Term
Occurs weeks after viral infectio in children
IgG against platelet GpIIb/IIIa |
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Definition
Immune thrombocytopenic purpura
Tx: corticosteroids
IVIg
Spelectomy |
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Term
Normal PT/PTT
Dec platelet count
Inc megakaryocytes on bone marrow biopsy |
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Definition
Immune thrombocytopenic pupura
Tx: corticosteroids
IVIg
Spelectomy |
|
|
Term
Shistocytes
Decreased ADAMTS13
Thrombocytopenia
Normal PT/PTT |
|
Definition
Thrombotic thrombocytopenic pupura (TTP)
ADAMTS13 - normally cleaves vWF multimers into smaller monomers. Failure to do so leads to abormal platelet adhesion |
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Term
Anemia following bloody diarrhea (dysentery)
Thrombocytopenia
Normal PT/PTT
Anemia with schizocytes |
|
Definition
Hemolytic Uremic Syndrome (HUS)
From verotoxin of E. Coli O157:H7
Usually undercooked beef |
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Term
| Genetic GPIb deficiency, platelet adhesion impaired |
|
Definition
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Term
| Genetic GpIIb/IIIa deficiency, platelet aggregation impaired |
|
Definition
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|
Term
Deep tissue/joint bleeding
Elevated PTT; normal PT
Normal platelet and bleeding time
Inherited bleeding disorder |
|
Definition
Hemophilia A and B
Decreased factor VIII or factor IX |
|
|
Term
Increased bleeding time
Increased PTT; normal PT
Abnormal ristocetin test |
|
Definition
Von Willebrand Disease - deficiency in Von willebrand factor
Ristocetin test - chemical that induces platelet aggregation by having vWF bind to GpIb
Tx: Desmopressin (DDVAP) |
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|
Term
Decrease in Factors II, VII, IX, X, Protein C and Protein S
Commonly seen in newborns or malabsorption |
|
Definition
Vitamin K deficiency
Tx: Vitamin K, Fresh frozen plasma |
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|
Term
| Drug that activates antithrombin III causes platelet destruction |
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Definition
| Heparin Induced thrombocytopenia (HIT) |
|
|
Term
decreased platelet count
Increased PT/PTT
Decreased fibrinogen
Microangiopathic hemolytic anemia
Elevated D-dimer |
|
Definition
| Disseminated intravascular coagulation (DIC) |
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|
Term
Hypercoagulable state
Defect in cleavage site on factor V |
|
Definition
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|
Term
Hypercoagulable state
Increased gene expression of prothrombin |
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Definition
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|
Term
Hypercoagulable state
PTT does not rise with standard heparin dosing |
|
Definition
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|
Term
Hypercoagulable state
increased risk for warfarin skin necrosis (because warfarin acts on these factors first) |
|
Definition
| Protein C or S deficiency |
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