Shared Flashcard Set

Details

Hard Tissue
Exam 1
158
Pathology
Graduate
10/30/2012

Additional Pathology Flashcards

 


 

Cards

Term
first bone to ossify
Definition
clavicle
Term
asses spinal maturation by the closure of the iliac crest
Definition
Risser's sign
Term
Epiphysis
Definition
the end of growing bone
produce and support articular cartilage
Term
Physis
Definition
longitudinal growth
periosteum for bone width
ab[N] length is Dwarfism or Giantism
Term
Metaphysis
Definition
most active part of bone
most prone to tumors and infections
Term
Diaphysis
Definition
longest part of bone aka= shaft
thickened cortex
decreased medullary space
main function is mechanical strength and contains bone marrow
Term
Pathologies of Diaphysis
Definition
Multiple Myeloma
Ewing's sarcoma
Non-Hodgkin's lymphoma
infection
Term
cortex
Definition
densest and strongest of all bone
thickness and integrity is a strong indicator of bone tumors, infection etc
Term
medulla
Definition
internal cavity of bone
contains bone marrow
Term
Periosteum
Definition
not normally seen on xray
around diaphysis and metaphysis
none around epiphysis
Term
2 layers of periosteum
Definition
outer layer = attachments
inner layer = metabolically active = osteoblastic and osteoclastic potential
Term
endosteum
Definition
covers inner cortical margins
Term
Vertebral body development: Age 0-1
Definition
vertebral body is ovoid/egg-shaped with slightly rounded anterior margins. The body = disc height
Term
Vertebral body development: Age 2-5
Definition
vertebral body assumes more of a rectangular shape
Term
Vertebral body development: Age 6-8
Definition
steplike recesses are seen in the vertebral bodies above and below
Term
congenital
Definition
localized and generalized skeletal anomalies
ex spinal block vertebrae
Term
trauma
Definition
injuries
e.g. fractures, subluxation, dislocations and soft tissue ab[N] such as myosistis ossificans
Term
arthritis
Definition
joint problems
alternations in alignment, articular contour and joint space are identifiable
Term
tumor/lesion
Definition
neoplastic conditions
B9 or malignant
recognized by productive and destructive features
Term
Infection
Definition
infective disorders of bone (osteomyelitis)
infective disorders of joints (septic arthritis)
difficult to differentiate from tumors
Term
hematologic
Definition
characterized by origin in bone marrow
e.g. hemolytic anemias and absence of blood supply as in epiphyseal avascular necrosis
Term
nutritional, metabolic, endocrine
Definition
broad category
nutritional osteopenias - scurvy rickets
parathyroid diseases (metabolic)
Term
parathoromone (PTH)
Definition
increases serum calcium by promoting bone, kidney and gut resorption of calcium
Term
calcitonin
Definition
antagonistic to PTH and actively decreases serum calcium
Term
estrogen
Definition
stimulates bone production
closely controls longitudinal growth and maturity
Term
androgen
Definition
male counterpart of estrogen
controls longitudinal growth and maturity
Term
growth hormone (GH)
Definition
absence during growth (child) = dwarfism
excess during growth (child) = giantism
excess in adult - acromegaly
Term
glucocorticoids
Definition
most important one effecting bone = hydrocortisone
Term
open fracture
Definition
skin penetrated over fracture site
Term
closed fracture
Definition
skin not broken
Term
comminuted fracture
Definition
3 or more bony fragments
Term
non-comminuted fracture
Definition
2 fragments
fracture completely through bone
eg Jefferson's Fx
Term
Avulsion Fx
Definition
portion of bone torn away by muscular or ligamentous pulling
Term
impaction fracture or compression fraction
Definition
portion of bone driven into adjacent segment
Term
pseudo fracture aka Loser's Lines
Definition
imcomplete fracture
often multiple
associated with Paget's, Rickets, Osteomalacia of Fig Dysp
Term
greenstick fracture
Definition
infancts, children < 10
bone bends: increased pressure to convex side we produces transverse fx with concave side intacts
heals w/o complications
Term
torus fx
Definition
due to compressive force the cortex bulge outward
Term
chip fx
Definition
forms avulsion
Term
occult fx
Definition
fx that gives clinical signs a/o radialogic evidence
7-10 days later resorption of bone mated at fx site
Term
bone bruise
Definition
only visible w/ MRI in traumatic injuries
respresents hemorrhage of edema associated with trabecular micro fx
Term
Type I classification of epiphipeal fxs
Definition
isolated fx thru growth plate
x-rays appears [N]
Term
Type II classification of epiphipeal fxs
Definition
fx through a displaced growth plate, carries a corner of the metaphysis
Most common
Term
Type III classification of epiphipeal fx
Definition
fx along growth plate toward epiphysis
most freq site = disal tibial
Term
Type IV classification of epiphipeal fx
Definition
compressive deformity of growth plate
least common of all salter harris fx
Term
Radiological feature of healing fractures within the first 5 days
Definition
resportion of fracture line
result --> increase in width of actural fx line
Term
radiological features of healing fractures in 10-15 days
Definition
"veil" of new bone formed adjacent to fx site
Term
how long does the healing process take?
