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Hematology Internship Section 3
Coagulation/Hemostasis Coagulation Disorders. Page 102
22
Biology
Undergraduate 4
10/14/2015

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Term
Given the Etiology, List the Coagulation Disorder associated with it:

Toxic damage to endothelial cell allows platelets to come into contact with vWF causing platelet clumps
Definition
Thrombocytic Thrombocytopenic Purpura (TTP) & Hemolytic Uremic Syndrome (HUS)
Term
Given the Etiology, List the Coagulation Disorder associated with it:

Defective Glycoprotein 1b inhibits platelets adhesion to vWF
Definition
Bernard Soulier Disorder
Term
Given the Etiology, List the Coagulation Disorder associated with it:

Defective Glycoprotein IIb/IIIa inhibits platelet aggregation
Definition
Glanzmann's Thrombasthenia
Term
Given the Etiology, List the Coagulation Disorder associated with it:

Decreased Number of platelet dense granules
Definition
Wiskott-Aldrich Syndrome
Term
Is Thrombocytic Thrombocytopenic Purpura (TTP) typically seen in adults or children?
Definition
Adults, not usually associated with infection
Term
Is Hemolytic Uremic Syndrome (HUS) typically seen in adults or children?
Definition
Children after infection, especially E. Coli O157:H7
Term
Given the following Test Results, List the Coagulation Disorder often associated with it:

DECREASED Platelet Count; Schistocytes; Coagulation tests usually NORMAL or Slightly ABNORMAL; Evidence of intravascular hemolysis
Definition
Thrombocytic Thrombocytopenic Purpura (TTP) & Hemolytic Uremic Syndrome (HUS)
Term
True or False:

Bruising, bleeding, kidney damage, and neurologic symptoms are all associated with Thrombocytic Thrombocytopenic Purpura (TTP) & Hemolytic Uremic Syndrome (HUS).
Definition
True
Term
How would/should you treat Thrombocytic Thrombocytopenic Purpura (TTP) & Hemolytic Uremic Syndrome (HUS)?
Definition
Plasma Exchange Or FFP
Term
Given the Etiology, List the Coagulation Disorder associated with it:

Decreased ATP and ADP in Platelet
Definition
Storage Pool Disease
Term
Is the following Coagulation Disorder Acquired or Genetic:

Bernard Soulier Disorder
Definition
Genetic
Term
Is the following Coagulation Disorder Acquired or Genetic:

Glanzmann's Thrombasthenia
Definition
Genetic
Term
Is the following Coagulation Disorder Acquired or Genetic:

Wiskott-Aldrich Syndrome
Definition
Genetic
Term
Is the following Coagulation Disorder Acquired or Genetic:

Storage Pool Disease
Definition
Genetic
Term
Is the Platelet count and morphology Normal, Increased, or Decreased for Glanzmann's Thrombasthenia?
Definition
NORMAL
Term
True or False:
Bernard Soulier Disorder & Glanzmann's Thrombasthenia are Rare Conditions
Definition
True
Term
Given the test results, List the Coagulation Disorder:

DECREASED Platelet Count with GIANT PLATELETS
Definition
Bernard Soulier Disorder
Term
True or False:

Bernard Soulier Disorder has ABNORMAL PLT Aggregation with Ristocetin
Definition
True
Term
Which Coagulation Disorder does the following Clinical description associate with:

Bleeding due to thrombocytopenia
Definition
Bernard Soulier Disorder
Term
Given the Test Results, Which Coagulation Disorder is associated with it:

INCREASED Bleeding Time;
Definition
Glanzmann's Thrombasthenia
Term
True or False:
Platelets DON'T Aggregate with ANY agonists EXCEPT for Ristocetin
Definition
True
Term
Which Coagulation Disorder is the following Clinical Description associated with:

Clot Retraction Absent; Bleeding
Definition
Glanzmann's Thrombasthenia
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