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Hematologic and Systemic Retinal Disease
Ocular Disease III Exam 2
76
Medical
Graduate
03/01/2013

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Cards

Term
Term for % of red cells in whole blood
Definition
Hematocrit
Term
5 types of white blood cells in the blood
Definition
Neutrophils
eosinophils
basophils
lymphocytes
monocytes
Term
Neutrophils are associated with what type of infection
Definition
bacterial
Term
eosinophils are associated with what type of immune response
Definition
Allergies
Term
Lymphocytes are associated with what type of infection
Definition
Viral
Term
Monocytes are associated with what type of infection
Definition
Viral
Term
clinical term for total occlusion of a vessel
Definition
infarction
Term
flame shaped hemorrhage with white center
Definition
Roth spots
Term
Systemic symptoms of Anemia
Definition
Pallor, weakness, lethargy, dyspnea
Term
Hemoglobin levels (in anemia) where retinal changes start to occur
Definition
Concentration falls to half of the normal value
Term
Name 4 manifestations of vascular occlusion in the retina
Definition
Flame shaped hemes
dot/blot hemes
Roth spots
Cotton wool spots
Term
Where are boat hemorrhages located?
Definition
Interface between retina and vitreous, blood has leaked through the ILM
Term
Lack of which vitamin can cause anemia
Definition
Vitamin b12
Term
Most common type of anemia in the US
Definition
Iron deficiency Anemia
Term
Name 3 factors that contribute to anemia in women
Definition
Menstrual blood loss
inadequate intake
poor absorption
Term
Pernicious Anemia is due to a lack of which substance in the body?
Definition
Intrinsic factor, disrupts the ability to absorb Vitamin B12
Term
Treatment of Pernicious Anemia
Definition
Sublingual/Parenteral vitamin supplements
Term
3 causes of Hemolytic anemia
Definition
Infections Medications or autoimmune
Term
Which body organ removes old and damaged RBCs from the blood
Definition
Spleen
Term
Accumulation of which hemoglobin breakdown product 'causes' jaundice
Definition
Bilirubin
Term
Term for anemia caused by the premature destruction of RBCs
Definition
Hemolytic anemia
Term
Term for anemia caused by an inefficiency to make enough RBCs due to bone marrow damage
Definition
Aplastic Anemia
Term
Name 4 causes of Aplastic Anemia
Definition
Viral infection, toxic chemicals, medications, radiation
Term
How is Sickle Cell Hemoglobin different from normal Hb?
Definition
a mutation in one amino acid on the beta chain causes a sickle shape
Term
What causes HbS (sickle cell) to distort into the characteristic shape
Definition
low oxygen levels
Term
Inheritance pattern of sickle cell disease
Definition
Recessive, defect is co-dominant
Term
7 signs of sickle cell disease in a child
Definition
Fatigue, breathlessness, rapid heart rate, delayed growth/puberty, susceptibility to infections, chest pain, decreased fertility
Term
In Sickle Cell dz how does the retina respond to microvascular occlusions
Definition
Makes shunt vessels between arterioles and small veins
Term
How is a shunt vessel different from a collateral?
Definition
Shunt=artery to vein, Collateral= artery to artery
Term
Sea fan neo is associated with which disease
Definition
Sickle Cell anemia
Term
Laser photocoagulation is a treatment for what sign of retinal disease
Definition
Neovascularization
Term
What is primary polycythemia
Definition
When the bone marrow overproduces blood cells (abnormal)
Term
What is secondary polycythemia
Definition
Overproduction of erythropoeitin by the kidneys causes increased production of erythrocytes
Term
Some symptoms/signs of polycythemia
Definition
fatigue, headaches, forgetfulness, vertigo, vascular congestion, red complexion, hypertension, hepatosplenomegaly, skin/mucous membrane hemorrhages
Term
Ocular presentation of polycythemia
Definition
Bilateral amaurosis fugax
hemianopia
unformed hallucinations
blur
Term
Clinical term for sudden, painless, temporary loss of vision
Definition
Amaurosis Fugax
Term
What RBC count indicates risk for retinal changes in terms of polycythemia
Definition
6 x 10^6/mm^3
Term
Polycythemia-how does this condition affect the appearance of BV in the retina
Definition
Veins are more dilated than normal, vasculature appears tortuous
Term
Clinical term for neoplastic proliferation of WBCs in bone marrow
Definition
Leukemia
Term
2 types of leukemia
Definition
Myeloblastic or lymphoblastic
Term
Which age ranges are mostly affected by lymphoblastic anemia
Definition
Most under age 10
Term
Which age ranges are mostly affected by megaloblastic anemia
Definition
Mostly adults, but can happen in all ages
Term
What proportion of leukemia cases have ocular findings?