Definition
4-6 weeks in young patient
6-12 weeks in geriatric patients
there is a complete absence of fx line
Term
complications of fx
Definition
arterial injury
fat embolism syndrom
thromboembolism
Term
basal skull fx
Definition
bruise appears behind mastoid
battle sign
associated with clear nasal discharge
Term
Jefferson's fracture
Definition
aka bursting fracture
fxs through anterior and posterior arches
lateral mass spread apart
associated with ruptured transverse ligament
Term
Hangman's Fx
Definition
most commone injury of cervical spine
bipedicular fx of C2
associated with anterior displacement of C2 on C3
Term
Mechanism of Hangman's Fx
Definition
usually a MVA with abrupt deceleration; fracture occurs during hyperextension/rotary force
Term
Type I Odontoid Fx
Definition
Odontoid Tip
Term
Type II - Odontoid Fx
Definition
**most unstable
fx at junction of base and body
most common type and most frequent not to heal
Term
Type III Odontoid Fx
Definition
odontoid base w/ extension into body
most readily to heal
Term
Vertebral Body compression fx
Definition
sharp, triangular, anterior wedging of superior end plate
ant body height 3mm < post. body height
most common fracture of lumbar spine
Term
Clay Shoveler's Fx
Definition
aka coal-miner's fx
SP avulsion fx
usually at C7; then C6
A-P view shows a double spinous sign
Term
Whiplash Syndrome
Definition
soft tissue injury
alordosis
arcual kyphosis
segmental flex/ext
Term
bilateral interfacetal dislocation
Definition
highly unstable
body of segment is displaced anteriorly
superior facets are post to inf facets of vertebra above
post zyg ant to pre-zyg of vertebra below
Term
chance fx aka Lap Seatbelt Fx
Definition
transverse fracture through pedicles, pars, lamina, and SP
usually by way of a MVA
Term
Transverse Process Fx
Definition
2nd most common fx of lumbar spine
assoc with hyperextension w/ lateral flexion - avulsion of paraspinal mm
Term
Colle's Fx
Definition
fx of distal radius with posterior angulation of distal fragment
assoc with fall on an outstreched, extended hand
Term
Smith's Fx
Definition
fx of distal radius with anterior angulation of distal fragment
associated with direct blow with wrist in hyperflexion
Term
Galeazzi
Definition
aka piedmont or reversed monteggia
fx of distal radial shaft at junction of middle and distal thirds with dislocation of distal radio ulnar joint
Term
post traumatic myositis ossificans
Definition
heterotrophic bone formation in soft tissue
most often in muscle, but can be in fascia, tendons, joint capsules and ligaments
Term
What is the anatomical/ radiological correlation of the arthritides?
