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GI/Pulmonary EXAM 3 - Rosselli
GI/Pulmonary EXAM 3 - Rosselli GI Disorders
14
Pharmacology
Graduate
04/13/2011

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Cards

Term
heartburn
abdominal pain
dyspepsia - upset stomach
nausea
vomiting
diarrhea
constipation
gastrointestinal bleeding - melena (upper GI bleed, dark/tarry stools); hematochezia (lower GI bleed)
itching - symptom of hepatobiliary disease, itching of palms of hands and/or soles of feet
Definition
common symptoms associated with GI disorders
Term
patient history is the cornerstone of GI evaluation

should be detailed and chronological

use OLDCARTS during interview

discuss dietary habits

weight changes

travel outside of US

family history of GI disorders

medication history
Definition
patient history that should be obtained when interviewing about GI disorders
Term
injury to GI mucosa:

ASA/NSAIDs
bisphosphonates
corticosteroids
alcohol
warfarin (no injury to GI mucosa, but it injured patient is more likely to bleed)
chemotherapy
iron

cause liver damage:

APAP
amiodarone
statins
methyldopa
PTU
interferon beta
duloxetine

diarrhea, GI symptoms:

antibiotics
Definition
medications that may cause GI injury
Term
assess organ function

screen for certain GI disorders

evaluate effectiveness of therapy
Definition
reasons for lab testing in GI disorders
Term
CBC:
WBC - infection, malignancy
Hgb/Hct - possible blood loss, anemias
PLT - risk of bleeding, malignancy, liver disease

serum chemistry panel (BMP, Chem 7):
BUN and SCr - hypdration status, renal function
Na, Cl, K - electrolyte abnormalities from diarrheal illnessess

liver function tests (LFTs):
PTT and INR (clotting factors made in the liver)- hepatic disease
albumin - hepatic or renal disease
alkaline phosphatase and bilirubin - hepatobiliary disease

measure of liver damage:
ALT and AST (byproduct of cell damage) - liver disease (end stage liver disease, these may be low b/c the liver is so damaged that ALT/AST cannot be produced any more)

amylase and lipase - pancreatic illness

microbiology - stool studies for infectious diarrhea or H. pylori infection
Definition
lab testing for GI disorders
Term
plain x-ray: bowel obstruction and perforation

x-ray with contrast:
barium sulfate usually used - unabsorbably; constipation most common ADR
used to identify mucosal lesions, hiatal hernias, strictures, polyps, tumors, ulcers
Definition
use of an x-ray in evaluating GI disorders
Term
upper GI series: radiographic visualization of the esophagus, stomach, small intestine

observe swallowing of contrast agent - esophageal structure and function

small bowel follow-through - gastric cancer, PUD, esophagitis, gastric outlet obstruction, Crohn's disease

low sensitivity and sepcificity

PATIENT EDUCATION: no eating/drinking 8-12 hours prior to test
Definition
use of an upper GI series in evaluating GI disorders, patient education
Term
lower GI series: radiographic visualization of the colon and rectum

barium enema given during procedure

detects obstructions and lesions

diagnosis of Crohn's disease, ulcerative colitis, colon cancers, and diverticulitis

PATIENT EDUCATION: no eating/drinking 8-12 hours prior to test; bowel cleansing agents administered prior to test
Definition
use of a lower GI series in evaluating GI disorders, patient education
Term
ultrasonography can be used to visualize the gallbladder, liver, pancreas, abdominal wall

differences in reflection of sound waves

can identify gallstones, hepatobiliary and pancreatic diseases

limited by bowel gas and excessive body fat
Definition
use of ultrasonography in evaluating GI disorders
Term
transverse planes of tissue by radiographic beam and computer analysis produces a precise reconstructed image

contrast agents may be used

detects disease of liver, pancreas, spleen, colon (liver cancer, pancreatitis, pancreatic cancer, abscesses, cysts)

PATIENT EDUCATION:

no eating/drinking x4h before

have to drink a lot of water after administration of IV contrast agents to avoid kidney damage

metformin:
patients should stop taking metformin the day of the procedure and 48 hours afterward
get a baseline SCr and a SCr 48h after administration of IV contrast to evaluate renal status
Definition
use of computed tomography (CT) or computed axial tomography (CAT) in evaluating GI disorders, patient education
Term
radiofrequency signals forming a 2-dimensional image

greatest sensitivity for liver tumors
Definition
use of magnetic resonance imaging (MRI) in the evaluation of GI disorders
Term
illuminated optical instrument to inspect the interior of GI tract

inspect intraluminal mucosal lesions and obtain biopsies and washings for cytology studies

common indications: evaluating suspected GI bleed, obstructions, upper abdominal pain, infections (C. difficile colitis), malignancies, colonic lesions, colonic polyps

"conscious sedation" used for procedures

contraindicated for patients w/ severe respiratory distress or cardiac failure

many types:
esophagogastroduodenoscopy (EGD) - visualizes upper GI tract up to the duodenum
colonoscopy
sigmoidoscopy
endoscopic retrograde cholangiopancreatography (ERCP) - inspect pancreas if gallstones as suspected
capsule endoscopy - patient swallows a capsule that has a camera in it

PATIENT EDUCATION:

no eating/drinking x8-12h prior

bowel prep and cleansing prior to colonoscopy or sigmoidoscopy
Definition
use of an endoscopy for evaluation of GI disorders, patient education
Term
ultrasonography
computed tomography (CT) or computed axial tomography (CAT)
magnetic resonance imaging (MRI)
endoscopy
Definition
examples of imaging studies to evaluate the GI tract
Term
plain x-ray
x-ray with contrast
upper GI series
lower GI series
Definition
examples of radiology used to study the GI tract
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