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Hematology Internship Section 3
Coagulation Study Questions Part 2
27
Biology
Undergraduate 4
10/13/2015

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Term
Match the mixing study results with the following deficiencies if the PT is NORMAL and the PTT is INCREASED:

Corrects with absorbed PLASMA and NOT aged SERUM
Definition
Factor VIII Deficiency
Term
Match the mixing study results with the following deficiencies if the PT is NORMAL and the PTT is INCREASED:

Corrects with aged SERUM and NOT absorbed PLASMA
Definition
Factor IX Deficiency
Factor X Deficiency
Term
Match the mixing study results with the following deficiencies if the PT is NORMAL and the PTT is INCREASED:

Corrects with BOTH absorbed PLASMA AND aged SERUM
Definition
Factor XI Deficiency
Factor XII Deficiency
Term
Match the mixing study results with the following deficiencies if the PT is NORMAL and the PTT is INCREASED:

Corrects with 50:50 mix of PATIENT PLASMA and Normal Plasma
Definition
Factor VIII Deficiency
Factor IX Deficiency
Factor X Deficiency
Factor XI Deficiency
Factor XII Deficiency
Term
Match the mixing study results with the following deficiencies if the PT is NORMAL and the PTT is INCREASED:

Does NOT Correct with 50:50 Mix of PATIENT PLASMA and Normal Plasma
Definition
Lupus anticoagulant (antiphospholipid antibody)
Term
Match the following platelet elements to the correct disease or function:

Bernard Soulier
Definition
Glycoprotein Ib
Giant Platelets
Thrombocytopenia
Term
Match the following platelet elements to the correct disease or function:

Glanzmann Thrombasthenia
Definition
Glycoprotein IIb/IIIa
Term
Match the following platelet elements to the correct disease or function:

Platelet adhesion
Definition
Glycoprotein Ib
Term
Match the following platelet elements to the correct disease or function:

Platelet aggregation
Definition
Glycoprotein IIb/IIIa
Term
What are the two most common causes of bleeding?
Definition
Liver Disease
Thrombocytopenia
Term
Aspirin usage results in a flat line (no aggregation) with what agonists in platelet aggregometry?
Definition
ADP
Epinephrine
Collagen
Term
Which coagulation disorders have NORMAL PT & PTT?
Definition
Factor XIII Deficiency
Platelet Disorders
Term
Which protein is the major inhibitor of the fibrinolytic system?
Definition
Alpha-2-antiplasmin
Term
Match the following platelet disorders with the correct descriptions:

Immune destruction of platelets
Definition
Acute ITP
Chronic ITP
Term
Match the following platelet disorders with the correct descriptions:

Associate with renal failure and neurologic symptoms
Definition
TTP
Term
Match the following platelet disorders with the correct descriptions:

Associated with sepsis and obstetrical problems
Definition
DIC
Term
Match the following platelet disorders with the correct descriptions:

Prolonged PT, PTT
Definition
DIC
Term
Match the following platelet disorders with the correct descriptions:

Reduced platelet count
Definition
Acute ITP
Chronic ITP
TTP
DIC
Term
Match the following platelet disorders with the correct descriptions:

Normal PT & PTT
Definition
Acute ITP
Chronic ITP
TTP
Term
Which of the following would give a NORMAL bleeding time?
A. Patient with hemophilia A
B. After aspirin ingestion
C. Platelet count of 10,000 / microliter
D. Patient with vonWillibrand's
E. Patient with DIC
Definition
A. Patient with hemophilia A
Term
A patient with Glanzmann's Throbastehnia or other qualitative platelet disorder has a platet count of 300,000 / microliter. Which of the following tests will be abnormal?
A. Automated platelet count
B. Manual Platelet count
C. Platelet aggregation
D. PTT
Definition
C. Platelet aggregation
Term
Match the following platelet disorders with the correct descriptions:

Normal PT & PTT
Definition
Acute ITP
Chronic ITP
TTP
Term
Match the following platelet disorders with the correct descriptions:

Treat with Plasma Exchange
Definition
TTP
Term
Match the following platelet disorders with the correct descriptions:

Schistocytes
Definition
TTP
DIC
Term
Match the following platelet disorders with the correct descriptions:

POSITIVE D-Dimer
Definition
DIC
Term
Match the following platelet disorders with the correct descriptions:

Found mostly in children following an infection
Definition
Acute ITP
Term
Match the following platelet disorders with the correct descriptions:

Found in young women, VASTLY DECREASED Platelets, the rest of the CBC is NORMAL
Definition
Chronic ITP
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