Term
A patient has a RBC of 1.95 x 10^6 / microliter, RDW of 21%, and MCV of 121 fL.
Describe the RBC morphology that would be seen. |
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Definition
| Macrocytes varying in size |
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Term
A patient with hereditary spherocytosis has 150 cells with blue/green inclusions per 1000 cells with new methylene blue stain. The RBC is 3.25 x 10^6 / microliter and the hematocrit is 33%.
What RBC morphology would be expected? |
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Definition
| Spherocytes, Polychromasia, and Anisocytosis |
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Term
A patient with hereditary spherocytosis has 150 cells with blue/green inclusions per 1000 cells with new methylene blue stain. The RBC is 3.25 x 10^6 / microliter and the hematocrit is 33%.
Calculate the MCV |
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Definition
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Term
A patient with hereditary spherocytosis has 150 cells with blue/green inclusions per 1000 cells with new methylene blue stain. The RBC is 3.25 x 10^6 / microliter and the hematocrit is 33%.
Is this an expected MCV result for this patient? |
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Definition
| Patients with extreme polychromasia often have a slightly increased MCV, because retics are larger than normal cells. |
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Term
A patient with hereditary spherocytosis has 150 cells with blue/green inclusions per 1000 cells with new methylene blue stain. The RBC is 3.25 x 10^6 / microliter and the hematocrit is 33%.
What is the uncorrected retic value? |
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Definition
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Term
A patient with hereditary spherocytosis has 150 cells with blue/green inclusions per 1000 cells with new methylene blue stain. The RBC is 3.25 x 10^6 / microliter and the hematocrit is 33%.
Is this uncorrected retic value within the normal range? |
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Definition
No, it is not within the normal value.
It is ABOVE the normal value. |
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Term
| What is the formula to find the corrected retic? |
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Definition
| (Patient Hematocrit / 45) x Uncorrected Retic |
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Term
| What is the formula to find the absolute retic? |
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Definition
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Term
A patient with hereditary spherocytosis has 150 cells with blue/green inclusions per 1000 cells with new methylene blue stain. The RBC is 3.25 x 10^6 / microliter and the hematocrit is 33%.
What is the patient's absolute retic value? |
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Definition
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Term
A patient with hereditary spherocytosis has 150 cells with blue/green inclusions per 1000 cells with new methylene blue stain. The RBC is 3.25 x 10^6 / microliter and the hematocrit is 33%.
Is this retic results expected on this patient? |
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Definition
| Yes, people with hemolytic anemia have highly increased retic. |
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Term
| When the Hct is <25%, What should the Retic % be? |
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Definition
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Term
| When the Hct is >35%, What should the Retic % be? |
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Definition
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Term
A patient with hereditary spherocytosis has 150 cells with blue/green inclusions per 1000 cells with new methylene blue stain. The RBC is 3.25 x 10^6 / microliter and the hematocrit is 33%.
What test could be used to distinguish hereditary spherocytosis from AIHA? |
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Definition
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Term
A patient with hereditary spherocytosis has 150 cells with blue/green inclusions per 1000 cells with new methylene blue stain. The RBC is 3.25 x 10^6 / microliter and the hematocrit is 33%.
Describe what would be the expected osmotic fragility results for this patient. |
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Definition
Osmotic Fragility would be Increased.
Cells would start to lyse @ 0.70% and have complete hemolysis @ 0.55% |
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Term
A patient with hereditary spherocytosis has 150 cells with blue/green inclusions per 1000 cells with new methylene blue stain. The RBC is 3.25 x 10^6 / microliter and the hematocrit is 33%.
