Term
| Defects in Factors can be due to (4) |
|
Definition
Decreased synthesis (Liver)
Production of abnormal molecules
Consumption
Inhibitors or ABYs |
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Term
| Clotting factor defects may be _____ or ____ |
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Definition
|
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Term
| Congenital defects may be ______ or ______ or _________ |
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Definition
Sex-linked
Autosomal dominant
Autosomal recessive |
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Term
| Plasma coagulation factors are cofactors or precursors of ____ ______ that circulate as inactive substances |
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Definition
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Term
T or F:
Clot formation is the result of activation and the subsequent cascade |
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Definition
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Term
| T or F: If one factor is missing, blood will NOT clot |
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Definition
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Term
| Fibrinogen is an ______-____ ______ |
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Definition
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Term
| T or F: Physiologic stress can cause an increase in the fibrinogen produced |
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Definition
|
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Term
| A large glycoprotein produced in the liver |
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Definition
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Term
| Normal fibrinogen levels are |
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Definition
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Term
| Factor I Deficiency APTT and PT are |
|
Definition
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Term
|
Definition
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Term
|
Definition
|
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Term
|
Definition
Qualitative disorder
Fibrinogen is not working properly |
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Term
| Factor I Deficiency treat with |
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Definition
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Term
|
Definition
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Term
| Cryo contain ____, ____, ____ |
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Definition
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|
Term
| Fibrinogen problems are usually _____ rather than ______ |
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Definition
|
|
Term
Synthesized in the liver
Most abundant of the vitamin-K dependent clotting proteins |
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Definition
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Term
| Factor II - _______ PT and APTT |
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Definition
|
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Term
| Deficiencies do not occur because it is found only in the tissue |
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Definition
| Factor III (Thromboplastin) |
|
|
Term
| If too low to clot, incompatible with life |
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Definition
|
|
Term
Acts as a cofactor in the activation of prothrombin
Produced in the liver |
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Definition
|
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Term
| Congenital factor V deficiency is also known as |
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Definition
|
|
Term
| Parahemophilia is an ____. ____-___ ____ |
|
Definition
| inherited, autosomal-recessive trait |
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Term
| T or F: Factor V Deficiency patients will have mild clinical disorders |
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Definition
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Term
| Factor V Deficiency - APTT and PT are _____ |
|
Definition
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Term
| Treat Factor V Deficiency with |
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Definition
|
|
Term
|
Definition
|
|
Term
Vitamin-K dependent factor
Produced in the liver
Treat with FFP |
|
Definition
| Factor VII (Proconvertin) |
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|
Term
| Factor VII (Proconvertin) is _____ as an ____ _____ deficiency |
|
Definition
Inherited
Autosomal recessive |
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|
Term
| Factor VII (Proconvertin)- ______ PT and _____ APTT |
|
Definition
|
|
Term
A large glycoprotein
Made in the liver
Not Vitamin K dependent
Factor is labile |
|
Definition
| Factor VIII (Anti-Hemophiliac) |
|
|
Term
T or F:
You will not find Factor VIII in serum |
|
Definition
True
It will be consumed in the clot |
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|
Term
| 2 portions of the Factor VIII molecule |
|
Definition
|
|
Term
| Coagulant and smaller portion of Factor VIII |
|
Definition
|
|
Term
