypertonic saline)

•Permanent obliteration

Term

Thrombophlebitis

Etiology

Definition

Thrombophlebitis

•Inflammation of vein accompanied by a clot

•Etiology (Virchow’s Triad)

–Venous stasis

–Damage to vessel wall

–Blood hypercoaguability

–R/T

•Major surgery

•Immobility

•MI

•BCP

•Pregnancy

•IV’s

•Dehydration

Term

Thrombophlebitis

S/S

Definition

Thrombophlebitis

•S/S

–Positive Homans’ sign

–Skin over vein

•Reddened

•Swollen

•Warm

•Tender

Term

Thrombophlebitis

Treatment

Prevention

Definition

Thrombophlebitis

•Treatment

–Bedrest-do nothing that could break the clot loose

–No massage

–Warm, moist soaks-WMS

–Anticoagulants

–Elevate leg without pressure under the knee

•Prevention

–TEDS/ SCD’s

–Hydration

–DO NOT PUT PILLOWS BEHIND KNEE

Term

Anticoagulants

 

Definition

Anticoagulants

•Heparin

–Inactivates thrombin

–IV or SQ-Never IM

–Elevates PTT

–Antidote-protamine sulfate

–SQ-abd no aspiration or massage

–Decrease platelet response

 

•Coumadin

–Works on prothrombin

–PO

–Elevates PT/INR

–Antidote-Vit K

–Slow build up in blood

Term

Anticoagulants

Side Effects

Contraindications

Definition

Anticoagulants

Side Effects

–Bleeding/ hemorrhage

–Occult bleeding (stool or urine)

–Bruising

–Gums bleeding

–Back pain

–Petechiae

 

Contraindications

–Anyone with history of bleeding probs

–Ulcers

–Recent surgery (can be done but very cautiously

Term

Surgical Techniques with PVD

Sympathectomy

Thrombectomy/Embolectomy

Definition

Surgical Techniques with PVD

•Sympathectomy

–Excision of a portion of the sympathetic division of the ANS which supplies peripheral vessels

–Relieves vasoconstriction

•Thrombectomy/Embolectomy

–Open vessel and remove clot

–High risk for CVA

–Frequent neuro checks

Term

Surgical Techniques with PVD

Graft Replacement

 

Definition

Surgical Techniques with PVD

•Graft Replacement

–Excision of aneurysm

–Removed tissue replaced with graft

•fem-popfem-femaorta-fem

•Endarterectomy

–Removal of artery lining (intima) from occluded vessel

–Carotid/Femoral/ Popliteal

•Assess distal to surgical areas

Term

Surgical Techniques With PVD

Amputation

Definition

Surgical Techniques with PVD

•Amputation

–Removal of limb

–Preop

•prepare psychologically

–Post-op

•High risk for bleeding

•Elevate limb for 24 hours or more to decrease bleeding and swelling

•Maintain extension to decrease contractures

•Monitor VS-shock

•Monitor dressing and stump

 

–Nursing Considerations

•After stump shrinks may have prothesis

•Phantom limb pain

•PT/Rehab

Term
Implementation and teaching for PVD
Definition

Implementation and Teaching for PVD

•Keep warm

•No restrict. clothing

•Elevate Legs

•TED’s SCD’s

•Progressive Exercise

•Buerger Allen exercises

•Avoid nicotine

 

•Protect from injury

•Keep linen off feet

•Daily foot assessment

•Encourage fluids

•Weight management

•Foot care by Dr.

•Proper fitting shoes

•White socks

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