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Details

GI week 3
anti ulcer, antacids, antihelmintics
21
Medical
Professional
02/26/2008

Additional Medical Flashcards

 


 

Cards

Term
Histamine Type - 2 Blocker Names
Definition
Climetidine, Ranitidine, Famotidine, Nizatidine
Term
H-2 Receptor Antagonists MOA
Definition
Reversibly inhibit H2-receptors on the basolateral membrane of parietal cells
Term
H2 Receptor Antagonist AE
Definition
GI, high dose in elderly: CNS (confusion, slurred speech, hallucinations), Cimetidine: (gynecomastia and galactorrhea), blood dyscrasias
Term
H2 Receptor Antagonist DI and Contraindications
Definition
CYP450, can inhibit absorption of agents via increase in gastric pH, reduce dose in renal compromise, caution in pregnancy
Term
Proton Pump Inhibitors Names
Definition
Omeprazole, Lansoprazole, Pantoprazole, Rabeprazole, Esomeprazole
Term
Proton Pump Inhibitors MOA
Definition
Acid-labile pro-drugs, go into parietal cells and can't get out, more effective than H2 receptor blockers and antacids
Term
PPI AE
Definition
Mainly GI, CNS effects
Term
PPI DI/Contraindications
Definition
Omeprazole -CYP450, can inhibit absorption of agents via increase in gastric pH, reduce dose in hepatic dz, pregnancy C for omeprazole, B for all others
Term
Sucralfate (Carafate) MOA
Definition
inhibit ulcerations and mucosal erosion by inhibiting pepsin-mediated hydrolysis of mucosal proteins, makes polymer that sticks to ulcer, also stimulate local prostaglandin production and epidermal growth factor, does not affect pH
Term
Sucralfate AE/Contraindications
Definition
Constipation, Renal failure
Term
Misoprostol (Cytotec) MOA
Definition
A prostaglandin E1 analog, provides protective prostaglandins to gastric mucosa, stimulates bicarb and mucous production, increases mucosal blood flow, decreases pepsin
Term
Misoprostol AE/Contraindications
Definition
Mainly GI, Pregnancy (unless used in off label), IBD
Term
Bismuth MOA
Definition

Increases production of bicarb and mucous and may bind to ulcer site, also antibacterial actions

Term
Bismuth AE/DI/Contraindications
Definition
Constipation, Black stools, LOTS DI, Children/Pregnancy, Antiplatelets/Anticoagulants, Diabetics, Renal failure
Term
Metronidazole (Flagyl) MOA
Definition
Pro-drug activated by electron transfer process creating nitro radicals which kill organism
Term
Metronidazole AE/DI/Contraindications
Definition
Dry mouth, N/V/D, metallic taste, disulfiram-like reaction, induces metabolism of rifampin and anti-seizure meds, alcoholic beverages, CNS dz, hepatic dz, 1st trimester pregnancy
Term
Triple Therapy for H. pylori
Definition
A PPI, Clarithromycin, Amoxicillin or Metronidazole
Term
Quadruple Therapy for H. pylori
Definition
A PPI or H2 receptor blocker, Metronidazole or Clarithromycin, Amoxicillin or Teracycline, Bismuth
Term
H. pylori w/ PCN allergy
Definition
substitute metronidazole
Term
H. pylori w/ metronidazole resistance
Definition
substitute tetracycline, consider quadruple therapy
Term
H. pylori with clarithromycin resistance
Definition
substitute either amoxicillin or tetracycline, consider quadruple therapy
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