| Necessary for Plt adhesion to collagen |
|
Definition
|
|
Term
| Attaches collagen to glycoprotein IB on Plt surface |
|
Definition
|
|
Term
| Two diseases associated with factor VIII deficiency |
|
Definition
Hemophilia A
Von Willebrand's disease |
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|
Term
| Factor VIII factor assay will be _____ in both Hemophilia A and Von Willebrand's disease |
|
Definition
|
|
Term
| Deficiency is the clotting portion only; smaller protein unti |
|
Definition
|
|
Term
| Deficiency is the clotting portion as well as platelet adhesion; larger protein unit |
|
Definition
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|
Term
| The most common hereditary coagulation disorder |
|
Definition
|
|
Term
T or F:
Hemophilia A is a sex-linked recessive bleeding disorder |
|
Definition
|
|
Term
How much of Factor VIII normal is found in the following:
Severe
Moderate
Mild
Carrier |
|
Definition
|
|
Term
Severe bleeding into joints
15% will develop ABYs to the VIII factor |
|
Definition
|
|
Term
Hemophilia A
_____ APTT
_____ PT
_____ Bleeding Time |
|
Definition
|
|
Term
T or F:
With hemophilia A, APTT will correct with absorbed plasma but not serum |
|
Definition
|
|
Term
| Treatment for Hemophilia A (3) |
|
Definition
Human VIII factor
Cryprecipitate obtained when thaw FFP at 1-6 degrees Celcius
Newer factor VIII concentrates are powdered |
|
|
Term
Autosomal inherited disorder
prolonged bleeding times
Mucocutaneous bleeding (dentist), bruising |
|
Definition
|
|
Term
Von Willebrand's Disease:
APTT will be ______
__ _ ___ VIII: vWF
FVIII:C activity will also be ______ |
|
Definition
Prolonged
Low or Absent
Abnormal |
|
|
Term
T or F:
Von Willebrand Disease - Factor is stable |
|
Definition
|
|
Term
| Treat Von Willbrand Disease with |
|
Definition
|
|
Term
T or F:
Von Willebrand Disease - Abnormal platelet aggregation with ristocetin |
|
Definition
|
|
Term
| Is Von Willebrand Disease Dominant or Recessive? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Factor IX: Present in ____ but not ___ ___ |
|
Definition
|
|
Term
| Factor IX is acquired in ___ ___ or ___ ___ |
|
Definition
Liver Disease
Coumadin Therapy |
|
|
Term
| IF Factor IX Deficiency is inherited it is referred to as |
|
Definition
|
|
Term
T or F:
Factor IX is a Vitamin K Dependent factor and is synthesized in the liver |
|
Definition
|
|
Term
|
Definition
FFP
Cryo
Prothrombin Complex |
|
|
Term
Factor IX
_____ APTT
_____ PT |
|
Definition
|
|
Term
| Factor IX will _____ with serum but not with ___ ____ |
|
Definition
|
|
Term
|
Definition
|
|
Term
Deficiency is rarely inherited
Vitamin K Dependent
Produced in the liver |
|
Definition
|
|
Term
| Most severely affected Factor X Deficient patients will have ___-____ ____ |
|
Definition
| post-operative hemorrhage |
|
|
Term
Factor X:
______ PT
______ APTT |
|
Definition
|
|
Term
| Plasma Thromboplastin Antecedent |
|
Definition
|
|
Term
| Inherited form is called Hemophilia C |
|
Definition
|
|
Term
| Hemophilia C is an ___ ___ trait |
|
Definition
|
|
Term
T or F:
Factor XI is one of the contact factor proteins involved in early coagulation and it is synthesized in the liver |
|
Definition
|
|
Term
Factor XI:
____ PT
____ APTT |
|
Definition
|
|
Term
|
Definition
|
|
Term
T or F:
Factor XII Disorder is NOT associated with clinical bleeding or hemorrhage |
|
Definition
|
|
Term
| Factor XII is _____ in an ___-___ fashion |
|
Definition
inherited
autosomal-recessive |
|
|
Term
| With Factor XII there is an increased incidence of _____ ____ |
|
Definition
|
|
Term
| Factor XII Deficient patients will be prone to having ___ ____ or _____ |
|
Definition
Myocardial infarction
thromboembolism |
|
|
Term
|
Definition
|
|
Term
T or F:
Is is difficult to monitor heparin in a patient with a Factor XII Deficiency |
|
Definition
|
|
Term
| Factor ____ is responsible for the formation of a stable fibrin clot |
|
Definition
|
|
Term
| Fibrin-Stabilizing Factor AKA |
|
Definition
|
|
Term
| The only enzyme in the coagulation system that is not a serine protease |
|
Definition
|
|
Term
| Factor XIII _____ with fibrinogen |
|
Definition
|
|
Term
With which factor deficiency does the following occur:
In homozygous cases, there is initial stoppage of bleeding followed by recurrence of bleeding 36 hours after the initial traumatic event |
|
Definition
| Factor XIII (Fibrin-Stabilizing Factor) |
|
|
Term
| Factor XIII deficiency - the bleeding is the result of the |
|
Definition
| dissolution of the fibrin clot that initially formed and was not stabilized by Factor XIII |
|
|
Term
Factor XIII:
____ APTT
____ PT
____ BT
____ Plt Count
____ fibrinogen |
|
Definition
|
|
Term
| Screening test for XIII is based on the ____ of a ____ ___ ___ in a 5-molar ___ ___ |
|
Definition
solubility
recalcified plasma clot
urea solution |
|
|
Term
| The screening test for Factor XIII deficiency is referred to as the |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| High-Molecular-Weight Kininogen |
|
|
Term
Prekallikrein:
May experience ___ ___
____ ____ of the APTT |
|
Definition
thrombotic events
Marked prolongation |
|
|
Term
HMWK:
May experience ___ ___ ___ and ___ ___
____ ____ APTT |
|
Definition
deep vein thrombosis
pulmonary embolus
Markedly prolonged |
|
|