What does the reticulocyte count indicate? |
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Definition
| % of New cells entering blood. |
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Term
| What does a normal retic of 1% mean? |
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Definition
| It means that 1% of the RBCs are turned over daily. |
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Term
Which of the following is INCREASED in Intravascular Hemolysis but NOT in Extravascular Hemolysis:
A. Bilirubin
B. Reticulocyte
C. Urine Hemosiderin
D. RBC |
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Definition
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Term
| What is Hemoglobin H Disease? |
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Definition
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Term
| How is Hemoglobin H detected? |
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Definition
| Excess Beta chains form tetramers that can be detected by hemoglobin electrophoresis, precipitation with brilliant cresyl blue, or by the heat with denaturation. |
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Term
Match the RBC morphology with its associated condition:
AIHA |
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Definition
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Term
Match the RBC morphology with its associated condition:
Cold Auto Antibody |
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Definition
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Term
Match the RBC morphology with its associated condition:
Multiple Myeloma (MM) |
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Definition
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Term
Match the RBC morphology with its associated condition:
Myelofibrosis |
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Definition
|
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Term
Match the RBC morphology with its associated condition:
DIC |
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Definition
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Term
Match the RBC morphology with its associated condition:
Liver Disease or Hemoglobinopathies |
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Definition
|
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Term
Match the RBC morphology with its associated condition:
Artifact or Uremia |
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Definition
| Echinocytes (burr or crenated) |
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Term
| What would you expect RBC's to look like if the Hgb was 10.2 g/dL, MCV was 90 fL, MCH was 29.5 pg, and MCHC was 34%? |
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Definition
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Term
| Describe hemoglobin C crystals |
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Definition
| Dense oblong crystals in and around RBCs |
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Term
| If hemoglobin C Crystals are seen, is it most likely Hgb C trait or disease? |
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Definition
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Term
| A patient has malarial rings and crescent shaped gametocytes. Which species is most likely present? |
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Definition
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Term
| RBC indices: MCV = 95 fL, RDW = 25.4%. What morphology is expected? |
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Definition
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Term
| Which test is most useful to initially ascertain if a normochromic, normocytic anemia is hemolytic or hypoproliferative due to marrow failure or suppression? |
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Definition
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Term
| List 2 conditions which are macrocytic but not megaloblastic |
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Definition
Liver Disease
Myelodysplasia
Reticulocytosis |
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Term
Which of the following is DECREASED in Intravascular Hemolysis:
A. Bilirubin
B. Plasma hemoglobin
C. Urine urobilinogen
D. Haptoglobin |
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Definition
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Term
| List 2 Disorders which have INCREASED Iron Stores |
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Definition
Hemochromatosis
Thalassemia
Massive Transfusions
Chronic Disease
Accidental Iron overdose in Children |
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Term
Match the RBC Inclusions with their composition or condition:
Composed of Iron |
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Definition
| Pappenheimer or siderocytes |
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Term
Match the RBC Inclusions with their composition or condition:
DNA |
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Definition
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Term
Match the RBC Inclusions with their composition or condition:
Precipitated Hemoglobin |
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Definition
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Term
Match the RBC Inclusions with their composition or condition:
Need supravital stain to see |
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Definition
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Term
Match the RBC Inclusions with their composition or condition:
Seen in post splenectomy patients |
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Definition
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Term
Match the RBC Inclusions with their composition or condition:
RNA |
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Definition
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Term
Match the RBC Inclusions with their composition or condition:
G6PD Patients |
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Definition
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Term
Match the RBC Inclusions with their composition or condition:
Found in lead poisoning and thalassemia trait |
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Definition
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Term
Match the RBC Inclusions with their composition or condition:
Observed in porphyrias or sideroblastic anemia |
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Definition
| Pappenheimer or siderocytes |
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Term
Match the RBC Inclusions with their composition or condition:
Will stain with Prussian blue |
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Definition
| Pappenheimer or siderocytes |
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Term
Match the RBC Inclusions with their composition or condition:
Increased in iron overload or ineffective heme/iron metabolism |
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Definition
| Pappenheimer or siderocytes |
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Term
| Explain how an ESR is affected by cells which will not rouleaux well, such as Spherocytes or sickle cells. |
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Definition
Neither sickle cells or Spherocytes form rouleaux well.
Cells must rouleaux in order to fall and be evaluated by the ESR |
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Term
Match the following test methods with the testing conditions:
Testing babies for sickle disease |
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Definition
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Term
Match the following test methods with the testing conditions:
Screening Adults for genetic counseling |
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Definition
| Sickledex or other solubility test |
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Term
Match the following test methods with the testing conditions:
Testing units in the blood bank for the presence of Hgb S |
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Definition
| Sickledex or other solubility test |
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Term
Match the following test methods with the testing conditions:
Distinguish thalassemia trait from iron deficiency |
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Definition
|
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Term
Match the following test methods with the testing conditions:
Diagnosing Hgb C disease |
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Definition
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Term
Match the retic results with the conditions:
Untreated iron deficiency |
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Definition
|
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Term
Match the retic results with the conditions:
Hemolytic Anemia |
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Definition
|
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Term
Match the retic results with the conditions:
Bone Marrow Failure |
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Definition
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Term
Match the retic results with the conditions:
4 Hours After Acute Bleed |
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Definition
|
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Term
Match the retic results with the conditions:
3 Days After Acute Bleed |
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Definition
|
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Term
Match the retic results with the conditions:
Hereditary Spherocytosis |
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Definition
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