Definition
A = alignment
B = bone
C = cartilage (soft tissue)
Term
Enthesis
Definition
anatomical term for transition zone between bone and ligament and tendon
Term
Enthesopath
Definition
inflammatory cellular infiltrate at the bone/ligament or bone/tendon junction. Seen in inflammatory arthritides, esp, AS as cortical erosion and periostitis
Term
Erosion
Definition
loss of bone due to pressure atrophy or active breakdown of bone tissue
Term
monoarticular
Definition
single joint involved
Term
pauciarticular
Definition
2 - 4 joints are involved in the disease processs
Term
polyarticular
Definition
> 4 joints involved
Term
osteophyte
Definition
degenerative bony outgrowth continuous with underlying cortex, covered with cartilagenous cap, occuring at insertion of capsular ligament
Term
rheumatoid variants
Definition
inflammatory arthropathies simulate RA clincally w/o RA factor show different pathological and radiographic features
Term
syndesmophyte
Definition
inflammatory ossificans w/i spinal ligament
Term
periostitis
Definition
localized periosteal new bone; seen in inflammatroy arthritides
Term
ossification
Definition
usually between ALL or PLL; usually in DISH
Term
what must be present in order for something to be diagnosed as osteoarthritis?
Definition
L - non uniform loss of joint space
O- osteophytes
E - eburnation
Term
What are the radiological features of DDD/DJD/ OA
Definition
Must have LEO
loose bodies
subchondral cysts
Vacuum sign
Gull Sign
Term
vacuum sign
Definition
seen in OA/DDD/DJD
linear radiolucency in the disc space; represents collection of nitrogen gas in nuclear and annular fissures
Term
Gull Sign
Definition
biconcave articular contour at distal and proximal interphalangeal joints (DIP & PIP)
Term
Herberden's Nodes
Definition
Gull sign at the DIP
Term
Bouchard's Nodes
Definition
Gull sign at the PIP
Term
Diffuse Idiopathic Skeletal Hyperostosis (DISH)
Definition
ligamentous ossification; esp ALL interupted by discal extensions
Term
What are the radiological features of DISH?
Definition
flowing ossification of at least 4 contiguous segments
[N] disc height
hyperostosis; usually anterior
"flame configuration"
50% ossification of PLL
Term
Rheumatoid Arthritis
Definition
muscle soreness
morning stiffness
systemic connective tissue disease wc targets synovial tissue; early = symmetrical peripheral joint pain and swelling esp in hands
later = deformities such as ulnar deviation, swan neck and boutonniere
Term
boutonniere
Definition
Ext of DIP
Flex of PIP
seen in RA
Term
swan neck
Definition
Flex of DIP
Ext of PIP
seen in RA
Term
what lab findings is present in RA
Definition
RA factor is present
elevated ESR
Term
What are radiological features of RA?
Definition
bilateral and symmetrical
periarticular soft tissue swelling (pannus)
juxt-articular osteoporosis
uniform loss of joint space
Rat bite erosions
Term
What should you always check for in a patients hand when suspecting RA?
Definition
Styloid Process
carpel bones MCP's and PIP's
Term
What are the most common affected areas of RA in the cervical spine?
Definition
increased ADI space
Decreased IVD space
generalized osteoporosis
Term
OTTO's Pelvis
Definition
Bilateral acetabular protrusion due to RA
Term
Juvenile RA
Definition
aka Still's Disease
present before the age of 16
present with fever, a characteristic rash, lymphadenopathy
**Lacks a positive RA factor
Term
Radiological features of Juvenile RA
Definition
soft tissue swelling
osteoporosis
periostitis
ankylosis
loss of joint space
erosions
subluxations
Term
Where are the target sites for Juvenile RA?
Definition
Cervical spine
hands
feet
knees
Term
What happens in the cervical spine during Still's Disease?
Definition
posterior motor unit fusion between C2-C3-C4-C5
Term
Ankylosis spondylitis
Definition
tenderness over boney protuberances
bilateral sciatica
onset between 15-35 males
pain
Term
Lab findings for AS
Definition
+ HLA- B27
Term
Radiological features of AS.
