Term
|
Definition
| Endogenous glucocorticoid |
|
|
Term
|
Definition
| Inactive until metabolized by 11B-hydroxysteroid DH, glucocorticoid activity |
|
|
Term
|
Definition
| Inactive until metabolized by 11B-hydroxysteroid DH, glucocorticoid activity |
|
|
Term
|
Definition
| 4-6 time more potent than cortisol on anti-inflammatory w/ low mineralocortoid |
|
|
Term
|
Definition
4-6 time more potent than cortisol on anti-inflammatory w/ low mineralocortoid
-depot injections for arthritis |
|
|
Term
|
Definition
-Higher mineralocorticoid activity
Tx: hypoaldosteronism |
|
|
Term
|
Definition
| 18x more potent than cortisol w/ no mineralocorticoid acitivity |
|
|
Term
| Metabolic Effects of Glucocorticoids |
|
Definition
-Antagonizes insulin (^ gluconeogenesis)
-^ muscle catabolism
-^ TG |
|
|
Term
| Glucocorticoid and pregnancy |
|
Definition
- NO 11b-hydroxysteroid DH I in fetal liver, so prednisone in mother's liver is converted to prednisolone, but back to prednisone before fetus sees it
*Use prednisone* |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Toxic to adrenocortical cells, used in adrenal tumors |
|
|
Term
|
Definition
Inhibits steroid 17alpha OHase
Tx: Cushing's disease
Sfx: hepatic dysfxn |
|
|
Term
|
Definition
| Mineralocorticoid receptor antagonist |
|
|
Term
|
Definition
| Short acting B2 agonist in lung (asthma) |
|
|
Term
|
Definition
| Short actingB2-agonist (asthma) |
|
|
Term
|
Definition
| Short acting B2-agonist (asthma) |
|
|
Term
|
Definition
| Long acting B2 agonist (asthma) |
|
|
Term
|
Definition
Useful in pts who cant take B-agonists
(MAOi's or cardiac arrhthmias, unstable angina) |
|
|
Term
| Beclomethasone dipropionate |
|
Definition
| Glucocorticoid used in inhaler to suppress inflammation |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Leukotriene Receptor Antagonist
-Prevents actions of cysteinyl leukotrienes (prophylactic) |
|
|
Term
|
Definition
Leukotriene Receptor Antagonist
-Prevents actions of cysteinyl leukotrienes (prophylactic) |
|
|
Term
|
Definition
Inhibits 5-lipozygenase (formation of lipoxygenase)
-Prophylactice tx of mild asthma |
|
|
Term
|
Definition
Humanized mAnti-IgE ab
-reduces airway responsiveness and need for other drugs |
|
|
