Term
What age group is most likely to get chronic Hep b?
What is the treatment? |
|
Definition
Kids
IFN alpha and Anti-virals |
|
|
Term
| What are the manifestations of Hep D |
|
Definition
Coinfection: Fulminant Hepatitis
Superinfection: Chronic cirrhosis disease |
|
|
Term
| What is the leading cause of liver transplant? |
|
Definition
|
|
Term
What is the predominant mode of HepC transmission?
How is it treated?
How long does it take a chronic infection to cause hepatocelluar carcinoma? |
|
Definition
IV drug use
Pegylated IFN alpha w Ribavirin
Carcinoma: 30 years |
|
|
Term
| How is Alcoholic Hepatitis treated |
|
Definition
|
|
Term
What is NASH or NAFL associated with?
How is it diagnosed? |
|
Definition
The metabolic syndrome
DM, Hyperlipidemia, Obesity
Dx: Exclusion
|
|
|
Term
What are the lab tests for Autoimmune Liver Disease?
How is it treated?
What sex and age is affected? |
|
Definition
ALT, AST elevation
ANA, Anti-SM antiboidies
Elevated IgG
Tx: Corticosteroids
Sex and Age: 15-40 yr old Women
|
|
|
Term
What are the major presenting signs of PBC?
What are the lab results of Primary Biliary Cirrhosis?
What would biopsy show
Who does it commonly affect?
How is it Treated? |
|
Definition
Signs: Fatigue and Pruritis
Labs:
ALP
Anti-mitochondria Antibody
Biopsy:
Florid duct lesions
Proliferative Cholangitis
Portal Tract Granulomas
Who: Middle aged women
Treatment: Ursodeoxycholic Acid |
|
|
Term
What disease is Primary Scelrosing cholangitis associated with?
How is the Diagnosis made?
What is the most severe risk? |
|
Definition
UC
Dx: MRCP, ERCP
Risk: Cholangiocarcinoma |
|
|
Term
What is the pathogenesis of Hereditary Hemochromatosis?
When does it present?
What are some complications?
What is the treatment?
What complications are not relieved by the treatment?
What do the iron labs show? |
|
Definition
HFE mutation on Chromosome 6 increases Fe absorption
Present: 50-60's
Complications
Skin Bronzing
Dialated Cardiomyopathy
Hepatocellular Carcinoma
Diabetes Mellitis
Chondrocalcinosis
Unusual Infections
Treatment: Phlebotomy doesn't relief hpogonadism or chondrocalcinosis
Iron: Low Total binding capacity, high saturation of transferrin and high ferritin |
|
|
Term
What form of Alpha 1 Anti-trypsin deficiency causes cirrhosis?
What form of Alpha 1 Anti-trypsin deficiency causes emphysema?
How does it appear on biopsy? |
|
Definition
Cirrhosis: PiZZ
Emphysema: PiSZ, PiSS
PAS(+) intracellular inclusions |
|
|
Term
What are the complications of Wilson's disease?
How is it Diagnosed and treated? |
|
Definition
K-F Lesions in Descemet's Membrane
Fanconi Syndrome
Hepatitic Injury
Psychosis
Dx:
Serum Ceruloplasm
24 hr Copper
K-F slit lamp
Confirmation with biopsy
Tx
Penacillamine
Trientine
Zinc |
|
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