Term
|
Definition
adjust offending medications
weight loss
dietary adjustments (less meat and seafood, less alcohol esp beer, less fructose soft drinks, more dairy) |
|
|
Term
|
Definition
acute treatment
full dose until attack has resolved, UNLESS CI (renal insuff) |
|
|
Term
|
Definition
acute gout (<36 hrs)
prophylactically in intercritical periods and when initiating urate lowering therapy
toxicities - diarrhea, neuromyopathy, bone marrow suppression, hematologic abn
not dialyzable, need to renally dose
drug interactions |
|
|
Term
|
Definition
acute treatment
intra-articular if few joints involved
oral |
|
|
Term
|
Definition
IL-1 antagonists
SubQ ACTH |
|
|
Term
Probenecid
Sulfinpyrazone
Benzbromarone
Losartan
Fenofibrate |
|
Definition
uricosurics, used to treat undersecretion
suppress URAT1, dec tubular reabsorption
requires adequate GFR, inc risk stone formation/urinary crystallization, DDI |
|
|
Term
|
Definition
treats overproduction
competitive xanthine oxidase inhibitor, oxypurinol is active metabolite
SE - rash, SJ syndrome, GI, liver enzyme inc, cytopenia
max dose 800 mg daily |
|
|
Term
|
Definition
non-purine selective xanthine oxidase inhibitor
hepatically metabolized
SE - transaminitis |
|
|
Term
|
Definition
converts uric acid to allantoin
prevents/manages tumor lysis syndrome
infusion reactions - anti-uricase antibodies |
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