Most common nephrotic syndrome in children

Minimal Change Disease

IF: granular pattern of IC deposition

LM: Diffuse capillary thickening

Membranous Glomerulonephritis

IF: granular pattern of IC deposition

LM: hypercellular glomeruli

Acute poststreptococcal glomerulonephritis

IF: linear pattern of IC depostion

Goodpasture syndrome

IF: deposition of IgG, IgA, IgM and C3 in the mesangium

Berger's disease (IgA nephropathy)

Kimmelstiel-Wilson lesions (nodular glomerulosclerosis)

Membranous glomerulonephropathy

Most common nephrotic syndrome in adults

Diabetic glomerulonephropathy

EM: loss of epithelial foot process

Minimal Change Disease

Nephrotic syndrome a/w Hep B/C

Membranoproliferative glomerulonephritis

Nephrotic syndrome a/w HIV

Focal Segmental Glomerulosclerosis

anti-GBM Ab's, hematuria, hemoptysis

Goodpasture syndrome

EM: subendothelial humps and tram-track appearance

Membranoproliferative glomerulonephritis

Nephritis, deafness, cataracts

Alport syndrome

LM: crescent formation in the glomeruli

Rapidly progressive glomerulonephritis

(Goodpasture, Wegener's, Polyangiitis)

LM: segmental sclerosis and hyalinosis

Focal segmental glomerulosclerosis

Purpura on back of arms and legs, abdominal pain, IgA nephropathy

Henoch-Schonlein Purpura

LM: wire-loop appearance

Diffuse proliferative glomerulonephritis

apple-green birefringence with Congo-red stain under polarized light

Amyloidosis

EM: spiking of the GBM due to electron dense subepithelial deposits

Membranous glomerulonephritis