Term
antigen antibody reaction to transfusion of ABO incompatible blood |
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Definition
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Term
symptoms of hemolytic reaciotn |
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Definition
fever, chills, nausea, dyspnea, chest pain, back pain, hypotension, hematuria |
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Term
treatment of hemolytic reaction |
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Definition
stop the transfusion notify the physician immediatel be prepared to provide supportive therapy to maiantin heart rate and bp |
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Term
type 1 hypersensitivity reaction to plasma proteins |
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Definition
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Term
symptoms of anaphylactic reaction |
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Definition
urticaria, wheezing, dyspnea, hypotension |
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Term
anaphylactic reacion occurs within _ of starting infusion |
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Definition
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Term
treatment for anaphylactic reation |
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Definition
stop the transfusion notify the physician immediately be prepared to administer epinephrine and steroids |
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Term
recipent's antibodies react to dono leukocytes |
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Definition
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Term
symptoms of febrile reactions |
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Definition
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Term
rebrile reaction occurs within _ of starting transfusion |
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Definition
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Term
treatment for febril reaction |
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Definition
stop the transfusion notify the physician |
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Term
patent's cardiovascular sytem is unable to manage the additional fluid load |
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Definition
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Term
symptoms of ciculatory overload |
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Definition
cough, frothy sputum, cyanosis, decreased blood pressure |
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Term
treatment for circulatory overload |
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Definition
stop the transfusion call for help be preapred to administer oxyghen and/or furosemid |
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Term
reaction occurs in patients previousl treated with red blood cell tranfusions and alloimmunized so that patient's own immune system attacks transfused RBCs |
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Definition
delyaed hemolytic reaction |
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Term
symptoms of delayed hemolytic reactions |
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Definition
unexplained fever, unecplained decrease in hemoglobin an dhematocrit |
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Term
delayed hemolytic reaction occures _ after transfusion |
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Definition
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Term
erythropoietic growht factors |
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Definition
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Term
stimulates bone marrow to produce red blood cells |
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Definition
erythropoietic growth factors |
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Term
sied effects of erythropoietic growth factors |
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Definition
hypertension, headache, arthralgia, risk of cardiac arrest, heart failure, stroke and MI, especially if given wwhen hgb approaches 11 g/dL or when hgb rises to rapidly |
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Term
nursing interventions for erythropietic growth factors |
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Definition
usually adminsitered subq, can be given iv, treated 3 times a week with apoetin alfa or once weekly with darbapoetin alfa until the hct is 30-33 |
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Term
thrombopoieitc growht factor |
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Definition
oprelvekin, romiplostim, eltrombopag, plerixafor, leukopoietic growth factors |
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Term
stimulates bone marrow to produce plateltes |
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Definition
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Term
used to minimize patelt deficiency in patients on certain chemotherapy drugs |
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Definition
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Term
side effects of oprelveki (neurmega) |
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Definition
retention of water and sodium, dysrhthmias, sever allergic reaction, visual disturbances, dizziness, insomina, dyspnea, oral candidiasis |
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Term
oprelvekin is given by suba injection once a day fro up to _ |
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Definition
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Term
observe for signs of allergic reaction when taking oprelvekin which are |
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Definition
rash, urticarial, flushing, fever, hypotension, chest pain, wheezing, dyspnea, edema of the face and tongue |
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Term
increase platelet prduction in patients with idopathic thrombocytopenic purpura |
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Definition
romiplostim (nplate) eltrombopag (promacta) |
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Term
side effects of romiplostim and eltrombopag |
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Definition
althralgia, dizziness, insomina, pain in abdomen, shoulders and extremities uncommon but serious bone marro fibrosis, hematologic malignancy, thrombembolic events, eltrombopag, hepatotoxic |
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Term
nursing interventions of romiplostim and eltrombopag |
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Definition
wekkly subq injections with dosage based on platelet count for romiplostim, discontinued if platelets exceed 400 x 10^9 Eltrombopag: PO and rarely used |
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Term
increases HSCs before bone marrow ablation in non hodgkin lymphoma and multiple myeloma |
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Definition
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Term
side effects of plerixafor (mozobil) |
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Definition
injection site reactions, diarrhea, nausea, dizzinesses |
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Term
nursing interventions for plerixafor |
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Definition
subq, given on specific schedule r/t HSC harvest, dosage reduced in patients iwth reduced renal function |
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Term
leukopoietic growth factors |
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Definition
figrastim, pegfilgrastim, sargramostim |
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Term
stimulat production of white blodo cells to decrease risk of infection in patients on chemotherapy or having bone marrow transplantation |
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Definition
leukopoietic growth factors |
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Term
side effects of leukopoietic growth factors |
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Definition
diarrhea, weakness, rash, malais, bone pain uncommon pleural and pericardial effusion |
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Term
nursing interventions for leukopoietic growht factors |
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Definition
routes and dosages specific to each drugs, schedule based on chemotherpay or bone marrow tranplantation |
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Term
drugs for deficiency anemias |
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Definition
oral iron preparations, parenteral iron preparation, oral and parenteral vitamin b12, hydroxyurea |
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Term
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Definition
ferrous iron salts (feosol, fer in sol, fergon, ferro-sequels) |
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Term
side effects of oral iron perparations |
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Definition
constipation or diarrhea, black stools, mild nausea, heartburn. can aggravate peptic ulcers, ucerative colitis, regional enteritis, toxic in larg ammount |
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Term
nursing interventions for oral iron preparations |
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Definition
give with food initially then trasisition to between meels for best absorption, give with food only if GI effects are intolerable, if the patient is taking liquid iron dilute the drug and administer it through a straw to prevent stianing the teeth |
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Term
parenteral iron prparations |
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Definition
iron dextran (only parenteral form approved for iorn deficiency of all causes) |
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Term
side effects of parenteral iron preparations |
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Definition
hypersensitivity reaction, brown skin discoloration at the injection site |
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Term
nursing intervention for paretneral iron preparation: iron dextran |
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Definition
test does before starting treatment, IV prefered, give IM injections only in the upper, outer quadrant of the buttock using z track technique |
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Term
oral and parenteral iron preparation |
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Definition
vitamin b12 (cyanocobalamin) |
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Term
intranasal iron preparation |
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Definition
cyanocobalamin (nascobal) |
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Term
side effects of vitamin b12 reblacement |
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Definition
diarrhea, hypokalemia, itching, rash at injection site, rarely heart fialure, anaphylaxis |
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Term
nursing interventions for oral and parenteral vitamin b12 |
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Definition
given PO, intranasal, IM or deep subq injection, must be given for rest of the person's life, with intranasal preparation, no hot food for one hour before or after drug administration |
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Term
use and action of hydroxyurea (droxia) |
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Definition
prevention of sickle cell crisis |
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Term
side effects of hydroxyurea |
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Definition
nausea, vomiting, sever bone marrow supression, contraindicaed during pregnancy |
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Term
nursing interventsions for hydroxyurea (droxia) |
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Definition
reinforc to the patietn that this drug must be take regularly to prevent sickle cell crises and is no use once a crisis occurs, monitor blood cell counts frequently |
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