Definition
Bilateral and Symmetrical Ankylosis of the SI Joint
Syndesmophyte formation (marginal)
bony ankylosis
erosions with surrounding sclerosis
Bamboo Spine/ Poker Spine
Trolley track sign
Carrot stick fracture
Term
Psoriatic Arthritis
Definition
associated with psoriasis
between 20-50
usually in the DIP joints
Term
Describe the lesions present with Psoriatic Arthritis.
Definition
well defined, dry, raised red and silvery, scaly patches
Term
What is the lab finding for Psoriatic Arthritis?
Definition
- RA factor
Term
Radiological features of psoriatic arthritis.
Definition
soft tissue swelling
bone reapsortion (bone disappears)
pencil in cup deformity
most common at DIP shows the Ray Pattern
mouse ears sign
NO ULNAR DEVIATION
increased ADI
Term
Osteitis Condensans IIii
Definition
bilateral, symmetrical SI disorder
multiparous females
usally affect women 20-40
self-limiting
no lab findings
asymptomatic
Term
Radiological features of Osteitis Condensans
Definition
bilateral dense, triangular shaped iliac subchondral sclerosis
lower 1/2 of joint
joint space and margins [N]
Term
Osteitis Pubis
Definition
inflammation usually following pelvic surgery or childbirth
pain restricted movements
Term
Radiological features of osteitis pubis
Definition
joint surface erosion
subchondral sclerosis
motheaten localized osteoporosis
widened joint space
looks identical to infection
Term
Gout
Definition
ab[N] purine metabolism
sodium monourate crystals in cartilage usually lower extremities
in males usually 40's and 50's
Term
Lab findings for Gout
Definition
increased ESR
leukocytosis
hyperuricemia
Term
Radiological features
Definition
classic "over-handing margin sign"
marginal bone erosions
Term
Targeted areas
Definition
1st metatarsophalangeal joint
hands
wrists
Term
Hydroxyaoatite Deposition Disease (HADD)
Definition
calcification within tendon, bursa, other periarticular soft tissue
AKAs calcifying tendinitis
peritendinitis calcarea
Term
Where is HADD most commonly seen?
Definition
shoulder
hip cervical spine
Term
radiological features of HADD
Definition
shoulder: supraspinatous tendon
hip: gluteus maximus tendon is most common
Nucleus pulposus calcification
annulus fibrosis calcification
may also see calcified thyroid cartilage, stylohyoideous, and iliolumbar lig
Term
Neurotrophic Arthropathy
Definition
aka Charcot's Joint
lack of objective and subjective pain despite joint swelling, instability, and crepitation
destructive articular disease which occurs secondary to a loss or impairment in joint proprioception
Term
Neurological signs of Neurotrophic Arthropathy
Definition
altered gait patterns; loss of deep reflex; pain insensitivity
2 basic types: hypertrophic and atrophic
Term
Hypertrophic - the 6 D's
Definition
Distension
Density
Debris
Dislocation
Disorganization
Destruction
Term
Where does hypertrophic normally exist?