Definition
50-70%
Term
Which form of leukemia has more ocular findings, acute or chronic?
Definition
Acute
Term
7 vascular manifstations of leukemia
Definition
Venous dilatio
venous tortuosity
retinal hemorrhages
retinal exudates
cotton wool spots
optic nerve filtration
roth spots
Term
Another term for pre-retinal hemorrhages
Definition
Boat hemorrhages
Term
Cancer involving increased IgM fraction of plasma
Definition
Waldenstrom's Macroglobulinemia
Term
Systemic findings associated with Waldenstrom's Macroglobulinemia
Definition
Weakness, weight loss, recurrent infections, retinal hemorrhages, blurred vision
Term
Retinal vascular disorder associated with increased triglyceride levels
Definition
Lipemia Retinalis
Term
Approx. fasting glucose levels in lipemia retinalis
Definition
>200 mg/dL
Term
Normal range of fasting glucose
Definition
60-120 mg/dL
Term
Normal range of serum cholesterol levels
Definition
120-220 mg/dL
Term
Approx cholesterol levels in Lipemia Retinalis
Definition
>1000 mg/dL
Term
Normal range of triglyceride levels
Definition
50-149 mg/dL
Term
Approx. triglyceride levels in Lipemia Retinalis
Definition
>10 000 mg/dL
Term
Distinctive appearance of vessels associated with lipemia retinalis
Definition
Salmon pink to ivory colored vessels due to high cholesterol levels
Term
The only retinal change noted with lipemia retinalis
Definition
change in color of vasculature
Term
How does lipemia retinalis affect VA
Definition
No affect
Term
Treatment of Lipemia Retinalis
Definition
Diet and meds to reduce triglyceride levels
Term
Which vascular disease tends to affect individuals from Japan and the Meditteranean area
Definition
Behcet's Disease
Term
Triad associated with Behcet's Disease
Definition
Aphthous stomatitis
genital ulcers
recurrent hypopyon iritis
Term
Posterior involvement of Behcet's Dz
Definition
Disc Hyperemia, Cystoid Macular Edema, Ischemic Vasculitis, Deep exudation
Term
Treatment of Behcet's Dz
Definition
topical/periocular steroids, oral steroids or immunosuppresives, photocoagulation
Term
Description of uveitis associated with Behcet's dz
Definition
chronic, bilateral and recurrent
Term
2 organs mostly affected by sarcoidosis
Definition
Lungs and lymph nodes
Term
Most common initial symptoms of sarcoidosis
Definition
persistent dry cough, fatigue, shortness of breath
Term
Indicated diagnostic test of sarcoidosis
Definition
ACE
Term
Calcium levels in sarcoidosis
Definition
Abnormal calcium metabolism results in hypercalcemia
Term
Sarcoidosis: 8 forms of ocular involvement
Definition
chronic dacryoadenitis, granulomatis anterior uveitis, conjunctival lesions, vitiritis (pearl strings), periphlebitis/candle wax drippings, retinal vein occlusions/hemorrhages, disc edema, ON granulomas
Term
3 characteritics of granulomatous uveitis in sarcoid
Definition
Bilateral , mutton fat KPs, iris nodules
Term
6 important complications to manage in sarcoid pt
Definition
Dry Eye, Cataracts (uveitis and steroids), Anterior Uveitis, Seondary Glaucoma,Disc edema, neo
Term
What proprotion of sarcoidosis cases are fatal
Definition
5-10%
Term
Name 3 ethinicities that have a higher incidence of SLE than Caucasians
Definition
African, American Indian, Asian
Term
7 diagnostic features of SLE
Definition
4+ of
Malar Rash
Discoid rash
Photosensitivity/sun rash
oral ulcers
arthritis
serositis
renal disorder/proteinurea
Term
Most diagnostic test for SLE currently available
Definition
ANA (Anti-nuclear Antibody)
Term
6 drug types used in treatment of SLE
Definition
NSAIDS
Acetaminophen
Steroids
Antimalarials
Immunomodulators
Anticoagulants
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