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Glycolysis
enzymes, intermediates, etc
20
Biology
Undergraduate 1
05/25/2010

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Term
GLUT 1+3
Definition
all cells, continuous and constant transport of glucose into cell
insulin indep
Term
GLUT 2
Definition
liver + pancreas
only open when glucose high
insulin indep
Term
GLUT 4
Definition
muscle and fat - more GLUT4 receptors when insulin / exercise high
insulin DEP, GLUT4 trapped in vessicles
Term
GLUT5
Definition
fructose transporter in small intestine
Term
PFK what kind of enzyme
Definition
allosteric= effectors/inhibitors bind allosterically
Term
bis rather than di?
Definition
bis = 2 P not bound together
Term
net gains
Definition
2 pyruvate
2 ATP
2NADH
2H+
2H2O
Term
net uses
Definition
glucose
2Pi
2ADP
2NAD+
Term
fermentation
Definition
pyruvate-->Co2 + acetaldehyde--> ethanol
NADH-->NAD+
Term
pyruvate--> lactate
Definition
NADH-->NAD+
Term
pyruvate fate 3
Definition
CO2+ ACoA
Term
nad binding domain structure
Definition
in dehydrogenases
4a helices+ 6 b parallel sheets
= ROSSMAN FOLD
Term
what is converted to glycolytic intermeds
Definition
galactose fructose to g and f 6 p
Term
control points
Definition
PKF
Term
PFK control
Definition
inhibited by high ATP allosterically
AMP reverses inhibition
inhibited by low pH
Term
what does AC do?
Definition
2ADP-->ATP + AMP
therefore high AMP indicates energy need
Term
hexokinase control
Definition
inhibited by product g6p
Term
committed step
Definition
f6p->f1,6,bp
Term
pyruvate kinase control
Definition
inhibited by ATP
Term
futile cycles
Definition
between f6p and f1,6bp
rapidly increase flux through pathway but consume ATP
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