Term
Match the tests to features:
Reduced in DIC |
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Definition
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Term
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Elevated during Heparin Therapy |
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Definition
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Term
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Test for Factor XIII |
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Definition
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Term
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Normal is about 170-400 mg/dL |
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Definition
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Term
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Measures substance in mg/dL |
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Definition
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Term
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Latex agglutination slide test |
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Definition
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Term
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Prolonged if Factor I is deficient |
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Definition
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Term
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Elevated in inflammation or third trimester of pregnancy |
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Definition
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Term
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Often DECREASED during a difficult labor or delivery |
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Definition
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Term
Match the tests to features:
Normal is about 20 seconds |
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Definition
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Term
| A 50:50 mix of PATIENT PLASMA & NORMAL PLASMA NOT Correcting an elevated PTT is a screening test for __________. |
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Definition
Circulating anticoagulants/ Inhibitors/
Lupus anticoagulants |
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Term
| What prevents the d-dimer or FDP test from detecting fibrinolysis which may occur after the blood is drawn? |
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Definition
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Term
| Explain how FDP Assay differs from D-dimer |
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Definition
The D-dimer test detests FSPs only from cross-linked fibrin and NOT from fibrinogenolysis.
The FSP test is POSITIVE in DIC & Primary fibrinogenolysis, whereas the D-Dimer is ONLY POSITIVE when there was clotting, such as in DIC or Thrombosis. |
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Term
All of the following are seen in DIC EXCEPT:
A. Prolonged PT, APTT, & TT
B. Decreased Platelet Function
C. Decreased FDP or D-Dimer |
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Definition
| C. Decreased FDP or D-Dimer |
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Term
| Chemotherapy drugs such as methothrexate have what affect on the platelet count? |
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Definition
| LOWERS the platelet count by INHIBITING Cell PRODUCTION |
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Term
A patient has an ELEVATED PTT which CORRECTS with Absorbed PLASMA but NOT Aged SERUM.
Which factor is suspected? |
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Definition
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Term
A patient has an ELEVATED PTT which CORRECTS with Absorbed PLASMA but NOT Aged SERUM.
What is the name of the disease/disorder? |
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Definition
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Term
A patient has an ELEVATED PTT which CORRECTS with Absorbed PLASMA but NOT Aged SERUM.
What test would confirm the initial suspicion? |
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Definition
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Term
A patient has an ELEVATED PTT which CORRECTS with Absorbed PLASMA but NOT Aged SERUM.
How could this condition be distinguished from vonWillibrand's? |
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Definition
| Bleeding Time or Platelet Aggregation |
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Term
| A patient who is Deficient in Protein C or S or ATIII will be prone to __________. |
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Definition
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Term
| A previously healthy patient now with a blood clot has an ELEVATED PTT which corrects with BOTH Absorbed PLASMA AND Aged SERUM. Which Factor Deficiency is MOST Likely? |
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Definition
Factor XII deficiency results in clotting.
XI or XII BOTH give those mixing study results. However, XI deficiency results in bleeding, whereas XII in clotting. |
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Term
A patient has a Thrombin Time of 100 seconds and a reptilase time of 18 seconds. Which of the following is most likely?
A. Patient is on Heparin
B. INCREASED Fibrin Split Products
C. DECREASED Fibrinogen
D. Patient has DIC |
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Definition
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Term
| Why will a SHORT Draw on a BLUE top Prolong the PTT? |
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Definition
| Short draw produces less plasma & therefore less Calcium. Decreased Calcium means that NOT all of the Sodium Citrate gets bound. This EXCESS Citrate will bind to Calcium in the test system and Prolong the test. |
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Term
| Explain heparin induced thrombocytopenia. |
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Definition
| About 3% of patients on heparin will build an ABY to the Heparin/Platelet complex. This ABY causes the platelets to clump & causes the count to DECREASE RAPIDLY. All patients on heparin should have daily platelet counts. |
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Term
| What adjustment must be made to coagulation testing if a patient has a hematocrit of 65%? |
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Definition
| Sample must be recollected with less anticoagulant. |
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Term
| Why must an adjustment be made to coagulation testing if a patient has a hematocrit of 65%? |
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Definition
| When the HCT is INCREASED, there is LESS PLASMA, and therefore Less Calcium so not all the sodium citrate gets bound. This excess citrate will bind of Calcium in the test system and prolong the tests. |
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