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Gram Positive Cocci
Exam 2
65
Pathology
Professional
04/30/2011

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Term
Why are Gram-pos organisms able to retain the crystal violet stain?
Definition
high amount of peptidoglycan in the cell wall
Term
What do Gram-pos cell walls lack that Gram-neg do not?
Definition
outer membrane
Term
major gram-pos cocci
Definition
staph and strep
Term
Staphylococci are catalase-________.
Definition
positive
Term
Streptococci are catalase-_________.
Definition
negative
Term
coagulase positive staph
Definition
S. aureus
Term
coagulase negative staph
Definition
S. epidermidis
S. saprophyticus
Term
beta-hemolytic streps
Definition
Strep pyogenes
Strep agalactiae
Term
group A strep
Definition
Strep pyogenes
bacitracin sensitive
Term
group B strep
Definition
Strep agalactiae
bacitracin resistant
Term
gamma-hemolytic strep
Definition
Enterococcus
Term
alpha-hemolytic strep
Definition
Strep pneumoniae
Strep viridans
Strep mutans
Strep sanguis
Term
What is the most pathogenic gram-pos cocci for humans?
Definition
S. aureus
Term
How is S. aureus typically identified?
Definition
coagulase test (positive)
all other staphs are negative
Term
Beta hemolytic organisms are identified how?
Definition
complete hemolysis of erythrocytes, so blood agar turns clear
Term
Alpha hemolytic organisms are identified how?
Definition
partial or green hemolysis of erythrocytes, so blood agar turns green
Term
Gamma hemolytic organisms are identified how?
Definition
no hemolysis, so blood agar does not change
Term
Staph is arranged in...
Definition
clusters
Term
Strep is arranged in...
Definition
strings
Term
What will you see in the lungs of a patient with Staphylococcal pneumonia?
Definition
multiple, coalescing, small abscesses
Term
What do S. aureus colonies look like?
Definition
large, smooth, translucent, creamy-yellow to golden colored, beta-hemolytic

in pairs and irregular grapelike clusters
Term
What is the hallmark of staphylococcal infection?
Definition
abscess/pus
Term
What causes sloughing of the skin in scalded skin syndrome?
Definition
staphylococcal exotoxin
Term
What causes a post-influenza staph pneumonia?
Definition
influenza virus suppresses/destroys the respiratory ciliary defenses which allows colonization of staph
Term
S. aureus has _________ but no _________.
Definition
exotoxins; endotoxins
Term
lobar consolidation with rapid destruction of lung tissue, resulting in cavitations
Definition
S. aureus
Term
function of protein A
Definition
binds IgG and prevents opsonization (phagocytosis of the bacteria)
Term
function of coagulase
Definition
forms fibrin around the bacteria
Term
function of hyaluronidase
Definition
breaks down connective tissue
Term
What is used to differentiate S. aureus from S. epidermidis and other Staph sp.?
Definition
coagulase enzyme

S. aureus is coagulase +
all other staph sp. are coagulase -
Term
What gram-pos organism is the leading pathogen for nosocomial infections?
Definition
S. epidermidis

associated with intravascular devices, prosthetic joints, catheters, large wounds
Term
What allows bacteria to survive in the presence of oxygen products?
Definition
catalase
Term
S. aureus bacteria pneumonia modes of transmission
Definition
aspiration (usually after onset of influenza)

hematogenous (IV drug use with concurrent heart valve infection)
Term
gram-pos diplococi responsible for pneumonia and many other infections
Definition
Streptococcus pneumoniae
Term
Pneumococci often have a __________.
Definition
capsule
Term
What is the major virulence factor for Streptococcus pneumoniae?
Definition
capsule
Term
What are anti-pneumococcal vaccines based on?
Definition
formulations of various capsular (polysaccharide) antigens derived from the highly prevalent strains
Term
Community-acquired pneumonia with no other underlying disorders most often means...
Definition
Strep pneumoniae
Term
What is the difference between lung infiltrates found in Strep pneumoniae and those found in viral pneumonia?
Definition
localized to one lobe in Strep

diffuse in viral
Term
symptoms of typical pneumonia
Definition
sudden onset
chills/fever
dyspnea
productive cough with purulent sputum
rales
Term
pathogens of typical pneumonia
Definition
Streptococcus pneumoniae (community-acquired)

Staphylococcus aureus (secondary, post viral)
Term
symptoms of atypical pneumonia
Definition
gradual onset
non-productive cough
headache
sore throat
Term
pathogens of atypical pneumonia
Definition
Mycoplasma
Chlamydia
Legionella
viral (uncommon in adults)
Term
pathogen of neonate pneumonia
Definition
group B strep
Term
pathogen of pneumonia in adults/elderly
Definition
Streptococcus pneumoniae
Term
pathogen of nosocomial pneumonia
Definition
gram neg rods
Term
pathogen of aspiration pneumonia
Definition
anaerobes
Term
pathogens of alcoholic pneumonia
Definition
S. pneumoniae
Klebsiella pneumoniae
Term
pathogen of pneumonia associated with IVDA
Definition
S. aureus
Term
another name for streptococcus pneumoniae
Definition
pneumococci
Term
most common cause of community-acquired pneumonia
Definition
streptococcus pneumoniae (pneumococci)
Term
pathogen responsible for strep throat
Definition
Streptococcus pyogenes
Term
What type of strep is Strep pyogenes?
Definition
group A beta hemolytic
Term
clinical manifestations of strep throat
Definition
tonsillar exudate
fever
cervical LAD
Term
pathogen responsible for erysipelas
Definition
Strep pyogenes
Term
pathogen responsible for impetigo
Definition
Strep pyogenes
Term
pathogen responsible for scarlet fever
Definition
Strep pyogenes
Term
What occurs as a delayed sequel to group A streptococcal throat infection?
Definition
rheumatic fever
Term
leading cause of bacterial infection and death among newborns
Definition
group B strep
Streptococcus agalactiae
Term
What does GBS cause in newborns?
Definition
sepsis
pneumonia
meningitis
Term
pathogen responsible for necrotizing fasciitis
Definition
Strep pyogenes
Term
pathogen responsible for native-valve endocarditis
Definition
Strep viridans
Term
gold standard for diagnosis of streptococcal pharyngitis
Definition
throat culture
Term
What can happen in untreated strep pyogenes?
Definition
post-streptococcal glomerulonephritis
Term
common pathogen of otitis media
Definition
Strep pneumoniae
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