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Grad Bio
Lecture 4: Cancer
17
Biology
Graduate
09/19/2012

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Term
Cancer
Definition
this is now a general term for more than 100 diseases that are characterised by uncontrolled, abnormal growth of cells. Cancer cells can spread locally or through the bloodstream and lymphatic system to other parts of the body.

2. Malignant growth resulting from uncontrolled cell division
Term
Carcinogenesis
Definition
the origin or production, development of cancer. Including carcinomas and other malignant neoplasms.
Term
Neoplasm
Definition
New and abnormal growth of tissue, which may be benign or cancerous. An abnormal new mass of tissue that serves no purpose.[[Tissue that has no apparent useful function in the body, such as a [[malignant tumour being a good example; the appendix organ being another (where the tissues that form the appendix have no positive use).
Term
Benign
Definition
Something that does not metastasise and treatment or removal is curative.
Term
Malignant
Definition
Tending to become progressively worse and to result in death. Having the properties of anaplasia, invasion and metastasis, said of tumours.
Term
Carcinoma
Definition
a malignant new growth that arises from epithelium, found in skin or, more commonly, the lining of body organs, for example: breast, prostate, lung, stomach or bowel. Carcinomas tend to infiltrate into adjacent tissue and spread (metastasize) to distant organs, for example: to bone, liver, lung or the brain.
Term
Sarcoma
Definition
A form of cancer that arises in the supportive tissues such as bone, cartilage, fat or muscle.
Term
Lymphoma
Definition
malignant tumour of lymphoblasts derived from b lymphocytes. most commonly affects children in tropical Africa: both Epstein Barr virus and immunosuppression due to malarial infection are involved.
Term
Leukemia
Definition
Malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer.
Term
Stage
Definition
The extent to which cancer has spread from its original site to other parts of the body. Usually denoted by a number from Stage 1 (least severe) to Stage 4 (more advanced). Different lymphoma types have different criteria for staging.
Term
Grade
Definition
Question Mark
Term
Oncogenes
Definition
oncogene is a modified gene, or a set of nucleotides that codes for a protein, that increases the malignancy of a tumor cell. Some oncogenes, usually involved in early stages of cancer development, increase the chance that a normal cell develops into a tumor cell, possibly resulting in cancer. New research indicates that small rnas 21-25 nucleotides in length called miRNAs can control expression of these genes by downregulating them.
Term
Tumor Suppressors
Definition
Cancer-critical genes are grouped into two broad classes, according to whether the cance risk arises from too much activity of the gene product, or too little. Genes of the first class, for which a gain-of-function mutation drives a cell toward cancer, are called proto-oncogenes; their mutant overactive forms are called oncogenes. Genes of the second class, for which a loss-of-function mutation creates the danger,
Term
Caretaker Genes (DNA Repair)
Definition
Question Mark
Term
Gain of Function
Definition
Question Mark
Term
Loss of Function
Definition
Question Mark
Term
Retinoblastoma
Definition
A rare, life threatening eye cancer that was one of the first heritable cancers to be found and documented. Most cases and be found by having a MRI(magnetic resonance imaging) done or by just looking at the persons eye. It will apear as glass on the retina and/or will be red and "puffed" out.
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