Term
| Most common cause of ESRD (End Stage Renal Disease) worldwide |
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Definition
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Term
| Top 3 Glomerular diseases causing ESRD in US |
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Definition
1) Diabetes Mellitus
2) HTN
3) GN |
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Term
| Most common cause of Glomerular Disease |
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Definition
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Term
| Nephritic syndrome is caused by? |
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Definition
| severe and acute inflammatory injury to the glomerulus |
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Term
| protein levels in nephritic syndrome? |
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Definition
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Term
1) Classic Cause of Nephritic syndrome-Rapidly progressive glomerulonephritis-Postinfectious GN
2) Current Most common cause in developed countries |
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Definition
1) poststreptococcal GN
2) HIV and Hepatitis C |
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Term
| Most common problem with HIV-associated GN |
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Definition
| nephrotic syndrome caused by focal segmental glomerulonephritis |
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Term
| What group does Poststreptococcal GN usually affect? |
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Definition
| Children ages 2-10 after a pharyngitic infection or skin infection (impetigo, pyoderma) of group A streptocci |
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Term
| IgA Nephropathy (Nephritic syndrome) leading cause of GN worldwide? |
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Definition
| Glomerular Deposits of IgA |
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Term
| IgA Nephropathy more common in what group? |
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Definition
| Males, children and young adults |
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Term
| Anti-glomerular basement membrane disease (anti-GBM). What is it? Associated with lungs? |
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Definition
| nephritogenic antibody directed against part of collagen in GBM, Goodpasture syndrome |
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Term
| What is often seen with anti-GBM? |
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Definition
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Term
| Most common systemic diseases associated with renal vasculitis? |
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Definition
1) Wegener granulmatosis (c-ANCA)
2) microscopic polyarteritis (c-ANCA, p-ANCA)
3) Churg-Strauss syndrome (p-ANCA) |
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Term
| what is the hallmark of nephrotic syndrome? |
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Definition
| protein >3.5g/day, usually 5-15g/day |
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Term
| what is the leading cause of nephrotic syndrome in adults? |
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Definition
| Focal segmental glomeruloscerlosis (FSGS) |
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Term
| What do all focal segemental glomeruloscerlosis pts have? |
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Definition
| a foot process fusion-aleteration in podocyte |
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Term
| thickening of the GBM is characteristic of what? |
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Definition
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Term
| Membranous nephropathy is most common in whom? |
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Definition
| white adults and persons >60 yo |
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Term
| Most common form of primary glomerular disease causign the nephrotic syndrome in children? |
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Definition
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Term
Membranoproliferative glomerulonephritis
1) what is it?
2) What is found often? |
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Definition
1) immune complex mediated glomerular disease (IgG, IgM, C3)
2) HTN |
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