Shared Flashcard Set

Details

Haematology
First Year, Week Three
37
Medical
Undergraduate 1
05/08/2009

Additional Medical Flashcards

 


 

Cards

Term
Haemostasis
Definition
The arrest of cleeding and the maintenance of vascular patency
Term
Primary haemostasis
Definition
Formation of platelet plug
Term
Platelets
Definition
formed in the bone marrow by ‘budding’ from megakaryocytes
Term
Vascular component
Thrombocytopenia
Von willebrand factors
Definition
Causes of failure of platelet plug formation
Term
Bruising, purpura
Mucosal bleeding
Intracranial and retinal haemorrhages
Definition
Consequences of platelet plug formation
Term
Haemophillia
Definition
Example of failure of fibrin clot formation as a result of Single clotting factor deficiency
Term
Factor VIII - IXa - Activated Partial Thomboplastin time (APTT)
Definition
Screening tests for fibrin clot formation for the INTRINSIC pathway
Term
Factor V11a - Tissue Factor - Prothrombin Time (PTT)
Definition
Screening tests for fibrin clot formation for the EXTRINSIC pathway
Term
Anti-Thrombin
Definition
Type of anticoagulant important in inhibition of the terminal proteins of the cascade
Term
Heparin
Definition
Increases activity of anti-thrombin On interaction
Term
Protein C
Definition
Vitamin K dependant plasma protein which inactivates co factors Va and VIIIa as well as stimulating fibrinolysis
Term
Thrombophilia
Definition
Deficiency of naturally occuring anticoaqulants. Sufferers have increawed tendency of developing DVT
Term
APTT
Definition
Time effected my haemophillia
Term
stasis
vessel wall
Hypercoagulability
Definition
Three components of Virchows triad
Term
Warfarin/heparin
Definition
Treatment of venous thrombosis
Term
Hot. swollen tender limbs with pitting oedema
Definition
Symptoms of venous thrombosis
Term
Pulmonary infarction
Chest pain
Hypoxia
Right heart strain
CardioVascular collaspe
Definition
Pulmonary embolism can lead to
Term
Thrombin
Definition
Important in switching on/amplification of the intrinsic pathway
Term
Heparin
Definition
Anticoagulent drug which allows anti-thrombin to bind to its target, stabilising the structure
Term
APTT
Definition
Monitoring used for heparin
Term
Bleeding - overdose
Heparin induced thrombocytopenia
Osteoporosis - long term use
Definition
Complications of Heparin
Term
Protamine sulphate
Definition
Used in severe bleeding caused by heparin overdose, reverses anti-thrombin effect
Term
Warfarin
Definition
Anticoagulant that works by antagonising Vitamin K
Term
Greater Prothrombin Time
Definition
More Warfarin = less VII + X present which does what to PT
Term
INR
Definition
Equation used to monitor patients on warfarin
Term
Haemorrhage
Bleeding
Definition
Adverse effects of warfarin
Term
Arterial Thrombosis
Definition
Plaque ruptures, platelets adhere, in high pressure environment, causes damage to endothelium
Term
Hypertension
Smokinh
High cholesterol
Diabetes
Definition
Risk factors of Arterial thrombosis
Term
Thrombolysis
Antiplatelet drugs - Aspirin and clopidogrel
Definition
Treatment of Arterial Thrombosis
Term
Venous Thrombosis
Definition
occurs in low pressure system mainly by stasis and platelets are not activated, slow onset
Term
Fibrin
Definition
Stasis in venous thrombosis activates th coagulation cascade forming a clot rich in
Term
Obesity
Malignancy
Pregnancy
Surgery
Immobility
Anything resulting in stasis
Definition
Risk factors for venous thrombosis
Term
Anticoagulant drugs - warfarin , heparin
Definition
Treatment for VT
Term
warfarin
Definition
vitamin K antagonist
Term
increased fibrinolysis
Definition
Elevated D-dimers are an indicator of
Term
The Factor V Leiden mutation (activated protein C resistance)
Definition
the commonest known cause of inherited thrombophilia.
Term
Plasmodium falciparum
Definition
can cause cerebral malaria and death
Supporting users have an ad free experience!