Definition
In weight bearing bones
Term
Atrophic
Definition
More common in shoulder hip, foot
articular ends appear surgically amputated or tapered
licked candy stick
absence of 6 D's
Term
Characteristics of Neurotrophic Arthopathy in the lumbar spine
Definition
large osteophytes, prominent sclerosis, advanced discopathy, severe subluxations and body fragmentation
Term
Lab findings for Neurotrophic Arthopathy
Definition
(-) for joint disease
(+) for causitive disease eg syphillis, diabetes
Term
Onchronosis
Definition
aka Alkaptonuria
ab[N] tyrosine metabolism - urine turns black upon standing
arthritis - insidious onset of back pain and joint stiffness
Term
Radiological Features
Definition
premature DDD
chondrocalcinosis
ligament calcification
Term
Radiological features in the spine
Definition
universal discal calcification
decreased disc space - waffer thin disk
calcification of interspinous ligament
begins in lumbarsl ascends spine
Term
Sarcoidosis
Definition
rare spinal involvement
formation of noncaseating granulomas
Term
Radiological features
Definition
most common - hand, wrist, feet
coarsened trabecular with numerous areas of decreased density (lace- like)
2nd most common area is chest
Term
Lab findings of Sarcoidosis
Definition
increased ESR
reversed A-G ratio
hypercalcemia
(+) Kviem test
Term
Calcium Pyrophosphate Dihydrate Crystal Deposition
(CPPD)
Definition
inflammatory joint ds caused by deposition of CPPD into synovial fluid, linings and articular cartilage
Term
What are the clinical features of CPPD
Definition
acute - stimulates Gout or RA
Chronic - stimulates DJD
Asymptomatic - the only sign is chondrocalcinosis
Term
Radiological features
Definition
soft tissue calcification
cartilage calcification - most common in knees
Term
Terry Thomas sign
Definition
present in the wrist a step ladder appearance
the scaphoid moves proximally and the lunate moves more distally
Term
Where are the crystal deposition in Gout and CPPD
Definition
in gout the crystals are around the joint
CPPD the crystals are within the joint
Term
Synoviochondrometaplasia (SCM)
Definition
B9 arthropathy
synovial tissue undergoes metaplasic transformation -- forms cartilage
calcifies -- ossifies -- loose bodies
joint mice
Term
The most comone site for SCM
Definition
** knee, hip, ankle, elbow, wrist
Term
radiological features of SCM
Definition
each loose body in the joint is round, oviod, smooth, faceted, laminated and strippled
may have internal trabeculae
Term
What are the congenital fusions?
Definition
Occipitalization
basilar impression
block vertebra
Term
occipitalization
Definition
fusion of C1 to base of occiput
lack of segmentation and separation of most caudal occipital sclerotome
Term
Basilar impression
Definition
decrease space of non-existent space between C1 and occiput
Term
Arnold Chiari
Definition
inferior portion of cerebellar hemispheres and medulla protrude thru FM into spinal canal; usually accompanied by spina bifida and meningomyelocele
Term
Block vertebra
Definition
2 adjacent vertebra osseously fused from birth
failure of [N] segmentation
causes stress above and below block results in premature degeneration
Term
Where are the most common occurence of blocked vertebra?
Definition
C5/C6
C2/C3
T12/L1
L4/L5
Term
Radiological features of blocked vertebra
Definition
anterior concavity forming a "C" shape
wasp waist
Term
What are the pathological fusions?
Definition
Klippel Feil Syndrome
Sprengel's Deformity
Acquired Block Vertebra
Term
Klippepl Feil Syndrome
Definition
classic triad
short webbed neck
low hairline
Term
Radiological features of Klippel Feil Syndrome
Definition
2 or more blocked vertebrae in cervical or upper thoracic region
Term
Sprengel's Deformity
Definition
patient will have decreased abduction of arm, and torticollis
associated with omovertebral bone (30-40%)
Term
Accessory Articulation
Definition
anytime an atypical bone forms a joint space with normal anatomy
Term
Acquired block vertebra
Definition
Lack of anterior concavity
aka ankylosis
Term
Radiological features of acquired block vertebra
Definition
no neural arch fusion
considered an E shape
osteophytes generally present
Term
Spondylolisthesis
Definition
interruption of pars interarticularis
ant displacement of vert body with vertebrae below
Term
Radiological Feautures of Bowline of Brailsford
Definition
inverted Napolean's Hat Sign
Term
Spondylolysis
Definition
an interruptions of the pars interarticularis; this may be wither unilateral or bilateral
Term
Type I spondylolisthesis
Definition
Dysplastic congenital ab[N]
Term
Type II spondylolisthesis
Definition
Isthmic - lytic or stress fracture of pars; elongated but intact, acute fx of pars
Term
Type III spondylolisthesis
Definition
Degenerative - 2 degrees to long standing degenerative arthrosis of zyg joints without pars separation
Term
Type IV spondylolistheis
Definition
Traumatic - 2 degrees to a fx to the neural arch
Term
Type V spondylolisthesis
Definition
Pathological - in conjunction with bone disease (Pagets, mets)
Supporting users have an ad free experience!